Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model

Abstract

Background : Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D. Objectives : The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model. Materials and method : the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile. Results : isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D. Conclusion : vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D.