Analysis of factors related to perineural invasion in cervical cancer and its relationship with prognosis

Q4 Medicine 中国医师杂志 Pub Date : 2020-02-29 DOI:10.3760/CMA.J.ISSN.1008-1372.2020.02.006

Chuqi Yang, Li Zheng, Liane Zhou, Anxia Wan, Shijun Wang

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Abstract

Objective To investigate the relationship between perineural invasion (PNI) and the clinicopathological features of cervical cancer, and to explore its influence on the prognosis of cervical cancer patients. Methods Retrospective analysis the clinical data of 76 patients with early cervical cancer who received radical hysterectomy+ pelvic lymphadenectomy±paraaortic lymphadenectomy from November 2015 to December 2019 in Xuanwu Hospital. The clinicopathological characteristics of the postoperative pathological results of cervical cancer patients were analyzed to explore the related factors of PNI and its influence on prognosis. Results Single factor analysis suggested that the incidence of PNI was related to tumor diameter, depth of stroma invasion, lymph-vascular space invasion, lymph node metastasis and clinical stage (P 0.05). Conclusions PNI is related to the depth of interstitial infiltration. PNI has no significant effect on the short-term recurrence rate and short-term survival rate of cervical cancer patients. Key words: Uterine cervical neoplasms; Perineural invasion; Prognosis; Factor analysis, statistical

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宫颈癌神经周围浸润相关因素分析及其与预后的关系

目的探讨宫颈周围神经浸润(PNI)与宫颈癌临床病理特征的关系，并探讨其对宫颈癌患者预后的影响。方法回顾性分析2015年11月至2019年12月宣武医院行根治性子宫切除术+盆腔淋巴结切除术+主动脉旁淋巴结切除术的76例早期宫颈癌患者的临床资料。分析宫颈癌患者术后病理结果的临床病理特点，探讨PNI的相关因素及其对预后的影响。结果单因素分析提示PNI的发生率与肿瘤直径、间质浸润深度、淋巴血管间隙浸润、淋巴结转移及临床分期有关(P < 0.05)。结论PNI与间质浸润深度有关。PNI对宫颈癌患者的短期复发率和短期生存率无显著影响。关键词:子宫颈肿瘤;围神经的入侵;预后;因子分析、统计学

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