{"title":"Molecular mechanisms of action of anticancer agents involving free radical intermediates","authors":"J. William Lown","doi":"10.1016/8755-9668(85)90009-2","DOIUrl":null,"url":null,"abstract":"<div><p>An extensive discussion is presented of the mechanisms of action of clinically useful anticancer agents in which free radical intermediates have been implicated in their cytotoxic action and/or metabolism. In addition the several factors contributing to drug metabolism and activation and interaction with macromolecular cell targets are discussed as they relate to free radical pathways. Consideration is also given to the action and levels in different tissues of cell protective enzymes against oxidative lesions and the clinicnal implication to anticancer drug action and toxicity.</p></div>","PeriodicalId":100046,"journal":{"name":"Advances in Free Radical Biology & Medicine","volume":"1 2","pages":"Pages 225-264"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/8755-9668(85)90009-2","citationCount":"59","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Free Radical Biology & Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/8755966885900092","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 59
Abstract
An extensive discussion is presented of the mechanisms of action of clinically useful anticancer agents in which free radical intermediates have been implicated in their cytotoxic action and/or metabolism. In addition the several factors contributing to drug metabolism and activation and interaction with macromolecular cell targets are discussed as they relate to free radical pathways. Consideration is also given to the action and levels in different tissues of cell protective enzymes against oxidative lesions and the clinicnal implication to anticancer drug action and toxicity.
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