Pradeep D. Nile, Aditya A. Kulkarni, Ashok A.Shinde, Archana N. Panche, Sanjay N. Harke
{"title":"Extraction, purification and anti-cancer activity of curcumin","authors":"Pradeep D. Nile, Aditya A. Kulkarni, Ashok A.Shinde, Archana N. Panche, Sanjay N. Harke","doi":"10.53022/oarjms.2022.4.1.0072","DOIUrl":null,"url":null,"abstract":"Turmeric has long been used as a strong anti-inflammatory in Indian drug systems. Turmeric is rich in curcuminoids that have different chemical, physico-chemical properties. Current work reports exraction of curcuminoids, curcumin using the Soxhlet extractor. Purification and quantification of curcumin is performed by chromatography. The yield percentage of curcumin reported 4.09% by the Soxhlet extraction method. Different solvent were used for extraction, among them acetone extract was with high yield of curcumin. Individual curcumin extract analysed using UV-VIS Spectroscopy and HPLC. Our results showed that the Salem turmeric contains highest percentage of curcumin. The in vitroMTT assay on the U87MG glioma cell line demanstrated anti-cancer activity of isolated curcumin.","PeriodicalId":19492,"journal":{"name":"Open Access Research Journal of Multidisciplinary Studies","volume":"474 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Access Research Journal of Multidisciplinary Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53022/oarjms.2022.4.1.0072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Turmeric has long been used as a strong anti-inflammatory in Indian drug systems. Turmeric is rich in curcuminoids that have different chemical, physico-chemical properties. Current work reports exraction of curcuminoids, curcumin using the Soxhlet extractor. Purification and quantification of curcumin is performed by chromatography. The yield percentage of curcumin reported 4.09% by the Soxhlet extraction method. Different solvent were used for extraction, among them acetone extract was with high yield of curcumin. Individual curcumin extract analysed using UV-VIS Spectroscopy and HPLC. Our results showed that the Salem turmeric contains highest percentage of curcumin. The in vitroMTT assay on the U87MG glioma cell line demanstrated anti-cancer activity of isolated curcumin.
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