COMPARISON OF ORAL PREMEDICATION IN CHILDREN (1-16YRS) USING MIDAZOLAM VERSUS CLONIDINE: A PROSPECTIVE DOUBLE BLIND STUDY

Abstract

Background Premedication in pediatric anesthesia is a challenge for Anesthesiologist. Anxious children have higher incidence of negative postoperative behaviors for up to two weeks after surgery. Hence, right premedication is the eternal search for anesthesia fraternity. Aims and Objectives To compare oral midazolam (0.5mg/kg) with oral clonidine (4 micrograms/kg) as a pre medication in children Material & Methods This study was carried out on 30 children who were admitted to Yenepoya Medical College & Hospital for surgical intervention under general anaesthesia during the period from 01-10-2009 to 30-11-2011. Result In the midazolam group the sedation score after 30 mins and 90 mins, 80% of the subjects were awake . In the Clonidine group it was found that 66.7% are drowsy at 30 mins and 70% are drowsy at 90 mins. The difference between to the groups was statistically highly significant. In the midazolam group parental separation were good only in 56% of the subjects where as it was 93.3% in the Clonidine group which is statistically highly significant. In the midazolam group the mask acceptance was good in 86.7% of the subjects . In the Clonidine group 100% of the subjects had good acceptance.   Conclusion Present study showed that premedication oral clonidine appeared to superior than oral midazolam.Oral clonidine produces significantly better sedation than oral midazolam