Assessing the Impact of Age andndash;Vaccination Structure Models on the Dynamics of Tuberculosis Transmission

Abstract

Vaccination has been the only preventive mechanism of tuberculosis (TB) yet due to inconsistencies in the efficacy of the mostly used vaccine, Baccille Calmette-Guerin (BCG), re-vaccination has been deemed to be ineffective. In this work, we sought to assess the impact of age-vaccination and re-vaccination on the transmission dynamics of TB. We developed an age-vaccination re- vaccination model to explore the disease transmission dynamics and the impact of re-vaccination on the disease transmission. By applying the vaccine within ten year intervals, we noticed that, there is no significant difference when the vaccine is administered once or many times for people less than 45 years of age. However, re-vaccination can prove to be effective when it is applied either before or immediately after the waning of the first vaccine.