Evaluation of Antidibetic Potential of Hydromethanolic Extract of Tridax procubens (Linn) in Mice

Abstract

The aqueous leaves extract of Tridax procumbent (Linn) was evaluated for its antidiabetic potential on normal and streptozotocin (STZ)-induced diabetic rats. In the chronic model, the hydromethanolic leaf extract was administered to normal and STZ- induced diabetic rats at the doses of 200 and 400mg/kg body weight (b.w.) p.o. per day for 14 days. The fasting Blood Glucose Levels (BGL), serum insulin level and biochemical data such as glycosylated hemoglobin, Total Cholesterol (TC), Triglycerides (TG), High Density Lipoproteins (HDL) and Low Density Lipoproteins (LDL) were evaluated and all were compared to that of the known anti-diabetic drug glibenclamide. The statistical data indicated significant increase in the body weight, liver glycogen, serum insulin and HDL levels and decrease in blood glucose, glycosylated hemoglobin, total cholesterol and serum triglycerides when compared with glibenclamide. Thus the hydromethanolic leaves extract of Tridax procumben had beneficial effects in reducing the elevated blood glucose level and lipid profile of STZ-induced diabetic rats.