Dental and oral manifestations of coeliac disease - a literature review

Eliza Jakubowska, Patrycja Łazicka, Magdalena Tuczyńska, A. Karolak, Joanna Jasińska
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Abstract

Introduction  Coeliac disease is a genetic autoimmune disease of the digestive system. It is caused by permanent intolerance to gluten (a protein contained in wheat, rye, barley), which results in the atrophy of the intestinal villi in the small intestine and deficiency of nutrients in the body. It can also manifest itself with various pathologies within the teeth and oral mucosa.  Aim of the study  The purpose of the study is to present the symptoms of coeliac disease in oral cavity.  Materials and methods PubMed and Google Scholar medical databases were analyzed, operating with the following keywords: coeliac disease, oral cavity, manifestations, lesions, symptoms, oral health in as many configurations as needed. Twenty-eight related articles published during the last five years (2018-2023) were selected.  Results  In addition to the classic intestinal symptomatology, coeliac disease can also manifest itself in the oral cavity in the form of delayed tooth eruption, enamel defects, MIH, recurrent aphthous stomatitis or xerostomia. The etiology of the changes is still not clear, but studies show that they most likely arise as a result of impaired absorption of vitamins and minerals in the small intestine.  Conclusion The variety of symptoms of celiac disease makes it a significant diagnostic challenge. It is important to raise awareness among dentists about the symptoms of the disease because a quick diagnosis can prevent many complications.    
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乳糜泻的口腔和口腔表现-文献综述
乳糜泻是一种消化系统的遗传性自身免疫性疾病。它是由对麸质(小麦、黑麦、大麦中含有的一种蛋白质)的永久不耐受引起的,这会导致小肠内肠绒毛萎缩和体内营养缺乏。它也可以表现为牙齿和口腔粘膜的各种病理。研究目的本研究的目的是介绍口腔乳糜泻的症状。材料和方法对PubMed和谷歌Scholar医学数据库进行分析,根据需要对以下关键词进行操作:乳糜泻,口腔,表现,病变,症状,口腔健康。选取了近5年(2018-2023年)发表的28篇相关文章。结果乳糜泻除典型的肠道症状外,还可在口腔表现为牙延迟出牙、牙釉质缺损、MIH、复发性口疮性口炎或口干。这些变化的病因尚不清楚,但研究表明,它们很可能是由于小肠对维生素和矿物质的吸收受损而引起的。结论乳糜泻症状的多样性使其诊断面临重大挑战。提高牙医对这种疾病症状的认识是很重要的,因为快速诊断可以预防许多并发症。
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