Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00525.X
P. Ouyang, Su‐cheng Huang, F. Hsieh, Ann‐Jan Pang, H. Wen, P. Wei
AFP in 262 patients with genital malignancy, 28 with non-genital malignancy, 58 with benign ovarian tumors, 56 with hydatidiform mole, 12 with choriocarcinoma and 83 healthy females was determined by AFP radioimmunoassay. It was found in 1 patient with corpus cancer, 5 with ovarian malignancy, 4 with testicular malignancy and 2 with partial hydatidiform mole. The importance of immunocytochemical localization of tumor markers is emphasized and the concept of apparent half-life (AHL) of AFP is introduced.
{"title":"Alpha-fetoprotein (AFP) in Gynecological Tumors","authors":"P. Ouyang, Su‐cheng Huang, F. Hsieh, Ann‐Jan Pang, H. Wen, P. Wei","doi":"10.1111/J.1447-0756.1981.TB00525.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00525.X","url":null,"abstract":"AFP in 262 patients with genital malignancy, 28 with non-genital malignancy, 58 with benign ovarian tumors, 56 with hydatidiform mole, 12 with choriocarcinoma and 83 healthy females was determined by AFP radioimmunoassay. It was found in 1 patient with corpus cancer, 5 with ovarian malignancy, 4 with testicular malignancy and 2 with partial hydatidiform mole. \u0000 \u0000 \u0000 \u0000The importance of immunocytochemical localization of tumor markers is emphasized and the concept of apparent half-life (AHL) of AFP is introduced.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"15 1","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75299130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1984.TB00725.X
J. Correy
A very successful meeting of the Education Committee together with executive members of AOFOG was held in Seoul, Korea at the time of the IX AOFOG Congress. Representatives were present from Australia, Sri Lanka, Japan, Korea, Thailand, Republic of China, Indonesia, India, Singapore, New Zealand, Malaysia, Philippines, Hong Kong, and Pakistan.
{"title":"Report of the Education Committee 1983–1984","authors":"J. Correy","doi":"10.1111/J.1447-0756.1984.TB00725.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1984.TB00725.X","url":null,"abstract":"A very successful meeting of the Education Committee together with executive members of AOFOG was held in Seoul, Korea at the time of the IX AOFOG Congress. Representatives were present from Australia, Sri Lanka, Japan, Korea, Thailand, Republic of China, Indonesia, India, Singapore, New Zealand, Malaysia, Philippines, Hong Kong, and Pakistan.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"2 1","pages":"565-567"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81347141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1992.TB00308.X
J. Rizvi, Rasul Saadia, Malik Shamim, Rehamatuallh Amin, Khan M. Ata
In order to determine the prevalence of glucose intolerance in pregnancy, 2,230 consecutive women attending the antenatal clinic at the Aga Khan University Medical Centre in Karachi, Pakistan were subjected on the first antenatal visit, irrespective of gestational age, to a 75 g glucose challenge followed 2 hr later by plasma glucose determination. The test, was repeated at 28-32 weeks of gestation for those patients who had an abnormal initial screen at less than 28 weeks gestation followed by a normal glucose tolerance test and for those who had a risk factor for gestational diabetes even though the initial screen at less than 28 weeks gestation was normal. The initial glucose challenge test was abnormal (2 hr plasma glucose greater than 140 mg%) in 8.6% of the screened population. An oral glucose tolerance test on these patients revealed a prevalence for the entire population of 3.5% of gestational diabetes and 1.9% of impaired glucose tolerance test based on the modified O'Sullivan criteria. Patients with abnormal glucose tolerance test were older, had higher parity, a past history of macrosomia and a family history of diabetes compared to the controls. These patients also had a higher incidence of preterm labour and caesarean section. In the neonates hypoglycemia and hyperbilirubinemia were similarly higher. The fetal abnormality rate was 5.6% and the perinatal mortality was 28/1,000 which were higher than the controls.
{"title":"Experience with screening for abnormal glucose tolerance in pregnancy: maternal and perinatal outcome.","authors":"J. Rizvi, Rasul Saadia, Malik Shamim, Rehamatuallh Amin, Khan M. Ata","doi":"10.1111/J.1447-0756.1992.TB00308.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1992.TB00308.X","url":null,"abstract":"In order to determine the prevalence of glucose intolerance in pregnancy, 2,230 consecutive women attending the antenatal clinic at the Aga Khan University Medical Centre in Karachi, Pakistan were subjected on the first antenatal visit, irrespective of gestational age, to a 75 g glucose challenge followed 2 hr later by plasma glucose determination. The test, was repeated at 28-32 weeks of gestation for those patients who had an abnormal initial screen at less than 28 weeks gestation followed by a normal glucose tolerance test and for those who had a risk factor for gestational diabetes even though the initial screen at less than 28 weeks gestation was normal. The initial glucose challenge test was abnormal (2 hr plasma glucose greater than 140 mg%) in 8.6% of the screened population. An oral glucose tolerance test on these patients revealed a prevalence for the entire population of 3.5% of gestational diabetes and 1.9% of impaired glucose tolerance test based on the modified O'Sullivan criteria. Patients with abnormal glucose tolerance test were older, had higher parity, a past history of macrosomia and a family history of diabetes compared to the controls. These patients also had a higher incidence of preterm labour and caesarean section. In the neonates hypoglycemia and hyperbilirubinemia were similarly higher. The fetal abnormality rate was 5.6% and the perinatal mortality was 28/1,000 which were higher than the controls.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"6 1","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73985791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1985.TB00758.X
I. Fuchi, K. Noda
Summary For this stud-, Preglandin (16, 16 dimeth-l trans-Δ2-PGE1 meth-l ester) was used for midtrimester artificial abortion. The methodolog-, however, differed from that described in other reports. Our present method includes first inserting laminaria tents to dilate the cervix and administering albumin tannate to prevent side effects. We then insert PGEj vaginal suppositories to induce artificial abortion and use epidural anesthesia to relieve pain. A total of 19 patients were used for this stud-. In 15 patients, the abortion was performable before 5 or less PGE1 vaginal suppositories had been used. The remaining 4 patients did not reach this stage until after intravenous drip PGF2α had been administered the following da-. PGE1 is simple to use and appears to be effective in midtrimester artificial abortion if attention is given to the possibilit- of bag rupture, which ma- occur during the earl- stage of the treatment.
{"title":"Midtrimester artificial abortion using 16, 16-dimethyl-trans-delta 2-PGE1 methyl ester (Preglandin), laminaria tents and continuous epidural anesthesia.","authors":"I. Fuchi, K. Noda","doi":"10.1111/J.1447-0756.1985.TB00758.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1985.TB00758.X","url":null,"abstract":"Summary \u0000 \u0000For this stud-, Preglandin (16, 16 dimeth-l trans-Δ2-PGE1 meth-l ester) was used for midtrimester artificial abortion. The methodolog-, however, differed from that described in other reports. Our present method includes first inserting laminaria tents to dilate the cervix and administering albumin tannate to prevent side effects. We then insert PGEj vaginal suppositories to induce artificial abortion and use epidural anesthesia to relieve pain. \u0000 \u0000 \u0000 \u0000A total of 19 patients were used for this stud-. In 15 patients, the abortion was performable before 5 or less PGE1 vaginal suppositories had been used. The remaining 4 patients did not reach this stage until after intravenous drip PGF2α had been administered the following da-. PGE1 is simple to use and appears to be effective in midtrimester artificial abortion if attention is given to the possibilit- of bag rupture, which ma- occur during the earl- stage of the treatment.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"5 1","pages":"377-85"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77561550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1989.TB00148.X
Luan Ji-qing
This study is a result of treatment obtained from 106 patients who had eclampsia over a 15-year period from January 1973 to December 1987. All patients were treated for eclampsia by delivering infants as early as possible, either transvaginally or by cesarean section. By use of this method, as opposed to the administration of magnesium sulfate, the outcome for both mothers and newborns was acceptable. Of the 106 cases, cesarean sections were performed on 59 cases with antenatal eclampsia. There was no maternal death, while the perinatal mortality rate of infants was 2.78%. This study is a profile of cases where early delivery was chosen as a means of treatment for eclampsia.
{"title":"The treatment of eclampsia by early interruption of pregnancy: a 15-year review.","authors":"Luan Ji-qing","doi":"10.1111/J.1447-0756.1989.TB00148.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1989.TB00148.X","url":null,"abstract":"This study is a result of treatment obtained from 106 patients who had eclampsia over a 15-year period from January 1973 to December 1987. All patients were treated for eclampsia by delivering infants as early as possible, either transvaginally or by cesarean section. By use of this method, as opposed to the administration of magnesium sulfate, the outcome for both mothers and newborns was acceptable. Of the 106 cases, cesarean sections were performed on 59 cases with antenatal eclampsia. There was no maternal death, while the perinatal mortality rate of infants was 2.78%. This study is a profile of cases where early delivery was chosen as a means of treatment for eclampsia.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"46 1","pages":"33-35"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85974682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1984.TB00037.X
K. Kawagoe, S. Mori
Tissue distribution of the subunits of human chorionic gonadotropin (hCG), hCGα and hCGβ, in eight cases of trophoblastic tumors, including four cases of choriocarcinoma, two cases of invasive mole and two cases of hydatidiform mole, was studied by the immunoperoxidase method. In villous trophoblasts of hydatidiform mole, though distribution patterns in the cytoplasm differed, both hCGα and hCGβ were revealed to be located chiefly in the syncytiotrophoblast and to a lesser extent in the cytotrophoblast suggesting that hCG is not only localized but also synthesized mainly in the syncytiotrophoblast while the immature cytotrophoblast does not produce hCG. In invasive mole, villi were markedly degenerative, composed mostly of the syncytiotrophoblast with scarce intraplasmic hCGα. This condition of the villi is considered to be the result of intensive chemotherapy prior to operation, and may be explained by the so-called cellular effect of transient increase of hCG in the serum during chemotherapy. In choriocarcinoma, strongly immunoreactive products of hCGα and hCGβ were observed in the syncytiotrophoblast-like cells with several nuclei scattered like islands in the invading front. These findings are considered to be related to the local immunosuppressive effect of hCG on invasion and survival of choriocarcinoma cells analogous to the syncytiotrophoblast in the trophoblastic shell and column of normal pregnancy.
{"title":"Localization OF HCGα and HCGβ in Trophoblastic Tumors","authors":"K. Kawagoe, S. Mori","doi":"10.1111/J.1447-0756.1984.TB00037.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1984.TB00037.X","url":null,"abstract":"Tissue distribution of the subunits of human chorionic gonadotropin (hCG), hCGα and hCGβ, in eight cases of trophoblastic tumors, including four cases of choriocarcinoma, two cases of invasive mole and two cases of hydatidiform mole, was studied by the immunoperoxidase method. In villous trophoblasts of hydatidiform mole, though distribution patterns in the cytoplasm differed, both hCGα and hCGβ were revealed to be located chiefly in the syncytiotrophoblast and to a lesser extent in the cytotrophoblast suggesting that hCG is not only localized but also synthesized mainly in the syncytiotrophoblast while the immature cytotrophoblast does not produce hCG. In invasive mole, villi were markedly degenerative, composed mostly of the syncytiotrophoblast with scarce intraplasmic hCGα. This condition of the villi is considered to be the result of intensive chemotherapy prior to operation, and may be explained by the so-called cellular effect of transient increase of hCG in the serum during chemotherapy. In choriocarcinoma, strongly immunoreactive products of hCGα and hCGβ were observed in the syncytiotrophoblast-like cells with several nuclei scattered like islands in the invading front. These findings are considered to be related to the local immunosuppressive effect of hCG on invasion and survival of choriocarcinoma cells analogous to the syncytiotrophoblast in the trophoblastic shell and column of normal pregnancy.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"75 1","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86048818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00539.X
M. Deguchi, M. Mochizuki, S. Tojo
The binding of 125I-labeled hCS was examined in cell membrane fraction obtained from rat liver and mammary gland. The specific binding of 125I-labeled hCS was determined in pregnant rat liver (binding capacity: 1.4 times 10-12 mol/mg protein), nonpregnant liver (0.4 times 10-12) and lactating mammary gland on the 7th post-partum day (0.06 times 10-12). These bindings were displaced from liver or mammary gland by hormones capable of stimulating lactation (i.e., prolactins and human growth hormone). “Lactogenic activity” was investigated in pregnant rat serum by heterologous radioreceptor assay using 125I-labeled hCS and cell membranes of the rat liver. Two peaks of “lactogenic activity” were seen in rat serum throughout pregnancy. The first peak (1321 + 503 ng hCS equivalents/ml) was at mid-pregnancy and the second peak (1232 + 819 ng) was near term. It appears that this activity in serum is mainly due to a placental lactogenic hormone in rats.
125i标记的hCS在大鼠肝脏和乳腺细胞膜上的结合情况。测定125i标记hCS在妊娠大鼠肝脏(1.4倍10-12 mol/mg蛋白)、非妊娠大鼠肝脏(0.4倍10-12)和产后第7天泌乳乳腺(0.06倍10-12)的特异性结合。这些结合被能够刺激泌乳的激素(即催乳素和人类生长激素)从肝脏或乳腺中取代。利用125i标记的hCS和大鼠肝细胞膜，采用异源放射受体法研究妊娠大鼠血清的“致乳活性”。在整个妊娠期间，大鼠血清中出现了两个“产乳活性”高峰。第一个峰(1321 + 503 ng hCS当量/ml)出现在妊娠中期，第二个峰(1232 + 819 ng)出现在妊娠中期。大鼠血清中的这种活性似乎主要是由于一种胎盘产乳激素。
{"title":"Specific Binding of Human Chorionic Somatomammotropin in Rat Liver and Mammary Gland","authors":"M. Deguchi, M. Mochizuki, S. Tojo","doi":"10.1111/J.1447-0756.1981.TB00539.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00539.X","url":null,"abstract":"The binding of 125I-labeled hCS was examined in cell membrane fraction obtained from rat liver and mammary gland. The specific binding of 125I-labeled hCS was determined in pregnant rat liver (binding capacity: 1.4 times 10-12 mol/mg protein), nonpregnant liver (0.4 times 10-12) and lactating mammary gland on the 7th post-partum day (0.06 times 10-12). These bindings were displaced from liver or mammary gland by hormones capable of stimulating lactation (i.e., prolactins and human growth hormone). “Lactogenic activity” was investigated in pregnant rat serum by heterologous radioreceptor assay using 125I-labeled hCS and cell membranes of the rat liver. Two peaks of “lactogenic activity” were seen in rat serum throughout pregnancy. The first peak (1321 + 503 ng hCS equivalents/ml) was at mid-pregnancy and the second peak (1232 + 819 ng) was near term. It appears that this activity in serum is mainly due to a placental lactogenic hormone in rats.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"62 1","pages":"331-339"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90355279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00532.X
S. Koike, T. Jimbo, M. Mizuno, S. Sakamoto
In the first half of this study, attempts have been made to establish a new score which was designated Mullerian-Inhibition Score (M.I. Score) in order to represent quantitatively the grades of regression of the Mullerian duct. The Mullerian-Inhibiting activities expressed as M.I. Score were analyzed in the testes of fetal rats and in those of fetal and adult pigs by means of organ culture, in which they were cultured for 3 days in close proximity to the primitive Mullerian duct from female rat fetuses. It was revealed that the fetal testes had significantly high M.I. Score. In the latter half of the study, isolation of Mullerian Inhibitor of fetal pig testes was attempted. They were incubated in Eagle's minimum essential medium. The medium was collected, concentrated using a collodion bag and fractionated on a Sephadex G-200 column. The fractions with molecular weight in the range between 190,000 and 280,000 had specifically high M.I. Score.
{"title":"Studies on Müllerian Inhibitors in Rats and Pigs by Semiquantitative Bioassay","authors":"S. Koike, T. Jimbo, M. Mizuno, S. Sakamoto","doi":"10.1111/J.1447-0756.1981.TB00532.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00532.X","url":null,"abstract":"In the first half of this study, attempts have been made to establish a new score which was designated Mullerian-Inhibition Score (M.I. Score) in order to represent quantitatively the grades of regression of the Mullerian duct. The Mullerian-Inhibiting activities expressed as M.I. Score were analyzed in the testes of fetal rats and in those of fetal and adult pigs by means of organ culture, in which they were cultured for 3 days in close proximity to the primitive Mullerian duct from female rat fetuses. It was revealed that the fetal testes had significantly high M.I. Score. \u0000 \u0000 \u0000 \u0000In the latter half of the study, isolation of Mullerian Inhibitor of fetal pig testes was attempted. They were incubated in Eagle's minimum essential medium. The medium was collected, concentrated using a collodion bag and fractionated on a Sephadex G-200 column. The fractions with molecular weight in the range between 190,000 and 280,000 had specifically high M.I. Score.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"19 1","pages":"259-271"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75565307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00524.X
N. Inaba, N. Satoh, R. Ohkawa, K. Kizawa, S. Sekiya, Junkoh Kudoh, H. Takamizawa
We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.
{"title":"Local and Systemic Changes in the Fibrinolytic System During Gynecological Surgery and the Effect of Foy on these Changes","authors":"N. Inaba, N. Satoh, R. Ohkawa, K. Kizawa, S. Sekiya, Junkoh Kudoh, H. Takamizawa","doi":"10.1111/J.1447-0756.1981.TB00524.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00524.X","url":null,"abstract":"We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"2 1","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80092115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-24DOI: 10.1111/J.1447-0756.1981.TB00528.X
Vimolratana Kraivichian, B. Boonsiri, S. Phaosavasdi, Y. Nitichai, P. Tangkeo
Administration of a low-estrogen combined oral contraceptive containing 0.15 mg d-norgestrel and 30 μg ethinyl estradiol per tablet to 268 Thai women for clinical study and in another group of 13 Thai women for metabolic study provided a satisfactory result. No effect of the treatment was observed on blood pressure, serum triglycerides, total serum cholesterol or liver function. However, minor changes in the body weight, oral glucose tolerance and serum insulin were observed. This oral contraceptive preparation seemed to gain the body weight and to show its acceptability and effectiveness, but a firm conclusion could not be drawn on either of them which was due to a high loss to follow-up in the study.
{"title":"Clinical and Metabolic Studies of a Low‐estrogen Dose Combined Oral Contraceptive in Thai Women","authors":"Vimolratana Kraivichian, B. Boonsiri, S. Phaosavasdi, Y. Nitichai, P. Tangkeo","doi":"10.1111/J.1447-0756.1981.TB00528.X","DOIUrl":"https://doi.org/10.1111/J.1447-0756.1981.TB00528.X","url":null,"abstract":"Administration of a low-estrogen combined oral contraceptive containing 0.15 mg d-norgestrel and 30 μg ethinyl estradiol per tablet to 268 Thai women for clinical study and in another group of 13 Thai women for metabolic study provided a satisfactory result. No effect of the treatment was observed on blood pressure, serum triglycerides, total serum cholesterol or liver function. However, minor changes in the body weight, oral glucose tolerance and serum insulin were observed. This oral contraceptive preparation seemed to gain the body weight and to show its acceptability and effectiveness, but a firm conclusion could not be drawn on either of them which was due to a high loss to follow-up in the study.","PeriodicalId":8557,"journal":{"name":"Asia-Oceania journal of obstetrics and gynaecology","volume":"41 3 1","pages":"231-235"},"PeriodicalIF":0.0,"publicationDate":"2010-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77362632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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