SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF PYRIMIDO [4,5-d] [1,3,4] THIADIAZOLO[3,2-a]PYRIMIDINEDIONE

Abstract

A simple, most efficient and green procedure has been developed for the synthesis of pyrimido [4,5-d] [1,3,4] thiadiazolo [3,2-a] pyrimidinedione derivatives from one-pot three component condensation reactions of barbituric acid, substituted aromatic aldehydes, and 2-amino 5-(4-chlorophenyl)-1,3,4-thiadiazole using 1-Butyl-3-methyl Imidazolium Chloride [BMIM]Cl as a green catalyst in ethanol-water. The newly synthesized compounds evaluated by their spectral techniques and screened for their Antimicrobial activity.