{"title":"A case of clinically aggressive EBV-negative ENKTL in a non-Asian female patient.","authors":"Thomas Kent, Gregory Scott, Robert Seifert","doi":"10.1007/s12308-023-00529-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The patient was a 65-year-old White woman who presented to dermatology with a painless, rapidly growing exophytic nodule on her left upper cheek.</p><p><strong>Aims/purpose: </strong>In this case report, we aim to demonstrate the difficulty of diagnosing Epstein-Barr virus-negative extranodal NK cell lymphomas given the broad differential of NK cell lymphomas and the rarity of EBV-negative extranodal NK cell lymphoma.</p><p><strong>Methods: </strong>Immunohistochemical studies confirmed the diagnosis of cutaneous, extranodal NK cell lymphoma. Interestingly, Epstein-Barr virus in situ hybridization was negative, which is unusual for most NK cell lymphomas.</p><p><strong>Results/conclusions: </strong>In our view, a combination of immunohistochemistry, clonality assessment, sequencing, and flow cytometric studies is required.</p>","PeriodicalId":23182,"journal":{"name":"Thin Solid Films","volume":"517 1","pages":"33-38"},"PeriodicalIF":2.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thin Solid Films","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s12308-023-00529-8","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MATERIALS SCIENCE, COATINGS & FILMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The patient was a 65-year-old White woman who presented to dermatology with a painless, rapidly growing exophytic nodule on her left upper cheek.
Aims/purpose: In this case report, we aim to demonstrate the difficulty of diagnosing Epstein-Barr virus-negative extranodal NK cell lymphomas given the broad differential of NK cell lymphomas and the rarity of EBV-negative extranodal NK cell lymphoma.
Methods: Immunohistochemical studies confirmed the diagnosis of cutaneous, extranodal NK cell lymphoma. Interestingly, Epstein-Barr virus in situ hybridization was negative, which is unusual for most NK cell lymphomas.
Results/conclusions: In our view, a combination of immunohistochemistry, clonality assessment, sequencing, and flow cytometric studies is required.
期刊介绍：
Thin Solid Films is an international journal which serves scientists and engineers working in the fields of thin-film synthesis, characterization, and applications. The field of thin films, which can be defined as the confluence of materials science, surface science, and applied physics, has become an identifiable unified discipline of scientific endeavor.
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