Recent Advances in Vaccine Technology for Viral Infection Management: A Spotlight on Next-Generation Vaccines and Nucleic Acid-Based Platforms

Muhammad Zahid Ali, Yousra Anwar, Adil Abbas, Namrah Zafar, Zainab Khalid, A. Sattar, M. Usman, Arzoo Nazir, Shahi Zeb
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Abstract

Recent advances in vaccine technology and their uses in viral infection management were the focus of the study. Potential nucleic acid-based platforms for vaccine development, including DNA and RNA vaccines, were also investigated. During the COVID-19 pandemic, a lot of attention was paid to RNA-based vaccinations like mRNA vaccines because of their rapid development and scalability. These vaccines were shown to be effective at eliciting protective immune responses and provided the adaptability to include multiple antigenic sites. Preclinical and clinical research of this magnitude is required for the development and assessment of these innovative vaccine methods. Immunogenicity, side effects, and efficacy were all taken into account. The study highlighted the need for more investigation and cooperation between researchers, physicians, and business allies to speed up the process of turning these novel vaccine strategies into successful therapies against different types of viral infections. Our study demonstrated the potential of viral vectors, nanoparticles, and nucleic acid-based platforms in developing vaccine technology, and it contributes important insights into the design and evaluation of innovative vaccine tactics against viral diseases. These results add to the existing body of knowledge and may help direct future antiviral research and development. Keywords: Vaccine development, Viruses, DNA Vaccines, RNA Vaccines, COVID-19 Vaccines
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病毒感染管理疫苗技术的最新进展:下一代疫苗和基于核酸的平台
疫苗技术的最新进展及其在病毒感染管理中的应用是研究的重点。还研究了潜在的基于核酸的疫苗开发平台,包括DNA和RNA疫苗。在2019冠状病毒病大流行期间,mRNA疫苗等基于rna的疫苗因其快速发展和可扩展性而备受关注。这些疫苗被证明能有效地引发保护性免疫反应,并提供了包括多个抗原位点的适应性。开发和评估这些创新的疫苗方法需要进行如此大规模的临床前和临床研究。免疫原性、副作用和疗效都被考虑在内。这项研究强调,需要在研究人员、医生和商业盟友之间进行更多的调查和合作,以加快将这些新型疫苗策略转化为针对不同类型病毒感染的成功疗法的进程。我们的研究证明了病毒载体、纳米颗粒和基于核酸的平台在开发疫苗技术方面的潜力,并为设计和评估针对病毒性疾病的创新疫苗策略提供了重要的见解。这些结果增加了现有的知识体系,并可能有助于指导未来的抗病毒研究和开发。关键词:疫苗研制,病毒,DNA疫苗,RNA疫苗,COVID-19疫苗
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