Optimization of floating bilayered tablets of Ketorolac Tromethamine

Abstract

Objective : The aim of the present study was to formulate the floating bilayer tablets of Ketorolac tromethamine, first immediate release layer and second sustained release floating layer which would provide initial loading dose of drug and remain in stomach and upper part of GIT for prolonged period of time in a view to maximize solubility of drug which is necessary for its absorption. Methods : The floating bilayered tablets of Ketorolac tromethamine were prepared by using 3 2 factorial designs by direct compression method. For this, polymers like sodium starch glycolate and polyox WSR 303 were used in various concentrations. Sodium bicarbonate was used as a floating effervescent agent. The formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time, % CDR etc Results : From the result obtained, S3 having 23 % Polyox WSR 303 and 12 % sodium bicarbonate showed better results. Conclusions : The results showed that Polyox WSR is promising tool to designing of sustained release formulation.