The Prevalence of Self-injurious Behavior in Patients With Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.

IF 1.6 4区地球科学 Q2 PALEONTOLOGY Geobios Pub Date : 2022-11-11 eCollection Date: 2022-01-01 DOI:10.1093/schizbullopen/sgac069

Eva Amanda Lorentzen, Ole Mors, Jesper Nørgaard Kjær

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Abstract

Background and hypothesis: In patients with schizophrenia spectrum disorder (SSD), the lifetime prevalence of self-harm (SH) and non-suicidal self-injury (NSSI) is currently uncertain. The primary aim of this review was to provide a synthesis of the existing literature concerning the prevalence of SH/NSSI in individuals with SSD, and individuals at clinical high risk of psychosis (CHR-P). Secondary aims were to investigate methods, severity, and functions of self-injurious behavior in these populations.

Study design: Studies quantifying the prevalence of SH/NSSI in individuals with SSD or at CHR-P were included in this review. MEDLINE, EMBASE, and PsycInfo were searched for eligible studies June 10, 2022 and systematically screened by two independent reviewers. Risk of bias was assessed using the Joana Briggs Institute Critical Appraisal Checklist for Prevalence Studies by two independent reviewers. A meta-analysis of the lifetime prevalence of SH/NSSI was conducted using generalized linear mixed model with the logit transformation.

Study results: Thirty-two studies were included in this review (n = 15 440), 4 of which included individuals at CHR-P (n = 397). The meta-analysis showed a pooled lifetime prevalence of SH of 31.0% (95% CI: 22.1%; 41.6%) in individuals with SSD (n = 2822) and 39.7% (95% CI: 17.5%; 70.0%) in individuals at CHR-P (n = 397). These estimates should be interpreted with caution due to substantial heterogeneity. Cutting was the most frequent method of SH/NSSI and SH command hallucinations may be an overlooked cause of self-injurious behavior in these patients.

Conclusions: Self-injurious behavior is a highly prevalent, and possibly overlooked concern, in individuals with SSD and at CHR-P.

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精神分裂症谱系障碍患者自伤行为的发生率：系统回顾与元分析》。

背景与假设：在精神分裂症谱系障碍（SSD）患者中，自残（SH）和非自杀性自伤（NSSI）的终生发生率目前尚不确定。本综述的主要目的是对现有文献中有关精神分裂症谱系障碍（SSD）患者和临床高危精神病患者（CHR-P）的自伤/非自杀性自伤发生率进行综述。次要目的是调查这些人群中自伤行为的方法、严重程度和功能：本综述纳入了对 SSD 患者或临床高危精神病患者中 SH/NSSI 发生率进行量化的研究。2022年6月10日，我们在MEDLINE、EMBASE和PsycInfo上检索了符合条件的研究，并由两位独立审稿人进行了系统筛选。两位独立审稿人使用 Joana Briggs Institute 流行病学研究批判性评估清单对偏倚风险进行了评估。采用对数转换的广义线性混合模型对SH/NSSI的终生流行率进行了荟萃分析：本综述共纳入 32 项研究（n = 15 440），其中 4 项研究纳入了 CHR-P 的个体（n = 397）。荟萃分析表明，在 SSD 患者（n = 2822）和 CHR-P 患者（n = 397）中，SH 的汇总终生患病率分别为 31.0% (95% CI: 22.1%; 41.6%)和 39.7% (95% CI: 17.5%; 70.0%)。由于存在很大的异质性，在解释这些估计值时应谨慎。切割是最常见的SH/NSSI方法，SH指令幻觉可能是这些患者自伤行为的一个被忽视的原因：自伤行为在 SSD 患者和 CHR-P 患者中非常普遍，也可能是一个被忽视的问题。

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来源期刊

Geobios 地学-古生物学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Geobios publishes bimonthly in English original peer-reviewed articles of international interest in any area of paleontology, paleobiology, paleoecology, paleobiogeography, (bio)stratigraphy and biogeochemistry. All taxonomic groups are treated, including microfossils, invertebrates, plants, vertebrates and ichnofossils. Geobios welcomes descriptive papers based on original material (e.g. large Systematic Paleontology works), as well as more analytically and/or methodologically oriented papers, provided they offer strong and significant biochronological/biostratigraphical, paleobiogeographical, paleobiological and/or phylogenetic new insights and perspectices. A high priority level is given to synchronic and/or diachronic studies based on multi- or inter-disciplinary approaches mixing various fields of Earth and Life Sciences. Works based on extant data are also considered, provided they offer significant insights into geological-time studies.