Clinical and Metabolic Studies of a Low‐estrogen Dose Combined Oral Contraceptive in Thai Women

Abstract

Administration of a low-estrogen combined oral contraceptive containing 0.15 mg d-norgestrel and 30 μg ethinyl estradiol per tablet to 268 Thai women for clinical study and in another group of 13 Thai women for metabolic study provided a satisfactory result. No effect of the treatment was observed on blood pressure, serum triglycerides, total serum cholesterol or liver function. However, minor changes in the body weight, oral glucose tolerance and serum insulin were observed. This oral contraceptive preparation seemed to gain the body weight and to show its acceptability and effectiveness, but a firm conclusion could not be drawn on either of them which was due to a high loss to follow-up in the study.