{"title":"Improvements in frequency-domain based NIRF optical tomography modality for preclinical studies","authors":"C. Darne, E. Sevick-Muraca","doi":"10.1117/12.2057809","DOIUrl":null,"url":null,"abstract":"Herein we present recent improvements in system design and performance evaluation of near-infrared fluorescence (NIRF) frequency-domain photon migration (FDPM) system developed for small animal fluorescence tomography and installed within a commercial micro-CT/PET scanner. We improved system performance by increasing signal-to-noise ratio (SNR) through use of high powered rf modulation, novel data collection scheme, and data discrimination based on the associated noise levels. Noise characteristics show improvement with these techniques and are currently being employed to improve 3-D fluorescence for tomographic reconstructions in phantoms before incorporating into hybrid scanner.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2014-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational biophotonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2057809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Herein we present recent improvements in system design and performance evaluation of near-infrared fluorescence (NIRF) frequency-domain photon migration (FDPM) system developed for small animal fluorescence tomography and installed within a commercial micro-CT/PET scanner. We improved system performance by increasing signal-to-noise ratio (SNR) through use of high powered rf modulation, novel data collection scheme, and data discrimination based on the associated noise levels. Noise characteristics show improvement with these techniques and are currently being employed to improve 3-D fluorescence for tomographic reconstructions in phantoms before incorporating into hybrid scanner.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
