{"title":"Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rat: A Novel Model of Obese Type 2 Diabetes","authors":"S. Fukuda, K. Miyajima, T. Sasase, T. Ohta","doi":"10.2174/1876524601104010030","DOIUrl":null,"url":null,"abstract":"Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments. Spontaneously Diabetic Torii Lepr fa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. We have investigated the characteristics of SDT fatty rats. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications in SDT fatty rats were seen at younger ages than those in the SDT rats. Furthermore, we evaluated the pharmacological effects of anti-diabetic drugs, such as metformin, pioglitazone, and dipeptidyl peptidase-4 inhibitor on SDT fatty rats. SDT fatty rat is a useful model for analysis of metabolic disease and the evaluation of drugs related to metabolic disease.","PeriodicalId":22762,"journal":{"name":"The Open Diabetes Journal","volume":"36 1","pages":"30-36"},"PeriodicalIF":0.0000,"publicationDate":"2011-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Diabetes Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876524601104010030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments. Spontaneously Diabetic Torii Lepr fa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. We have investigated the characteristics of SDT fatty rats. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications in SDT fatty rats were seen at younger ages than those in the SDT rats. Furthermore, we evaluated the pharmacological effects of anti-diabetic drugs, such as metformin, pioglitazone, and dipeptidyl peptidase-4 inhibitor on SDT fatty rats. SDT fatty rat is a useful model for analysis of metabolic disease and the evaluation of drugs related to metabolic disease.
糖尿病动物模型在阐明糖尿病及其并发症的发病机制、开发新型治疗药物等方面具有重要作用。将Zucker脂肪大鼠的fa等位基因导入SDT大鼠基因组，建立了自发性糖尿病Torii Lepr fa (SDT fatty)大鼠，是肥胖型2型糖尿病的新模型。我们研究了SDT脂肪大鼠的特征。与SDT大鼠相比，雄性和雌性SDT脂肪大鼠均表现出明显的肥胖，并且在年轻时观察到高血糖和高脂血症。肥胖大鼠糖尿病发病早，糖尿病并发症出现的年龄比肥胖大鼠小。此外，我们评估了抗糖尿病药物，如二甲双胍、吡格列酮和二肽基肽酶-4抑制剂对SDT脂肪大鼠的药理作用。SDT脂肪大鼠是分析代谢性疾病和评价代谢性疾病相关药物的有用模型。
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