Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies

A. Domínguez, M. Bayó, J. Muñoz-Rodríguez, J. Bellido, J. M. Abascal-Junquera, N. Hannaoui, Josep Maria Banús
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引用次数: 1

Abstract

Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
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化学发光分析解决血清前列腺特异性抗原值的反复虚假升高:可能受到嗜异性抗体的干扰
嗜异性抗体是针对各种动物抗原的人免疫球蛋白。在分析不同的肿瘤标志物,包括前列腺特异性抗原时,它们会产生假阳性结果。在某些情况下,这种干扰可能导致误诊、不必要的检查和过度治疗。我们在此报告一例52岁男性前列腺特异性抗原反复假升高,达到108.7 ng/mL的水平,怀疑是由嗜异性抗体引起的。通过改变分析技术解决了干扰问题。前列腺特异性抗原真实值均小于1 ng/mL。
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