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Effect of CEA on neurological function and coagulation function in patients with ischemic stroke CEA对缺血性脑卒中患者神经功能及凝血功能的影响
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20190329-00359
Xiaogang Wang, Wei-qiao Zhu
Objective To observe the effect of carotid endarterectomy (CEA) on the patients with ischemic stroke, and to observe the effect on the function of nerve and blood coagulation. Methods The patients who were treated with ischemic stroke in our hospital from February 2017 to December 2017 were selected as the research subjects. According to the treatment methods, the patients were divided into the carotid angioplasty stenting (CAS) group (n=45) and the CEA treatment group (n=45). The therapeutic effects of the two groups were observed, and the differences of coagulation function and quality of life between the two groups before and after treatment were compared. Results The effective rate of treatment in the CEA treatment group was 97.78%, which was significantly higher than that of the CAS group (χ2=4.939, P=0.026). The two groups had no difference in coagulation function before treatment. After the treatment, the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer (D-D) in the CEA group were lower than those in the CAS group (t=22.801, 3.752, 6.039, 169.556, P<0.05). There was no difference in the quality of life between the two groups before treatment. After treatment, the quality of life of the CEA treatment group was higher than that of the CAS group (P<0.05). The incidence of high perfusion syndrome, restenosis and hematoma in group CEA was lower than that in group CAS (χ2=4.406, P=0.036). Conclusions CEA has good therapeutic effect on patients with ischemic stroke. It can obviously improve the nerve function and coagulation function of patients, and has a good application value. Key words: Endarterectomy, carotid; Stroke; Neurological function; Coagulation function
目的观察颈动脉内膜切除术(CEA)对缺血性脑卒中患者的治疗效果,并观察其对神经功能及凝血功能的影响。方法选取2017年2月至2017年12月在我院接受缺血性脑卒中治疗的患者作为研究对象。根据治疗方法将患者分为颈动脉成形术支架置入术组(n=45)和CEA治疗组(n=45)。观察两组治疗效果,比较两组治疗前后凝血功能及生活质量的差异。结果CEA治疗组治疗有效率为97.78%,显著高于CAS治疗组(χ2=4.939, P=0.026)。两组治疗前凝血功能无明显差异。治疗后CEA组活性部分凝血活素时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、d -二聚体(D-D)水平均低于CAS组(t=22.801、3.752、6.039、169.556,P<0.05)。治疗前两组患者的生活质量无差异。治疗后,CEA治疗组的生活质量高于CAS组(P<0.05)。CEA组高灌注综合征、再狭窄、血肿发生率低于CAS组(χ2=4.406, P=0.036)。结论CEA对缺血性脑卒中患者有良好的治疗效果。能明显改善患者的神经功能和凝血功能,具有良好的应用价值。关键词:动脉内膜切除术;颈动脉;中风;神经功能;凝血功能
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引用次数: 0
The value of posterior pedicle screw rod system internal fixation in the treatment of degenerative scoliosis 后路椎弓根钉棒系统内固定治疗退行性脊柱侧凸的价值
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20181130-02222
Zhiqiang Liu, Daxiong Feng, Yunlong Zhou, L. Tian, Qingzhong Zhou, Lipeng Zheng
Objective To investigate the clinical value of short segment fusion and long segment fusion combined with posterior pedicle screw system internal fixation in the treatment of degenerative scoliosis. Methods 74 patients with degenerative scoliosis who were treated in the Affiliated Hospital of Southwest Medical University from January 2014 to February 2018 were enrolled in the study. The patients were divided into group A and group B with a random number table of 37 cases each. Group A was treated with short segment fusion and posterior pedicle screw system internal fixation, while group B was with long segment fusion and posterior pedicle screw system internal fixation. The Cobb angle of scoliosis, the balance of coronal and sagittal plane of spine were observed before operation, 1 week after operation, 3 months after operation and 6 months after operation, and the incidence of early and long-term complications were counted. Results The Cobb angle of scoliosis in group B was lower than that of group A at 1 week, 3 months and 6 months after operation (P 0.05). There was significant difference in the balance of coronal plane and sagittal plane between the two groups at 6 months after operation (P 0.05). Conclusions Long segment fusion and posterior pedicle screw system internal fixation can improve the Cobb angle and reduce the incidence of postoperative scoliosis, but it is easy to appear the imbalance of coronal and sagittal planes, which can be selected according to the actual situation. Key words: Pedicle screws; Spinal fusion; Degenerative scoliosis
目的探讨短节段融合与长节段融合联合后路椎弓根螺钉系统内固定治疗退行性脊柱侧凸的临床价值。方法选取2014年1月至2018年2月在西南医科大学附属医院治疗的74例退行性脊柱侧凸患者作为研究对象。将患者随机分为A组和B组,每组37例。A组采用短节段融合后路椎弓根螺钉系统内固定,B组采用长节段融合后路椎弓根螺钉系统内固定。观察术前、术后1周、术后3个月、术后6个月脊柱侧凸Cobb角、冠矢状面平衡情况,并统计早期和远期并发症发生率。结果B组术后1周、3个月、6个月脊柱侧凸的Cobb角均低于A组(P < 0.05)。两组患者术后6个月冠状面、矢状面平衡差异有统计学意义(P < 0.05)。结论长节段融合后路椎弓根螺钉系统内固定可改善Cobb角,降低术后脊柱侧凸发生率,但易出现冠状面与矢状面不平衡,可根据实际情况选择。关键词:椎弓根螺钉;脊柱融合术;退行性脊柱侧凸
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引用次数: 0
Research progress of the pathogenesis of NFPA and the tumorigenicity of COX-2 NFPA发病机制及COX-2致瘤性的研究进展
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20190126-00082
Guodong Zhao, Lingsheng Kong
Non-functioning pituitary adenoma (NFPA), lack of the clinical and biochemical characteristics of hormone overexpression, is a common type of pituitary adenoma. It could bring enormous suffering to the patients on account of the tendentiousness of being invasive macroadenoma and oppressing surrounding tissue. At present, the pathogenesis of NFPA is still unclear, thus there is no effective medical management for the disease. Although transsphenoidal surgery is the first-line treatment for NFPA, it is very difficult to achieve a cure effect. It has been found that the abnormal expression of cyclooxygenase-2 (COX-2) affects the survival and progression of cancer. Recent studies have detected the expression of COX-2 in pituitary tumors, and the expression of COX-2 in NFPA is stronger, suggesting that COX-2 may be involved in the occurrence and development of NFPA. This article reviews the pathogenesis of NFPA and the tumorigenicity of COX-2, and provides new ideas for clinical drug treatment of NFPA. Key words: Cyclooxygenase 2; Non-functioning pituitary adenoma; Pituitary neoplasms; Review
无功能垂体腺瘤(NFPA)是一种常见的垂体腺瘤,缺乏激素过表达的临床和生化特征。由于大腺瘤具有侵袭性和压迫周围组织的倾向,给患者带来极大的痛苦。目前,NFPA的发病机制尚不清楚,因此尚无有效的医学治疗方法。虽然经蝶窦手术是NFPA的一线治疗方法,但很难达到治愈效果。研究发现环氧化酶-2 (COX-2)的异常表达影响肿瘤的生存和进展。近期研究检测到COX-2在垂体肿瘤中的表达,且COX-2在NFPA中的表达更强,提示COX-2可能参与了NFPA的发生发展。本文就NFPA的发病机制及COX-2的致瘤性进行综述,为NFPA的临床药物治疗提供新的思路。关键词:环加氧酶2;无功能垂体腺瘤;垂体肿瘤;审查
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引用次数: 0
Correlation between urinary phthalate concentration and semen quality parameters 尿邻苯二甲酸盐浓度与精液质量参数的相关性研究
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20190201-00112
Linshuang Zhou, Tingting Shan, Wenpin Cai
Objective To explore the correlation between urinary phthalate concentration and semen quality parameters. Methods A total of 112 males with infertility in our hospital were set as infertility group. Another 65 healthy males who had given birth during the same period in our hospital were selected as control group. The semen samples obtained by urine and masturbation were collected in all the subjects. The semen quality parameters were detected by automatic color sperm quality detection system, and the concentrations of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP) and Di 2-Ethyl Hexyl Phthalate (DEHP) in urine were measured by high performance liquid chromatography, and the correlation between concentrations of four phthalates and semen quality parameters was analyzed by spearman correlation coefficient. Results The concentrations of DMP, DEP, DBP, DEHP and total phthalate in infertility group were significantly higher than those in control group (P<0.05). The sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement in infertility group were significantly lower than those in control group (P<0.05), and the ratio of abnormal sperm was significantly higher than that in control group (P<0.05). The concentrations of DMP, DEP, DBP and DEHP in urine were negatively correlated with sperm density, sperm survival rate and ratios of a+ b level sperm and forward movement (P<0.05), and were positively correlated with abnormal sperm ratio (P<0.05). Conclusions The concentration of phthalate is high in urine of infertile males, and its concentration is negatively correlated with semen quality. Phthalate accumulation may be one of the important reasons for male infertility. Key words: Urinalysis; Phthalate; Semen analysis; Infertility, male
目的探讨尿邻苯二甲酸盐浓度与精液质量参数的相关性。方法选择本院112例男性不育症患者作为不育症组。选取同期在我院分娩的健康男性65例作为对照组。所有受试者均采集尿液和手淫精液样本。采用全自动彩色精子质量检测系统检测精液质量参数,采用高效液相色谱法测定尿液中邻苯二甲酸二甲酯(DMP)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二乙酯(DEHP)浓度,并采用spearman相关系数分析4种邻苯二甲酸酯浓度与精液质量参数的相关性。结果不孕症组DMP、DEP、DBP、DEHP及邻苯二甲酸酯总浓度显著高于对照组(P<0.05)。不孕症组精子密度、精子存活率、a+ b水平精子比例和前移率显著低于对照组(P<0.05),异常精子比例显著高于对照组(P<0.05)。尿中DMP、DEP、DBP、DEHP浓度与精子密度、精子存活率、a+ b水平精子比例及向前运动呈负相关(P<0.05),与异常精子比例呈正相关(P<0.05)。结论不育男性尿液中邻苯二甲酸盐浓度较高,且浓度与精液质量呈负相关。邻苯二甲酸酯积累可能是男性不育的重要原因之一。关键词:尿液分析;邻苯二甲酸酯;精液分析;不孕,男
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引用次数: 0
Clinical analysis of risk factors and pregancy outcomes of fetal growth restriction in the third trimester 妊娠晚期胎儿生长受限危险因素及妊娠结局的临床分析
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20181129-02210
ZhaoDong Liu, Jianying Yan, Meimei Guo
Objective The aim of this study is to analyze risk factors and perinatal outcomes of fetal growth restriction (FGR) in the third trimester to improve pregnancy outcomes. Methods The retrospective study collected 676 fetus, included 338 FGR and 338 appropriate for gestational infants. All samples were collected between January 1st 2014 and January 1st 2016 from Fujian Provincial Maternity and Children's Hospital. Multivariate logistic regression analysis was used to analyze the risk factors and pregnancy outcomes of fetal growth restriction between FGR and control group. Results ⑴ Multivariate logistic regression analysis showed that the independent risk factor of FGR was severe preeclampsia for 28-33+ 6 weeks FGR. The independent risk factors of 37-40+ 6 weeks FGR were severe preeclampsia, oligohydramnios, velum attachment of cord and cord around neck. ⑵ Compared with the control group of the same gestational week, the fetal distress rate, 1 minute asphyxia rate of newborn and cesarean section rate of FGR in the 28-33+ 6 gestational week group were all higher than those in the same gestational week group (P<0.05). ⑶ The fetal distress in FGR group was more than in cesarean delivery that in vaginal delivery at 28-33+ 6 weeks of gestation, and that in FGR group was more than that in vaginal delivery at 34-36+ 6 weeks of gestation (P<0.05). Conclusions Severe preeclampsia, oligohydramnios, velum attachment of umbilical cord and cord around the neck are the independent risk factors of FGR in the third trimester. During pregnancy, early intervention such as screening in high risk pregnant women and fetal intrauterine monitoring should be carried out to improve the perinatal outcome. Key words: Pregnancy trimester, third; Fetal growth restriction; Risk factors; Pregnancy outcome
目的分析妊娠晚期胎儿生长受限(FGR)的危险因素及围产儿结局,以改善妊娠结局。方法回顾性研究676例胎儿,其中FGR 338例,适孕儿338例。所有样本于2014年1月1日至2016年1月1日在福建省妇幼医院采集。采用多因素logistic回归分析FGR组与对照组胎儿生长受限的危险因素及妊娠结局。结果⑴多因素logistic回归分析显示FGR的独立危险因素为28 ~ 33+ 6周严重子痫前期。37 ~ 40+ 6周FGR的独立危险因素为重度子痫前期、羊水过少、脐带膜附着及脐带绕颈。⑵与同孕周对照组比较,28 ~ 33+ 6孕周组胎儿窘迫率、新生儿1分钟窒息率、FGR剖宫产率均高于同孕周组(P<0.05)。⑶妊娠28 ~ 33+ 6周FGR组胎儿窘迫发生率高于剖宫产组和阴道分娩组,妊娠34 ~ 36+ 6周FGR组胎儿窘迫发生率高于阴道分娩组(P<0.05)。结论重度子痫前期、羊水过少、脐带膜附着、脐带绕颈是妊娠晚期发生FGR的独立危险因素。妊娠期应进行早期干预,如高危孕妇筛查、胎儿宫内监测等,以改善围产儿结局。关键词:妊娠三个月;胎儿生长限制;风险因素;怀孕的结果
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引用次数: 0
Minimally invasive percutaneous pedicle screw fixation in the treatment of single vertebra magerl type A thoracolumbar fracture 微创经皮椎弓根螺钉内固定治疗单椎体A型胸腰椎骨折
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20181204-02258
W. Feng, Jin Chen, W. Cui
Objective To explore the effect of minimally invasive percutaneous pedicle screw internal fixation on the anterior height and Cobb angle of injured vertebra in patients with single vertebra magerl type A thoracolumbar fracture. Methods 71 cases of single vertebra magerl type A thoracolumbar fracture admitted in our hospital from January 2015 to January 2017 were reviewed. Among them, 31 patients who received minimally invasive percutaneous pedicle screw internal fixation were as the observation group, and 40 patients receiving open pedicle internal fixation were as control group. All the patients were followed up for one year, and the preoperative and postoperative indexes, the height of the anterior edge of the injured vertebra and Cobb angle, as well as the score of Oswestry dysfunction were compared between the two groups. Results The length of incision and the time of descending were shorter in the observation group than in the control group, and the amount of bleeding during operation was less than in the control group (P 0.05). There was no significant difference in serum creatine kinase (CK) and C-reaction protein (CRP) levels between the two groups (P>0.05); the levels of serum CK and CRP in the two groups increased significantly after operation, and those in the control group were significantly higher than those in the observation group (P 0.05); 7 days and 1 year after operation, the height of the anterior edge of the two groups was significantly higher than that before operation (P 0.05). There was no significant difference in Oswestry dysfunction score between the two groups (P>0.05); the scores of Oswestry dysfunction were significantly reduced in both groups 7 days and 1 year ater operation, and the observation group was significantly lower than the control group (P<0.01). Conclusions Minimally invasive percutaneous pedicle screw fixation can effectively improve the anterior height and Cobb angle of the injured vertebra in patients with single vertebra magerl A thoracolumbar fracture, and the perioperative indexes, serum inflammatory factors and Oswestry dysfunction scores are better than those of open pedicle internal fixation, which is worthy of clinical application. Key words: Pedicle screws; Thoracolumbar fracture; Fracture fixation, internal
目的探讨经皮微创椎弓根螺钉内固定对单椎体magerl型A型胸腰椎骨折伤椎前高度和Cobb角的影响。方法回顾性分析我院2015年1月至2017年1月收治的单椎体A型胸腰椎骨折71例。其中31例采用微创经皮椎弓根螺钉内固定作为观察组,40例采用开放式椎弓根内固定作为对照组。随访1年,比较两组患者术前、术后各项指标、损伤椎体前缘高度、Cobb角、Oswestry功能障碍评分。结果观察组切口长度、下降时间均短于对照组,术中出血量少于对照组(P < 0.05)。两组血清肌酸激酶(CK)、c反应蛋白(CRP)水平差异无统计学意义(P>0.05);两组患者术后血清CK、CRP水平均显著升高,且对照组显著高于观察组(P < 0.05);术后7天和1年,两组患者的前缘高度均显著高于术前(P < 0.05)。两组患者Oswestry功能障碍评分差异无统计学意义(P>0.05);两组患者术后7 d、1年Oswestry功能障碍评分均显著降低,且观察组显著低于对照组(P<0.01)。结论经皮微创椎弓根螺钉内固定可有效改善单椎体magerl A胸腰椎骨折患者损伤椎体前高度和Cobb角,围手术期指标、血清炎症因子及Oswestry功能障碍评分均优于开放式椎弓根内固定,值得临床推广应用。关键词:椎弓根螺钉;胸腰椎骨折;骨折内固定
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引用次数: 0
Application progress of laparoscopy in the treatment of liver tumors 腹腔镜技术在肝脏肿瘤治疗中的应用进展
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20200306-00243
Zhiyu Xiao, Chuan-chao He, Jie Wang
Laparoscopy has been used for the treatment of liver tumors for nearly 30 years. Since then, the world's liver surgeon giving a great deal of energy and enthusiasm to this tool, expanding indications and optimizing laparoscopy operation procedures, making indications of laparoscopic liver resection from the edge of liver benign tumors gradually extended to the left lobe, right lobe, left or right anterolateral segmentectomy or posterosuperior segmentectomy, right posterior sectionectomy, central hepatectomy, and extended left/right hepatectomy or caudate lobe. Accompanied by image technology upgrade, energy equipment update and the delicate anatomic stratagem, the security, effectiveness, advantages of laparoscopy in treatment of liver tumor got fully verified recently. There are plenty of basic and clinical research also fully confirmed the perioperative advantage of laparoscopic in liver cancer treatment. For the long-term therapeutic effect, continued case observation and strategy adjustment are still required in future. Key words: Laparoscopy; Hepatectomy; Liver neoplasms
腹腔镜用于肝脏肿瘤的治疗已有近30年的历史。此后,世界肝外科医生对这一工具投入了大量的精力和热情,扩大了适应症,优化了腹腔镜手术程序,使腹腔镜肝切除术的适应症从肝脏良性肿瘤边缘逐渐扩展到左叶、右叶、左或右前外侧节段切除术或后上节段切除术、右后段切除术、中央肝切除术、扩展左/右肝切除术或尾状叶。近年来,伴随着影像技术的升级、能源设备的更新和精细的解剖策略,腹腔镜治疗肝脏肿瘤的安全性、有效性、优越性得到了充分的验证。大量的基础和临床研究也充分证实了腹腔镜在肝癌治疗中的围手术期优势。为了达到长期的治疗效果,今后还需要继续进行病例观察和策略调整。关键词:腹腔镜;肝切除术;肝脏肿瘤
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引用次数: 0
Expressions and clinical significances of miR-15 and miR-29a in serum of patients with diabetic retinopathy miR-15、miR-29a在糖尿病视网膜病变患者血清中的表达及临床意义
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20181220-02388
Ying Lin, Qiwen Li, Xiaomei Lin
Objective To analyze the expression levels of miR-15 and miR-29a in serum of patients with diabetic retinopathy (DR) and their diagnostic values for DR. Methods 155 patients (155 eyes) with type 2 diabetes mellitus (DM) were treated in our hospital from June 2016 to August 2018, according to the occurrence of retinopathy and the degree of retinopathy, the patients were divided into five groups: 50 cases of non-retinopathy group (NDR group), 56 cases of simple retinopathy group (SDR group), 49 cases of proliferative retinopathy group (PDR group) and another 50 healthy persons in the same period were selected as the control group. Triglyceride (TG), total cholesterol (TC), and fasting blood glucose (FPG) were measured. Levels of serum miR-15 and miR-29a were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Pearson correlation method was used to analyze the relationships between levels of serum miR-15 and miR-29a with clinical indicators in DR patients. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic values of miR-15 and miR-29a in DR. Results The relative expression of miR-15 in serum of NDR group, SDR group, and PDR group were lower than that of control group (P<0.05), and the relative expression of miR-15 in NDR group, SDR group, and PDR group decreased gradually (P<0.05); the relative expression of miR-29a in serum of NDR group, SDR group, and PDR group were higher than that of control group (P<0.05), and the mRNA relative expression of miR-29a in NDR group, SDR group, and PDR group increased gradually (P<0.05); the expression of serum miR-15 in DR patients was negatively correlated with urinary albumin/creatinine (UACR), glycosylated hemoglobin (HbA1c) and the course of DM (r=-0.732, -0.492, -0.589, P<0.05); the expression level of miR-29a was positively correlated with UACR, HbA1c and the course of DM (r=0.744, 0.508, 0.556, P<0.05); the areas under the ROC curve (AUC) of miR-15 and miR-29a for DR diagnosis were 0.796 (95% CI: 0.724-0.857) and 0.677 (95% CI: 0.597-0.749), with diagnostic thresholds 0.63 and 1.11, sensitivities 84.9% and 53.8%, specificities 65.3% and 79.6%, repectively; miR-29a was a risk factor for DR, while miR-15 was a protective factor for DR. Conclusions The expression of mir-15 and miR-29a in the serum of DR patients is decreased, which is related to the degree of retinopathy and can be used as biomarkers for early diagnosis of DR. Key words: Diabetic retinopathy; miR-15; miR-29a; Early diagnosis
目的分析糖尿病视网膜病变(DR)患者血清中miR-15和miR-29a的表达水平及其对DR的诊断价值。方法选取2016年6月至2018年8月我院收治的2型糖尿病(DM)患者155例(155眼),根据患者视网膜病变的发生情况及视网膜病变程度将患者分为5组:选取非视网膜病变组(NDR组)50例,单纯性视网膜病变组(SDR组)56例,增殖性视网膜病变组(PDR组)49例,同期健康人50例作为对照组。测定甘油三酯(TG)、总胆固醇(TC)和空腹血糖(FPG)。采用定量逆转录聚合酶链反应(qRT-PCR)检测血清miR-15和miR-29a水平。采用Pearson相关法分析DR患者血清miR-15、miR-29a水平与临床指标的关系。采用受试者工作特征曲线(ROC)评价miR-15和miR-29a在dr中的诊断价值。结果NDR组、SDR组和PDR组血清中miR-15的相对表达量均低于对照组(P<0.05),且NDR组、SDR组和PDR组中miR-15的相对表达量逐渐降低(P<0.05);NDR组、SDR组和PDR组血清中miR-29a的相对表达量均高于对照组(P<0.05), NDR组、SDR组和PDR组miR-29a mRNA的相对表达量逐渐升高(P<0.05);DR患者血清miR-15表达与尿白蛋白/肌酐(UACR)、糖化血红蛋白(HbA1c)及DM病程呈负相关(r=-0.732、-0.492、-0.589,P<0.05);miR-29a表达水平与UACR、HbA1c、DM病程呈正相关(r=0.744、0.508、0.556,P<0.05);miR-15和miR-29a诊断DR的ROC曲线下面积(AUC)分别为0.796 (95% CI: 0.724-0.857)和0.677 (95% CI: 0.597-0.749),诊断阈值分别为0.63和1.11,敏感性分别为84.9%和53.8%,特异性分别为65.3%和79.6%;结论DR患者血清中miR-15、miR-29a的表达降低,与视网膜病变程度有关,可作为DR早期诊断的生物标志物。关键词:糖尿病视网膜病变;miR-15;miR-29a;早期诊断
{"title":"Expressions and clinical significances of miR-15 and miR-29a in serum of patients with diabetic retinopathy","authors":"Ying Lin, Qiwen Li, Xiaomei Lin","doi":"10.3760/CMA.J.CN431274-20181220-02388","DOIUrl":"https://doi.org/10.3760/CMA.J.CN431274-20181220-02388","url":null,"abstract":"Objective \u0000To analyze the expression levels of miR-15 and miR-29a in serum of patients with diabetic retinopathy (DR) and their diagnostic values for DR. \u0000 \u0000 \u0000Methods \u0000155 patients (155 eyes) with type 2 diabetes mellitus (DM) were treated in our hospital from June 2016 to August 2018, according to the occurrence of retinopathy and the degree of retinopathy, the patients were divided into five groups: 50 cases of non-retinopathy group (NDR group), 56 cases of simple retinopathy group (SDR group), 49 cases of proliferative retinopathy group (PDR group) and another 50 healthy persons in the same period were selected as the control group. Triglyceride (TG), total cholesterol (TC), and fasting blood glucose (FPG) were measured. Levels of serum miR-15 and miR-29a were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Pearson correlation method was used to analyze the relationships between levels of serum miR-15 and miR-29a with clinical indicators in DR patients. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic values of miR-15 and miR-29a in DR. \u0000 \u0000 \u0000Results \u0000The relative expression of miR-15 in serum of NDR group, SDR group, and PDR group were lower than that of control group (P<0.05), and the relative expression of miR-15 in NDR group, SDR group, and PDR group decreased gradually (P<0.05); the relative expression of miR-29a in serum of NDR group, SDR group, and PDR group were higher than that of control group (P<0.05), and the mRNA relative expression of miR-29a in NDR group, SDR group, and PDR group increased gradually (P<0.05); the expression of serum miR-15 in DR patients was negatively correlated with urinary albumin/creatinine (UACR), glycosylated hemoglobin (HbA1c) and the course of DM (r=-0.732, -0.492, -0.589, P<0.05); the expression level of miR-29a was positively correlated with UACR, HbA1c and the course of DM (r=0.744, 0.508, 0.556, P<0.05); the areas under the ROC curve (AUC) of miR-15 and miR-29a for DR diagnosis were 0.796 (95% CI: 0.724-0.857) and 0.677 (95% CI: 0.597-0.749), with diagnostic thresholds 0.63 and 1.11, sensitivities 84.9% and 53.8%, specificities 65.3% and 79.6%, repectively; miR-29a was a risk factor for DR, while miR-15 was a protective factor for DR. \u0000 \u0000 \u0000Conclusions \u0000The expression of mir-15 and miR-29a in the serum of DR patients is decreased, which is related to the degree of retinopathy and can be used as biomarkers for early diagnosis of DR. \u0000 \u0000 \u0000Key words: \u0000Diabetic retinopathy; miR-15; miR-29a; Early diagnosis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85505438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic anatomical hepatectomy of hepatic vein approach 腹腔镜解剖肝静脉入路肝切除术
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20200306-00241
X. Teng, Hao Bu, Wei-Chang Cheng
Laparoscopic anatomical hepatectomy of hepatic vein approach is a laparoscopic hepatectomy technique based on anatomical hepatectomy and guided by hepatic vein. It not only can completely remove the focus and retain the structural integrity of the remaining liver tissue, but also has the advantages of less trauma and rapid recovery by laparoscopy. When the transection plane is guided by complete exposure of hepatic vein, the ineffective liver tissue without inflow and outflow tract can be completely removed, the possibility of postoperative tumor recurrence and postoperative complications can be reduced, so as to improve the survival rate of patients. At present, it is of great clinical value and widely carried out. This article will review the development of anatomical hepatectomy of hepatic vein approach and the main points of laparoscopic anatomical hepatectomy of hepatic vein approach. Key words: Laparoscopy; Hepatectomy; Hepatic vein approach
腹腔镜解剖肝静脉入路是一种以解剖肝切除术为基础,以肝静脉为指导的腹腔镜肝切除术技术。它不仅可以完全切除病灶,保留剩余肝组织的结构完整性,而且具有创伤小,腹腔镜下恢复快的优点。横切面以肝静脉完全暴露为引导,可完全切除无流入、流出道的无效肝组织,减少术后肿瘤复发及术后并发症的可能性,提高患者生存率。目前,它具有很大的临床价值,被广泛开展。本文就肝静脉入路解剖肝切除术的发展及腹腔镜肝静脉入路解剖肝切除术的要点作一综述。关键词:腹腔镜;肝切除术;肝静脉入路
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引用次数: 0
Evaluation of the effect of paravertebral block combined with general anesthesia on patients with thoracotomy and its effect on perioperative stress 椎旁阻滞联合全麻对开胸患者围手术期应激的影响
Q4 Medicine Pub Date : 2020-03-20 DOI: 10.3760/CMA.J.CN431274-20181203-02233
null Cairenzhuoma, Yun Wang
Objective To evaluate the effect of subtotal paravertebral block combined with general anesthesia on the application of open thoracic surgery and its effect on perioperative stress. Methods From January 2016 to January 2018, 70 cases of patients who underwent thoracotomy were studied. According to the simple random method, patients were divided into control group and observation group. The control group was given general anesthesia, and the observation group was given thoracic paravertebral nerve combined with general anesthesia. The changes of hemodynamics, anesthetic effect, anesthesia recovery, stress response and adverse reaction during anesthesia were compared between the two groups. Results There was no significant difference in heart rate (HR), mean arterial pressure (MAP) and blood oxygen saturation (SaO2) between the two groups at 1 min after induction, 1 min intubation and 1 min after extubation (P>0.05). The anesthetic effect of the patients in the observation group was better than that of the control group (P 0.05). Conclusions Ultrasound paravertebral block combined with general anesthesia can improve the anesthesia effect, and has better analgesic effect, less postoperative stress response, and high safety. Key words: Ultrasonography; Paravertebral nerve block; Anesthesia, general; Thoracic surgical procedures
目的评价椎旁次全阻滞联合全麻对胸外科手术应用的影响及其对围手术期应激的影响。方法对2016年1月~ 2018年1月行开胸手术的患者70例进行分析。按简单随机法将患者分为对照组和观察组。对照组给予全身麻醉,观察组给予胸椎旁神经联合全身麻醉。比较两组患者麻醉过程中血流动力学、麻醉效果、麻醉恢复、应激反应及不良反应的变化。结果两组患者诱导后1 min、插管后1 min、拔管后1 min的心率(HR)、平均动脉压(MAP)、血氧饱和度(SaO2)比较,差异均无统计学意义(P>0.05)。观察组患者麻醉效果优于对照组(P < 0.05)。结论超声椎旁阻滞联合全麻可提高麻醉效果,镇痛效果好,术后应激反应少,安全性高。关键词:超声检查;椎旁神经阻滞;麻醉,一般;胸外科手术
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引用次数: 0
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中国医师杂志
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