Cancer hallmarks through the network lens

Abstract

Given the role and relevance of the heterogeneity hallmark in cancer, a current need is to advance the knowledge of the network dynamics building the complex architecture underlying the relationships between cell sub-populations. This step would shed light over obscure mechanisms such as acquired resistance to drugs, for instance. Network medicine has established itself as a systems integrative approach that leverages on the interpretation offered by community-like behavior of bio-entities and clinical variables. Translated over cell sub-population cells, there is a strong case for deciphering cooperative versus antagonist network dynamics in order to determine better therapeutic strategies.