Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20190329-00359
Xiaogang Wang, Wei-qiao Zhu
Objective To observe the effect of carotid endarterectomy (CEA) on the patients with ischemic stroke, and to observe the effect on the function of nerve and blood coagulation. Methods The patients who were treated with ischemic stroke in our hospital from February 2017 to December 2017 were selected as the research subjects. According to the treatment methods, the patients were divided into the carotid angioplasty stenting (CAS) group (n=45) and the CEA treatment group (n=45). The therapeutic effects of the two groups were observed, and the differences of coagulation function and quality of life between the two groups before and after treatment were compared. Results The effective rate of treatment in the CEA treatment group was 97.78%, which was significantly higher than that of the CAS group (χ2=4.939, P=0.026). The two groups had no difference in coagulation function before treatment. After the treatment, the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer (D-D) in the CEA group were lower than those in the CAS group (t=22.801, 3.752, 6.039, 169.556, P<0.05). There was no difference in the quality of life between the two groups before treatment. After treatment, the quality of life of the CEA treatment group was higher than that of the CAS group (P<0.05). The incidence of high perfusion syndrome, restenosis and hematoma in group CEA was lower than that in group CAS (χ2=4.406, P=0.036). Conclusions CEA has good therapeutic effect on patients with ischemic stroke. It can obviously improve the nerve function and coagulation function of patients, and has a good application value. Key words: Endarterectomy, carotid; Stroke; Neurological function; Coagulation function
{"title":"Effect of CEA on neurological function and coagulation function in patients with ischemic stroke","authors":"Xiaogang Wang, Wei-qiao Zhu","doi":"10.3760/CMA.J.CN431274-20190329-00359","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190329-00359","url":null,"abstract":"Objective \u0000To observe the effect of carotid endarterectomy (CEA) on the patients with ischemic stroke, and to observe the effect on the function of nerve and blood coagulation. \u0000 \u0000 \u0000Methods \u0000The patients who were treated with ischemic stroke in our hospital from February 2017 to December 2017 were selected as the research subjects. According to the treatment methods, the patients were divided into the carotid angioplasty stenting (CAS) group (n=45) and the CEA treatment group (n=45). The therapeutic effects of the two groups were observed, and the differences of coagulation function and quality of life between the two groups before and after treatment were compared. \u0000 \u0000 \u0000Results \u0000The effective rate of treatment in the CEA treatment group was 97.78%, which was significantly higher than that of the CAS group (χ2=4.939, P=0.026). The two groups had no difference in coagulation function before treatment. After the treatment, the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer (D-D) in the CEA group were lower than those in the CAS group (t=22.801, 3.752, 6.039, 169.556, P<0.05). There was no difference in the quality of life between the two groups before treatment. After treatment, the quality of life of the CEA treatment group was higher than that of the CAS group (P<0.05). The incidence of high perfusion syndrome, restenosis and hematoma in group CEA was lower than that in group CAS (χ2=4.406, P=0.036). \u0000 \u0000 \u0000Conclusions \u0000CEA has good therapeutic effect on patients with ischemic stroke. It can obviously improve the nerve function and coagulation function of patients, and has a good application value. \u0000 \u0000 \u0000Key words: \u0000Endarterectomy, carotid; Stroke; Neurological function; Coagulation function","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75326613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the clinical value of short segment fusion and long segment fusion combined with posterior pedicle screw system internal fixation in the treatment of degenerative scoliosis. Methods 74 patients with degenerative scoliosis who were treated in the Affiliated Hospital of Southwest Medical University from January 2014 to February 2018 were enrolled in the study. The patients were divided into group A and group B with a random number table of 37 cases each. Group A was treated with short segment fusion and posterior pedicle screw system internal fixation, while group B was with long segment fusion and posterior pedicle screw system internal fixation. The Cobb angle of scoliosis, the balance of coronal and sagittal plane of spine were observed before operation, 1 week after operation, 3 months after operation and 6 months after operation, and the incidence of early and long-term complications were counted. Results The Cobb angle of scoliosis in group B was lower than that of group A at 1 week, 3 months and 6 months after operation (P 0.05). There was significant difference in the balance of coronal plane and sagittal plane between the two groups at 6 months after operation (P 0.05). Conclusions Long segment fusion and posterior pedicle screw system internal fixation can improve the Cobb angle and reduce the incidence of postoperative scoliosis, but it is easy to appear the imbalance of coronal and sagittal planes, which can be selected according to the actual situation. Key words: Pedicle screws; Spinal fusion; Degenerative scoliosis
{"title":"The value of posterior pedicle screw rod system internal fixation in the treatment of degenerative scoliosis","authors":"Zhiqiang Liu, Daxiong Feng, Yunlong Zhou, L. Tian, Qingzhong Zhou, Lipeng Zheng","doi":"10.3760/CMA.J.CN431274-20181130-02222","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181130-02222","url":null,"abstract":"Objective \u0000To investigate the clinical value of short segment fusion and long segment fusion combined with posterior pedicle screw system internal fixation in the treatment of degenerative scoliosis. \u0000 \u0000 \u0000Methods \u000074 patients with degenerative scoliosis who were treated in the Affiliated Hospital of Southwest Medical University from January 2014 to February 2018 were enrolled in the study. The patients were divided into group A and group B with a random number table of 37 cases each. Group A was treated with short segment fusion and posterior pedicle screw system internal fixation, while group B was with long segment fusion and posterior pedicle screw system internal fixation. The Cobb angle of scoliosis, the balance of coronal and sagittal plane of spine were observed before operation, 1 week after operation, 3 months after operation and 6 months after operation, and the incidence of early and long-term complications were counted. \u0000 \u0000 \u0000Results \u0000The Cobb angle of scoliosis in group B was lower than that of group A at 1 week, 3 months and 6 months after operation (P 0.05). There was significant difference in the balance of coronal plane and sagittal plane between the two groups at 6 months after operation (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Long segment fusion and posterior pedicle screw system internal fixation can improve the Cobb angle and reduce the incidence of postoperative scoliosis, but it is easy to appear the imbalance of coronal and sagittal planes, which can be selected according to the actual situation. \u0000 \u0000 \u0000Key words: \u0000Pedicle screws; Spinal fusion; Degenerative scoliosis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82446180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20190126-00082
Guodong Zhao, Lingsheng Kong
Non-functioning pituitary adenoma (NFPA), lack of the clinical and biochemical characteristics of hormone overexpression, is a common type of pituitary adenoma. It could bring enormous suffering to the patients on account of the tendentiousness of being invasive macroadenoma and oppressing surrounding tissue. At present, the pathogenesis of NFPA is still unclear, thus there is no effective medical management for the disease. Although transsphenoidal surgery is the first-line treatment for NFPA, it is very difficult to achieve a cure effect. It has been found that the abnormal expression of cyclooxygenase-2 (COX-2) affects the survival and progression of cancer. Recent studies have detected the expression of COX-2 in pituitary tumors, and the expression of COX-2 in NFPA is stronger, suggesting that COX-2 may be involved in the occurrence and development of NFPA. This article reviews the pathogenesis of NFPA and the tumorigenicity of COX-2, and provides new ideas for clinical drug treatment of NFPA. Key words: Cyclooxygenase 2; Non-functioning pituitary adenoma; Pituitary neoplasms; Review
{"title":"Research progress of the pathogenesis of NFPA and the tumorigenicity of COX-2","authors":"Guodong Zhao, Lingsheng Kong","doi":"10.3760/CMA.J.CN431274-20190126-00082","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190126-00082","url":null,"abstract":"Non-functioning pituitary adenoma (NFPA), lack of the clinical and biochemical characteristics of hormone overexpression, is a common type of pituitary adenoma. It could bring enormous suffering to the patients on account of the tendentiousness of being invasive macroadenoma and oppressing surrounding tissue. At present, the pathogenesis of NFPA is still unclear, thus there is no effective medical management for the disease. Although transsphenoidal surgery is the first-line treatment for NFPA, it is very difficult to achieve a cure effect. It has been found that the abnormal expression of cyclooxygenase-2 (COX-2) affects the survival and progression of cancer. Recent studies have detected the expression of COX-2 in pituitary tumors, and the expression of COX-2 in NFPA is stronger, suggesting that COX-2 may be involved in the occurrence and development of NFPA. This article reviews the pathogenesis of NFPA and the tumorigenicity of COX-2, and provides new ideas for clinical drug treatment of NFPA. \u0000 \u0000Key words: \u0000Cyclooxygenase 2; Non-functioning pituitary adenoma; Pituitary neoplasms; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83557411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20190201-00112
Linshuang Zhou, Tingting Shan, Wenpin Cai
Objective To explore the correlation between urinary phthalate concentration and semen quality parameters. Methods A total of 112 males with infertility in our hospital were set as infertility group. Another 65 healthy males who had given birth during the same period in our hospital were selected as control group. The semen samples obtained by urine and masturbation were collected in all the subjects. The semen quality parameters were detected by automatic color sperm quality detection system, and the concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP) and Di 2-Ethyl Hexyl Phthalate (DEHP) in urine were measured by high performance liquid chromatography, and the correlation between concentrations of four phthalates and semen quality parameters was analyzed by spearman correlation coefficient. Results The concentrations of DMP, DEP, DBP, DEHP and total phthalate in infertility group were significantly higher than those in control group (P<0.05). The sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement in infertility group were significantly lower than those in control group (P<0.05), and the ratio of abnormal sperm was significantly higher than that in control group (P<0.05). The concentrations of DMP, DEP, DBP and DEHP in urine were negatively correlated with sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement (P<0.05), and were positively correlated with abnormal sperm ratio (P<0.05). Conclusions The concentration of phthalate is high in urine of infertile males, and its concentration is negatively correlated with semen quality. Phthalate accumulation may be one of the important reasons for male infertility. Key words: Urinalysis; Phthalate; Semen analysis; Infertility, male
{"title":"Correlation between urinary phthalate concentration and semen quality parameters","authors":"Linshuang Zhou, Tingting Shan, Wenpin Cai","doi":"10.3760/CMA.J.CN431274-20190201-00112","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20190201-00112","url":null,"abstract":"Objective \u0000To explore the correlation between urinary phthalate concentration and semen quality parameters. \u0000 \u0000 \u0000Methods \u0000A total of 112 males with infertility in our hospital were set as infertility group. Another 65 healthy males who had given birth during the same period in our hospital were selected as control group. The semen samples obtained by urine and masturbation were collected in all the subjects. The semen quality parameters were detected by automatic color sperm quality detection system, and the concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP) and Di 2-Ethyl Hexyl Phthalate (DEHP) in urine were measured by high performance liquid chromatography, and the correlation between concentrations of four phthalates and semen quality parameters was analyzed by spearman correlation coefficient. \u0000 \u0000 \u0000Results \u0000The concentrations of DMP, DEP, DBP, DEHP and total phthalate in infertility group were significantly higher than those in control group (P<0.05). The sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement in infertility group were significantly lower than those in control group (P<0.05), and the ratio of abnormal sperm was significantly higher than that in control group (P<0.05). The concentrations of DMP, DEP, DBP and DEHP in urine were negatively correlated with sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement (P<0.05), and were positively correlated with abnormal sperm ratio (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The concentration of phthalate is high in urine of infertile males, and its concentration is negatively correlated with semen quality. Phthalate accumulation may be one of the important reasons for male infertility. \u0000 \u0000 \u0000Key words: \u0000Urinalysis; Phthalate; Semen analysis; Infertility, male","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81819854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20181129-02210
ZhaoDong Liu, Jianying Yan, Meimei Guo
Objective The aim of this study is to analyze risk factors and perinatal outcomes of fetal growth restriction (FGR) in the third trimester to improve pregnancy outcomes. Methods The retrospective study collected 676 fetus, included 338 FGR and 338 appropriate for gestational infants. All samples were collected between January 1st 2014 and January 1st 2016 from Fujian Provincial Maternity and Children's Hospital. Multivariate logistic regression analysis was used to analyze the risk factors and pregnancy outcomes of fetal growth restriction between FGR and control group. Results ⑴ Multivariate logistic regression analysis showed that the independent risk factor of FGR was severe preeclampsia for 28-33+ 6 weeks FGR. The independent risk factors of 37-40+ 6 weeks FGR were severe preeclampsia, oligohydramnios, velum attachment of cord and cord around neck. ⑵ Compared with the control group of the same gestational week, the fetal distress rate, 1 minute asphyxia rate of newborn and cesarean section rate of FGR in the 28-33+ 6 gestational week group were all higher than those in the same gestational week group (P<0.05). ⑶ The fetal distress in FGR group was more than in cesarean delivery that in vaginal delivery at 28-33+ 6 weeks of gestation, and that in FGR group was more than that in vaginal delivery at 34-36+ 6 weeks of gestation (P<0.05). Conclusions Severe preeclampsia, oligohydramnios, velum attachment of umbilical cord and cord around the neck are the independent risk factors of FGR in the third trimester. During pregnancy, early intervention such as screening in high risk pregnant women and fetal intrauterine monitoring should be carried out to improve the perinatal outcome. Key words: Pregnancy trimester, third; Fetal growth restriction; Risk factors; Pregnancy outcome
{"title":"Clinical analysis of risk factors and pregancy outcomes of fetal growth restriction in the third trimester","authors":"ZhaoDong Liu, Jianying Yan, Meimei Guo","doi":"10.3760/CMA.J.CN431274-20181129-02210","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181129-02210","url":null,"abstract":"Objective \u0000The aim of this study is to analyze risk factors and perinatal outcomes of fetal growth restriction (FGR) in the third trimester to improve pregnancy outcomes. \u0000 \u0000 \u0000Methods \u0000The retrospective study collected 676 fetus, included 338 FGR and 338 appropriate for gestational infants. All samples were collected between January 1st 2014 and January 1st 2016 from Fujian Provincial Maternity and Children's Hospital. Multivariate logistic regression analysis was used to analyze the risk factors and pregnancy outcomes of fetal growth restriction between FGR and control group. \u0000 \u0000 \u0000Results \u0000⑴ Multivariate logistic regression analysis showed that the independent risk factor of FGR was severe preeclampsia for 28-33+ 6 weeks FGR. The independent risk factors of 37-40+ 6 weeks FGR were severe preeclampsia, oligohydramnios, velum attachment of cord and cord around neck. ⑵ Compared with the control group of the same gestational week, the fetal distress rate, 1 minute asphyxia rate of newborn and cesarean section rate of FGR in the 28-33+ 6 gestational week group were all higher than those in the same gestational week group (P<0.05). ⑶ The fetal distress in FGR group was more than in cesarean delivery that in vaginal delivery at 28-33+ 6 weeks of gestation, and that in FGR group was more than that in vaginal delivery at 34-36+ 6 weeks of gestation (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Severe preeclampsia, oligohydramnios, velum attachment of umbilical cord and cord around the neck are the independent risk factors of FGR in the third trimester. During pregnancy, early intervention such as screening in high risk pregnant women and fetal intrauterine monitoring should be carried out to improve the perinatal outcome. \u0000 \u0000 \u0000Key words: \u0000Pregnancy trimester, third; Fetal growth restriction; Risk factors; Pregnancy outcome","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81521998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20181204-02258
W. Feng, Jin Chen, W. Cui
Objective To explore the effect of minimally invasive percutaneous pedicle screw internal fixation on the anterior height and Cobb angle of injured vertebra in patients with single vertebra magerl type A thoracolumbar fracture. Methods 71 cases of single vertebra magerl type A thoracolumbar fracture admitted in our hospital from January 2015 to January 2017 were reviewed. Among them, 31 patients who received minimally invasive percutaneous pedicle screw internal fixation were as the observation group, and 40 patients receiving open pedicle internal fixation were as control group. All the patients were followed up for one year, and the preoperative and postoperative indexes, the height of the anterior edge of the injured vertebra and Cobb angle, as well as the score of Oswestry dysfunction were compared between the two groups. Results The length of incision and the time of descending were shorter in the observation group than in the control group, and the amount of bleeding during operation was less than in the control group (P 0.05). There was no significant difference in serum creatine kinase (CK) and C-reaction protein (CRP) levels between the two groups (P>0.05); the levels of serum CK and CRP in the two groups increased significantly after operation, and those in the control group were significantly higher than those in the observation group (P 0.05); 7 days and 1 year after operation, the height of the anterior edge of the two groups was significantly higher than that before operation (P 0.05). There was no significant difference in Oswestry dysfunction score between the two groups (P>0.05); the scores of Oswestry dysfunction were significantly reduced in both groups 7 days and 1 year ater operation, and the observation group was significantly lower than the control group (P<0.01). Conclusions Minimally invasive percutaneous pedicle screw fixation can effectively improve the anterior height and Cobb angle of the injured vertebra in patients with single vertebra magerl A thoracolumbar fracture, and the perioperative indexes, serum inflammatory factors and Oswestry dysfunction scores are better than those of open pedicle internal fixation, which is worthy of clinical application. Key words: Pedicle screws; Thoracolumbar fracture; Fracture fixation, internal
{"title":"Minimally invasive percutaneous pedicle screw fixation in the treatment of single vertebra magerl type A thoracolumbar fracture","authors":"W. Feng, Jin Chen, W. Cui","doi":"10.3760/CMA.J.CN431274-20181204-02258","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181204-02258","url":null,"abstract":"Objective \u0000To explore the effect of minimally invasive percutaneous pedicle screw internal fixation on the anterior height and Cobb angle of injured vertebra in patients with single vertebra magerl type A thoracolumbar fracture. \u0000 \u0000 \u0000Methods \u000071 cases of single vertebra magerl type A thoracolumbar fracture admitted in our hospital from January 2015 to January 2017 were reviewed. Among them, 31 patients who received minimally invasive percutaneous pedicle screw internal fixation were as the observation group, and 40 patients receiving open pedicle internal fixation were as control group. All the patients were followed up for one year, and the preoperative and postoperative indexes, the height of the anterior edge of the injured vertebra and Cobb angle, as well as the score of Oswestry dysfunction were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The length of incision and the time of descending were shorter in the observation group than in the control group, and the amount of bleeding during operation was less than in the control group (P 0.05). There was no significant difference in serum creatine kinase (CK) and C-reaction protein (CRP) levels between the two groups (P>0.05); the levels of serum CK and CRP in the two groups increased significantly after operation, and those in the control group were significantly higher than those in the observation group (P 0.05); 7 days and 1 year after operation, the height of the anterior edge of the two groups was significantly higher than that before operation (P 0.05). There was no significant difference in Oswestry dysfunction score between the two groups (P>0.05); the scores of Oswestry dysfunction were significantly reduced in both groups 7 days and 1 year ater operation, and the observation group was significantly lower than the control group (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000Minimally invasive percutaneous pedicle screw fixation can effectively improve the anterior height and Cobb angle of the injured vertebra in patients with single vertebra magerl A thoracolumbar fracture, and the perioperative indexes, serum inflammatory factors and Oswestry dysfunction scores are better than those of open pedicle internal fixation, which is worthy of clinical application. \u0000 \u0000 \u0000Key words: \u0000Pedicle screws; Thoracolumbar fracture; Fracture fixation, internal","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86217676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20200306-00243
Zhiyu Xiao, Chuan-chao He, Jie Wang
Laparoscopy has been used for the treatment of liver tumors for nearly 30 years. Since then, the world's liver surgeon giving a great deal of energy and enthusiasm to this tool, expanding indications and optimizing laparoscopy operation procedures, making indications of laparoscopic liver resection from the edge of liver benign tumors gradually extended to the left lobe, right lobe, left or right anterolateral segmentectomy or posterosuperior segmentectomy, right posterior sectionectomy, central hepatectomy, and extended left/right hepatectomy or caudate lobe. Accompanied by image technology upgrade, energy equipment update and the delicate anatomic stratagem, the security, effectiveness, advantages of laparoscopy in treatment of liver tumor got fully verified recently. There are plenty of basic and clinical research also fully confirmed the perioperative advantage of laparoscopic in liver cancer treatment. For the long-term therapeutic effect, continued case observation and strategy adjustment are still required in future. Key words: Laparoscopy; Hepatectomy; Liver neoplasms
{"title":"Application progress of laparoscopy in the treatment of liver tumors","authors":"Zhiyu Xiao, Chuan-chao He, Jie Wang","doi":"10.3760/CMA.J.CN431274-20200306-00243","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200306-00243","url":null,"abstract":"Laparoscopy has been used for the treatment of liver tumors for nearly 30 years. Since then, the world's liver surgeon giving a great deal of energy and enthusiasm to this tool, expanding indications and optimizing laparoscopy operation procedures, making indications of laparoscopic liver resection from the edge of liver benign tumors gradually extended to the left lobe, right lobe, left or right anterolateral segmentectomy or posterosuperior segmentectomy, right posterior sectionectomy, central hepatectomy, and extended left/right hepatectomy or caudate lobe. Accompanied by image technology upgrade, energy equipment update and the delicate anatomic stratagem, the security, effectiveness, advantages of laparoscopy in treatment of liver tumor got fully verified recently. There are plenty of basic and clinical research also fully confirmed the perioperative advantage of laparoscopic in liver cancer treatment. For the long-term therapeutic effect, continued case observation and strategy adjustment are still required in future. \u0000 \u0000Key words: \u0000Laparoscopy; Hepatectomy; Liver neoplasms","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76520903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20181220-02388
Ying Lin, Qiwen Li, Xiaomei Lin
Objective To analyze the expression levels of miR-15 and miR-29a in serum of patients with diabetic retinopathy (DR) and their diagnostic values for DR. Methods 155 patients (155 eyes) with type 2 diabetes mellitus (DM) were treated in our hospital from June 2016 to August 2018, according to the occurrence of retinopathy and the degree of retinopathy, the patients were divided into five groups: 50 cases of non-retinopathy group (NDR group), 56 cases of simple retinopathy group (SDR group), 49 cases of proliferative retinopathy group (PDR group) and another 50 healthy persons in the same period were selected as the control group. Triglyceride (TG), total cholesterol (TC), and fasting blood glucose (FPG) were measured. Levels of serum miR-15 and miR-29a were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Pearson correlation method was used to analyze the relationships between levels of serum miR-15 and miR-29a with clinical indicators in DR patients. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic values of miR-15 and miR-29a in DR. Results The relative expression of miR-15 in serum of NDR group, SDR group, and PDR group were lower than that of control group (P<0.05), and the relative expression of miR-15 in NDR group, SDR group, and PDR group decreased gradually (P<0.05); the relative expression of miR-29a in serum of NDR group, SDR group, and PDR group were higher than that of control group (P<0.05), and the mRNA relative expression of miR-29a in NDR group, SDR group, and PDR group increased gradually (P<0.05); the expression of serum miR-15 in DR patients was negatively correlated with urinary albumin/creatinine (UACR), glycosylated hemoglobin (HbA1c) and the course of DM (r=-0.732, -0.492, -0.589, P<0.05); the expression level of miR-29a was positively correlated with UACR, HbA1c and the course of DM (r=0.744, 0.508, 0.556, P<0.05); the areas under the ROC curve (AUC) of miR-15 and miR-29a for DR diagnosis were 0.796 (95% CI: 0.724-0.857) and 0.677 (95% CI: 0.597-0.749), with diagnostic thresholds 0.63 and 1.11, sensitivities 84.9% and 53.8%, specificities 65.3% and 79.6%, repectively; miR-29a was a risk factor for DR, while miR-15 was a protective factor for DR. Conclusions The expression of mir-15 and miR-29a in the serum of DR patients is decreased, which is related to the degree of retinopathy and can be used as biomarkers for early diagnosis of DR. Key words: Diabetic retinopathy; miR-15; miR-29a; Early diagnosis
{"title":"Expressions and clinical significances of miR-15 and miR-29a in serum of patients with diabetic retinopathy","authors":"Ying Lin, Qiwen Li, Xiaomei Lin","doi":"10.3760/CMA.J.CN431274-20181220-02388","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181220-02388","url":null,"abstract":"Objective \u0000To analyze the expression levels of miR-15 and miR-29a in serum of patients with diabetic retinopathy (DR) and their diagnostic values for DR. \u0000 \u0000 \u0000Methods \u0000155 patients (155 eyes) with type 2 diabetes mellitus (DM) were treated in our hospital from June 2016 to August 2018, according to the occurrence of retinopathy and the degree of retinopathy, the patients were divided into five groups: 50 cases of non-retinopathy group (NDR group), 56 cases of simple retinopathy group (SDR group), 49 cases of proliferative retinopathy group (PDR group) and another 50 healthy persons in the same period were selected as the control group. Triglyceride (TG), total cholesterol (TC), and fasting blood glucose (FPG) were measured. Levels of serum miR-15 and miR-29a were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Pearson correlation method was used to analyze the relationships between levels of serum miR-15 and miR-29a with clinical indicators in DR patients. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic values of miR-15 and miR-29a in DR. \u0000 \u0000 \u0000Results \u0000The relative expression of miR-15 in serum of NDR group, SDR group, and PDR group were lower than that of control group (P<0.05), and the relative expression of miR-15 in NDR group, SDR group, and PDR group decreased gradually (P<0.05); the relative expression of miR-29a in serum of NDR group, SDR group, and PDR group were higher than that of control group (P<0.05), and the mRNA relative expression of miR-29a in NDR group, SDR group, and PDR group increased gradually (P<0.05); the expression of serum miR-15 in DR patients was negatively correlated with urinary albumin/creatinine (UACR), glycosylated hemoglobin (HbA1c) and the course of DM (r=-0.732, -0.492, -0.589, P<0.05); the expression level of miR-29a was positively correlated with UACR, HbA1c and the course of DM (r=0.744, 0.508, 0.556, P<0.05); the areas under the ROC curve (AUC) of miR-15 and miR-29a for DR diagnosis were 0.796 (95% CI: 0.724-0.857) and 0.677 (95% CI: 0.597-0.749), with diagnostic thresholds 0.63 and 1.11, sensitivities 84.9% and 53.8%, specificities 65.3% and 79.6%, repectively; miR-29a was a risk factor for DR, while miR-15 was a protective factor for DR. \u0000 \u0000 \u0000Conclusions \u0000The expression of mir-15 and miR-29a in the serum of DR patients is decreased, which is related to the degree of retinopathy and can be used as biomarkers for early diagnosis of DR. \u0000 \u0000 \u0000Key words: \u0000Diabetic retinopathy; miR-15; miR-29a; Early diagnosis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85505438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20200306-00241
X. Teng, Hao Bu, Wei-Chang Cheng
Laparoscopic anatomical hepatectomy of hepatic vein approach is a laparoscopic hepatectomy technique based on anatomical hepatectomy and guided by hepatic vein. It not only can completely remove the focus and retain the structural integrity of the remaining liver tissue, but also has the advantages of less trauma and rapid recovery by laparoscopy. When the transection plane is guided by complete exposure of hepatic vein, the ineffective liver tissue without inflow and outflow tract can be completely removed, the possibility of postoperative tumor recurrence and postoperative complications can be reduced, so as to improve the survival rate of patients. At present, it is of great clinical value and widely carried out. This article will review the development of anatomical hepatectomy of hepatic vein approach and the main points of laparoscopic anatomical hepatectomy of hepatic vein approach. Key words: Laparoscopy; Hepatectomy; Hepatic vein approach
{"title":"Laparoscopic anatomical hepatectomy of hepatic vein approach","authors":"X. Teng, Hao Bu, Wei-Chang Cheng","doi":"10.3760/CMA.J.CN431274-20200306-00241","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20200306-00241","url":null,"abstract":"Laparoscopic anatomical hepatectomy of hepatic vein approach is a laparoscopic hepatectomy technique based on anatomical hepatectomy and guided by hepatic vein. It not only can completely remove the focus and retain the structural integrity of the remaining liver tissue, but also has the advantages of less trauma and rapid recovery by laparoscopy. When the transection plane is guided by complete exposure of hepatic vein, the ineffective liver tissue without inflow and outflow tract can be completely removed, the possibility of postoperative tumor recurrence and postoperative complications can be reduced, so as to improve the survival rate of patients. At present, it is of great clinical value and widely carried out. This article will review the development of anatomical hepatectomy of hepatic vein approach and the main points of laparoscopic anatomical hepatectomy of hepatic vein approach. \u0000 \u0000Key words: \u0000Laparoscopy; Hepatectomy; Hepatic vein approach","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84913575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-20DOI: 10.3760/CMA.J.CN431274-20181203-02233
null Cairenzhuoma, Yun Wang
Objective To evaluate the effect of subtotal paravertebral block combined with general anesthesia on the application of open thoracic surgery and its effect on perioperative stress. Methods From January 2016 to January 2018, 70 cases of patients who underwent thoracotomy were studied. According to the simple random method, patients were divided into control group and observation group. The control group was given general anesthesia, and the observation group was given thoracic paravertebral nerve combined with general anesthesia. The changes of hemodynamics, anesthetic effect, anesthesia recovery, stress response and adverse reaction during anesthesia were compared between the two groups. Results There was no significant difference in heart rate (HR), mean arterial pressure (MAP) and blood oxygen saturation (SaO2) between the two groups at 1 min after induction, 1 min intubation and 1 min after extubation (P>0.05). The anesthetic effect of the patients in the observation group was better than that of the control group (P 0.05). Conclusions Ultrasound paravertebral block combined with general anesthesia can improve the anesthesia effect, and has better analgesic effect, less postoperative stress response, and high safety. Key words: Ultrasonography; Paravertebral nerve block; Anesthesia, general; Thoracic surgical procedures
{"title":"Evaluation of the effect of paravertebral block combined with general anesthesia on patients with thoracotomy and its effect on perioperative stress","authors":"null Cairenzhuoma, Yun Wang","doi":"10.3760/CMA.J.CN431274-20181203-02233","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181203-02233","url":null,"abstract":"Objective \u0000To evaluate the effect of subtotal paravertebral block combined with general anesthesia on the application of open thoracic surgery and its effect on perioperative stress. \u0000 \u0000 \u0000Methods \u0000From January 2016 to January 2018, 70 cases of patients who underwent thoracotomy were studied. According to the simple random method, patients were divided into control group and observation group. The control group was given general anesthesia, and the observation group was given thoracic paravertebral nerve combined with general anesthesia. The changes of hemodynamics, anesthetic effect, anesthesia recovery, stress response and adverse reaction during anesthesia were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There was no significant difference in heart rate (HR), mean arterial pressure (MAP) and blood oxygen saturation (SaO2) between the two groups at 1 min after induction, 1 min intubation and 1 min after extubation (P>0.05). The anesthetic effect of the patients in the observation group was better than that of the control group (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Ultrasound paravertebral block combined with general anesthesia can improve the anesthesia effect, and has better analgesic effect, less postoperative stress response, and high safety. \u0000 \u0000 \u0000Key words: \u0000Ultrasonography; Paravertebral nerve block; Anesthesia, general; Thoracic surgical procedures","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86300169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}