Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.791
T. Grenader, L. Shavit
Purpose Although angiogenesis has been implicated in the promotion of renal cyst growth in autosomal dominant polycystic kidney disease, no studies have investigated the role of angiogenesis in the growth of simple renal cysts. The aim of current study was to investigate the effect of chemotherapy with the antivascular endothelial growth factor antibody bevacizumab on renal cyst development and growth in cancer patients. Materials and Methods We retrospectively reviewed the medical records of 136 patients with a variety of cancers that were treated with bevacizumab-based chemotherapy for metastatic disease. The presence of and changes in renal cysts were evaluated by retrospective analysis of computed tomography scans performed for assessment of tumor response to bevacizumab-based therapy. Results The median age of the patients was 64 years. Renal cysts were identified in 66 patients, in whom 33 (50%) had a single cyst and the rest had 2 or more cysts. The average dose of bevacizumab was 2.68 mg/kg per week. Median duration of treatment was 33 weeks. Average cyst size was 1.9±2.4 cm at the beginning of the study and the majority of the cysts (54 patients, 84%) did not change in size or shape during bevacizumab treatment. No patients were identified with new cysts. Cyst size changed in 10 patients (16%): an increase of 15% to 40% from the baseline size in 5 patients and a decrease in size of 10% to 70% in another 5 patients. The duration of bevacizumab therapy was significantly longer in the subgroup of patients with diminished or increased cyst size than in the patients with stable cyst size: 62 weeks versus 29 weeks, respectively (p=0.0002). Conclusions Our data demonstrated that simple renal cysts were stable in size and number in the vast majority of cancer patients treated with bevacizumab.
{"title":"Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy","authors":"T. Grenader, L. Shavit","doi":"10.4111/kju.2015.56.12.791","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.791","url":null,"abstract":"Purpose Although angiogenesis has been implicated in the promotion of renal cyst growth in autosomal dominant polycystic kidney disease, no studies have investigated the role of angiogenesis in the growth of simple renal cysts. The aim of current study was to investigate the effect of chemotherapy with the antivascular endothelial growth factor antibody bevacizumab on renal cyst development and growth in cancer patients. Materials and Methods We retrospectively reviewed the medical records of 136 patients with a variety of cancers that were treated with bevacizumab-based chemotherapy for metastatic disease. The presence of and changes in renal cysts were evaluated by retrospective analysis of computed tomography scans performed for assessment of tumor response to bevacizumab-based therapy. Results The median age of the patients was 64 years. Renal cysts were identified in 66 patients, in whom 33 (50%) had a single cyst and the rest had 2 or more cysts. The average dose of bevacizumab was 2.68 mg/kg per week. Median duration of treatment was 33 weeks. Average cyst size was 1.9±2.4 cm at the beginning of the study and the majority of the cysts (54 patients, 84%) did not change in size or shape during bevacizumab treatment. No patients were identified with new cysts. Cyst size changed in 10 patients (16%): an increase of 15% to 40% from the baseline size in 5 patients and a decrease in size of 10% to 70% in another 5 patients. The duration of bevacizumab therapy was significantly longer in the subgroup of patients with diminished or increased cyst size than in the patients with stable cyst size: 62 weeks versus 29 weeks, respectively (p=0.0002). Conclusions Our data demonstrated that simple renal cysts were stable in size and number in the vast majority of cancer patients treated with bevacizumab.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"2 1","pages":"791 - 795"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82109297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.789
Kwangsung Park
The Korean Journal of Urology (KJU) will change its name starting in 2016. Recently, the editorial board of the KJU had a spirited discussion about whether to keep the original name or change it to attract more international authors and readers of our journal. In 2014, approximately 60% of the papers submitted to the KJU were from outside of Korea, and the number of countries represented by authorship totaled around 20, reflecting that the KJU has become an international journal [1,2]. Furthermore, the KJU is currently indexed in major international databases, such as MEDLINE, PubMed, PubMed Central, Web of Science, Scopus, Embase, and EBSCO. Therefore, the editorial board of the KJU and the council of the Korean Urological Association decided to open our gates internationally by changing the name of the journal in our 2015 Annual Meeting of the Korean Urological Association held in Seoul, Korea, on November 18th to 20th. Looking back at the history of the KJU, the official journal of the Korean Urological Association was first published as the 'Taehan Pinyogikwa Hakhoe chapchi' in 1960 and changed to 'Taehan Pinyogikwa Hakhoe chi' (ISSN 0494-4747) in 1979. It was renamed the 'Korean Journal of Urology' (print ISSN 2005-6737; online ISSN 2005-6745) in February 2009 to increase its exposure to a wider international audience. The cover design of the KJU has changed 3 times (Fig. 1). The journal title of the first and second edition of the KJU was in Chinese characters, which changed to Korean in the 3rd edition in 1998. However, the subtitles of the KJU were expressed as the Korean Journal of Urology in English from the 1st edition. In February 2009, the KJU changed its cover design and the title of the journal to English. Finally, the KJU became an English-language journal from the January issue of 2010. Fig. 1 The cover designs of the Korean Journal of Urology from the beginning to the current issues. In the age of high-speed internet and a rapidly changing world, we need to break down the walls of nationalities. Therefore, we found it a perfect time to change the name of the KJU. Even though the KJU will change its name starting in 2016, the editorial board and publisher will continue with the vision and volume number of the KJU. On behalf of the editorial board of the KJU, I would like to express my sincere thanks to the members of the Korean Urological Association and our international readers for their contributions to the KJU. We hope you continue to support and contribute to our journal. All the best!
韩国泌尿外科杂志(KJU)将从2016年开始更名。最近,为了吸引更多的国际作者和读者,韩国大学编辑委员会就是否保留原名称或更改名称进行了激烈的讨论。2014年,KJU投稿的论文中约有60%来自韩国以外的国家,作者代表的国家总数约为20个,反映出KJU已成为一份国际性期刊[1,2]。此外,KJU目前已被MEDLINE、PubMed、PubMed Central、Web of Science、Scopus、Embase和EBSCO等主要国际数据库收录。因此,在11月18日至20日在韩国首尔举行的2015年韩国泌尿外科学会年会上,韩国泌尿学会编委会和韩国泌尿外科学会理事会决定,通过更改期刊名称,向国际打开我们的大门。回顾韩国泌尿学会的历史,1960年大韩泌尿学会的正式期刊《大韩泌尿学会学刊》首次出版,1979年更名为《大韩泌尿学会学刊》(ISSN 0494-4747)。它被重新命名为“韩国泌尿学杂志”(印刷ISSN 2005-6737;在线ISSN 2005-6745),以增加其在更广泛的国际读者中的曝光率。《韩国大学》的封面设计经历了3次变化(图1)。《韩国大学》第1、2版的期刊名称是汉字,1998年第3版改为韩文。但是,从第1版开始,《韩国泌尿外科杂志》的英文字幕就变成了“Korean Journal of Urology”。2009年2月,韩国大学将杂志的封面设计和标题改为英文。最终,《韩国大学》从2010年1月开始成为英文期刊。图1《韩国泌尿学杂志》创刊号至当期封面设计。在高速互联网和快速变化的世界的时代,我们需要打破民族的围墙。因此,我们认为这是更改KJU名称的最佳时机。虽然将从2016年开始改名,但编委会和出版社将继续沿用韩国大学的宗旨和书号。我谨代表大韩泌尿学会编辑委员会,向大韩泌尿学会会员和我们的国际读者对大韩泌尿学会的贡献表示衷心的感谢。我们希望您继续支持和贡献我们的期刊。祝一切顺利!
{"title":"The legend of the KJU","authors":"Kwangsung Park","doi":"10.4111/kju.2015.56.12.789","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.789","url":null,"abstract":"The Korean Journal of Urology (KJU) will change its name starting in 2016. Recently, the editorial board of the KJU had a spirited discussion about whether to keep the original name or change it to attract more international authors and readers of our journal. In 2014, approximately 60% of the papers submitted to the KJU were from outside of Korea, and the number of countries represented by authorship totaled around 20, reflecting that the KJU has become an international journal [1,2]. Furthermore, the KJU is currently indexed in major international databases, such as MEDLINE, PubMed, PubMed Central, Web of Science, Scopus, Embase, and EBSCO. Therefore, the editorial board of the KJU and the council of the Korean Urological Association decided to open our gates internationally by changing the name of the journal in our 2015 Annual Meeting of the Korean Urological Association held in Seoul, Korea, on November 18th to 20th. \u0000 \u0000Looking back at the history of the KJU, the official journal of the Korean Urological Association was first published as the 'Taehan Pinyogikwa Hakhoe chapchi' in 1960 and changed to 'Taehan Pinyogikwa Hakhoe chi' (ISSN 0494-4747) in 1979. It was renamed the 'Korean Journal of Urology' (print ISSN 2005-6737; online ISSN 2005-6745) in February 2009 to increase its exposure to a wider international audience. \u0000 \u0000The cover design of the KJU has changed 3 times (Fig. 1). The journal title of the first and second edition of the KJU was in Chinese characters, which changed to Korean in the 3rd edition in 1998. However, the subtitles of the KJU were expressed as the Korean Journal of Urology in English from the 1st edition. In February 2009, the KJU changed its cover design and the title of the journal to English. Finally, the KJU became an English-language journal from the January issue of 2010. \u0000 \u0000 \u0000 \u0000Fig. 1 \u0000 \u0000The cover designs of the Korean Journal of Urology from the beginning to the current issues. \u0000 \u0000 \u0000 \u0000In the age of high-speed internet and a rapidly changing world, we need to break down the walls of nationalities. Therefore, we found it a perfect time to change the name of the KJU. Even though the KJU will change its name starting in 2016, the editorial board and publisher will continue with the vision and volume number of the KJU. \u0000 \u0000On behalf of the editorial board of the KJU, I would like to express my sincere thanks to the members of the Korean Urological Association and our international readers for their contributions to the KJU. We hope you continue to support and contribute to our journal. \u0000 \u0000All the best!","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"2 1","pages":"789 - 790"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90749548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.823
Chang Ahn, J. Bae, K. Lee, Hae Won Lee
Purpose The definition of posttransobturator tape procedure (post-TOT) voiding dysfunction (VD) is inconsistent in the literature. In this study, we retrospectively investigated the risk factors for post-TOT VD by applying various definitions in one cohort. Materials and Methods The medical records of 449 patients were evaluated postoperatively. Acute urinary retention requiring catheterization, subjective feeling of voiding difficulty during follow-up, and postoperative postvoid residual (PVR) greater than 100 mL or PVR greater than 50% of voided volume (significant PVR) were adopted for the definition of VD. With these categories, multivariate analysis was performed for risk factors of postoperative VD. Results Ten patients (2.2%) required catheterization, 47 (10.5%) experienced postoperative voiding difficulty, and 63 (14.7%) showed significant PVR. In the multivariate logistic analysis, independent risk factors for postoperative retention requiring catheterization were previous retention history (p=0.06) and preoperative history of hysterectomy. Risk factors for subjective postoperative voiding difficulty were underactive detrusor (p=0.04) and preoperative obstructive voiding symptoms (p<0.01). Previous urinary retention history (p<0.01)) was an independent risk factor for concomitant postoperative voiding difficulty and significant PVR. Spinal anesthesia (p=0.02) and previous urinary retention history (p=0.02) were independent risk factors for significant postoperative PVR. Conclusions With the use of several definitions of VD after the midurethral sling procedure, postoperative peak flow rate and PVR were significantly different between groups. Although there were no independent risk factors consistent with various definitions of VD, preoperative obstructive voiding symptoms and objective parameters suggesting impaired detrusor tend to have predictive power for post-TOT VD.
{"title":"Analysis of voiding dysfunction after transobturator tape procedure for stress urinary incontinence","authors":"Chang Ahn, J. Bae, K. Lee, Hae Won Lee","doi":"10.4111/kju.2015.56.12.823","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.823","url":null,"abstract":"Purpose The definition of posttransobturator tape procedure (post-TOT) voiding dysfunction (VD) is inconsistent in the literature. In this study, we retrospectively investigated the risk factors for post-TOT VD by applying various definitions in one cohort. Materials and Methods The medical records of 449 patients were evaluated postoperatively. Acute urinary retention requiring catheterization, subjective feeling of voiding difficulty during follow-up, and postoperative postvoid residual (PVR) greater than 100 mL or PVR greater than 50% of voided volume (significant PVR) were adopted for the definition of VD. With these categories, multivariate analysis was performed for risk factors of postoperative VD. Results Ten patients (2.2%) required catheterization, 47 (10.5%) experienced postoperative voiding difficulty, and 63 (14.7%) showed significant PVR. In the multivariate logistic analysis, independent risk factors for postoperative retention requiring catheterization were previous retention history (p=0.06) and preoperative history of hysterectomy. Risk factors for subjective postoperative voiding difficulty were underactive detrusor (p=0.04) and preoperative obstructive voiding symptoms (p<0.01). Previous urinary retention history (p<0.01)) was an independent risk factor for concomitant postoperative voiding difficulty and significant PVR. Spinal anesthesia (p=0.02) and previous urinary retention history (p=0.02) were independent risk factors for significant postoperative PVR. Conclusions With the use of several definitions of VD after the midurethral sling procedure, postoperative peak flow rate and PVR were significantly different between groups. Although there were no independent risk factors consistent with various definitions of VD, preoperative obstructive voiding symptoms and objective parameters suggesting impaired detrusor tend to have predictive power for post-TOT VD.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"15 1","pages":"823 - 830"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87383110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.831
S. Kim, Y. Kim, I. Cho, S. Min
Purpose To analyze the differences of semen parameters in Korean young population for three periods from 2002 to 2013. Materials and Methods A total of 516 semen samples were collected from Korean men presenting for infertility, varicoceles or other infectious problems for three periods from 2002 to 2012: January 2002-December 2003, January 2007-December 2008, and January 2012-December 2013. A standard World Health Organization procedure for semen analysis was performed for assessment of semen concentration, volume, motility, morphology, and pH. Results A total of 160, 162, 194 men constituted the study populations in 2002 to 2003, in 2007 to 2008, and in 2012 to 2013, respectively. The overall sperm parameter results suggested a statistically significant difference between 2002 to 2003 and 2012 to 2013 except pH. However, considering the data from 2007 to 2008, there were no trends in changes in overall semen parameters. Negative correlations were observed in all semen parameters with increasing age in all patients, except for pH. In addition, semen volume, motility, and morphology had higher negative correlation coefficients with age, from 2002 to 2013, serially. Conclusions There were no significant changes in the semen parameters of Korean men from 2002 to 2013. In addition, semen volume, motility, and morphology showed higher negative correlation coefficients with age from 2002 to 2013, serially.
{"title":"Semen parameters from 2002 to 2013 in Korea young population: A preliminary report","authors":"S. Kim, Y. Kim, I. Cho, S. Min","doi":"10.4111/kju.2015.56.12.831","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.831","url":null,"abstract":"Purpose To analyze the differences of semen parameters in Korean young population for three periods from 2002 to 2013. Materials and Methods A total of 516 semen samples were collected from Korean men presenting for infertility, varicoceles or other infectious problems for three periods from 2002 to 2012: January 2002-December 2003, January 2007-December 2008, and January 2012-December 2013. A standard World Health Organization procedure for semen analysis was performed for assessment of semen concentration, volume, motility, morphology, and pH. Results A total of 160, 162, 194 men constituted the study populations in 2002 to 2003, in 2007 to 2008, and in 2012 to 2013, respectively. The overall sperm parameter results suggested a statistically significant difference between 2002 to 2003 and 2012 to 2013 except pH. However, considering the data from 2007 to 2008, there were no trends in changes in overall semen parameters. Negative correlations were observed in all semen parameters with increasing age in all patients, except for pH. In addition, semen volume, motility, and morphology had higher negative correlation coefficients with age, from 2002 to 2013, serially. Conclusions There were no significant changes in the semen parameters of Korean men from 2002 to 2013. In addition, semen volume, motility, and morphology showed higher negative correlation coefficients with age from 2002 to 2013, serially.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"4 1","pages":"831 - 836"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79199684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.847
A. Kabir, A. Cyrus
To the editor: We express our special thanks for these nice comments on our published paper in your journal [1]. Our study was done before the release of the mentioned new guidelines in 2015 [2]. Moreover, there are studies that have also studied different outcomes (effect) of different durations of these medications on benign prostatic hyperplasia [3,4,5]. We were not able to study the maximal effect for more than 3 months. Because of the lack of previous studies with our design, we preferred to run a study with a shorter duration. In addition, our study was a cohort based on the present data and not a clinical trial with an arbitrary duration of study. Our treatment regimen contained both medications and we did not have a cohort of persons receiving only one of these medications. Perhaps in a factorial clinical trial with different groups consisting of only one of these medications, their combination and placebo could be useful for evaluation of the effect of each regimen. Surely, our results cannot be assumed to refer to only one of these medications but to their combination. In response to the comment, "In addition, the clinical effects of 5ARIs are seen after a minimum treatment duration of at least 6 to 12 months," we should note that in our study, the effects of combination therapy had been observed with a shorter duration. It may be that combination therapy is more effective with a shorter duration and that the effect of combination therapy with both finasteride and prazosin is different from their single treatment effect. Finally, our study was a clinical study and not a basic evaluation of the hormones. Accordingly, we prefer to not discuss these issues, even though the authors' opinions about hormonal pathways and changes seem logical. We think that these issues need a separate study evaluating the effect of all single or combination therapies on biochemical, hormonal, and enzymatic changes.
{"title":"The authors reply: Impact of metabolic syndrome on response to medical treatment of benign prostatic hyperplasia","authors":"A. Kabir, A. Cyrus","doi":"10.4111/kju.2015.56.12.847","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.847","url":null,"abstract":"To the editor: \u0000 \u0000We express our special thanks for these nice comments on our published paper in your journal [1]. Our study was done before the release of the mentioned new guidelines in 2015 [2]. Moreover, there are studies that have also studied different outcomes (effect) of different durations of these medications on benign prostatic hyperplasia [3,4,5]. We were not able to study the maximal effect for more than 3 months. Because of the lack of previous studies with our design, we preferred to run a study with a shorter duration. In addition, our study was a cohort based on the present data and not a clinical trial with an arbitrary duration of study. \u0000 \u0000Our treatment regimen contained both medications and we did not have a cohort of persons receiving only one of these medications. Perhaps in a factorial clinical trial with different groups consisting of only one of these medications, their combination and placebo could be useful for evaluation of the effect of each regimen. Surely, our results cannot be assumed to refer to only one of these medications but to their combination. \u0000 \u0000In response to the comment, \"In addition, the clinical effects of 5ARIs are seen after a minimum treatment duration of at least 6 to 12 months,\" we should note that in our study, the effects of combination therapy had been observed with a shorter duration. It may be that combination therapy is more effective with a shorter duration and that the effect of combination therapy with both finasteride and prazosin is different from their single treatment effect. \u0000 \u0000Finally, our study was a clinical study and not a basic evaluation of the hormones. Accordingly, we prefer to not discuss these issues, even though the authors' opinions about hormonal pathways and changes seem logical. We think that these issues need a separate study evaluating the effect of all single or combination therapies on biochemical, hormonal, and enzymatic changes.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"20 1","pages":"847 - 848"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72655657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.845
M. Kadıhasanoğlu, E. Ozbek
therapy with an α-blocker and 5α-reductase inhibitor (5ARI) after a 3-month period of therapy. Although the mean prostate volume of the patients with MetS was significantly higher than that that of the controls, significant differences in the International Prostate Symptom Score and its components were shown between patients with and without MetS. The authors suggested with this finding that MetS negatively affected the clinical response of BPH to medical treatment. Hyperinsulinemia in patients with BPH might have increased sympathetic nervous system activity, which contributes to an increase of prostate smooth muscle tone [2]. Selective α1-blockers reduce urethral closure resistance and inhibit smooth muscle tone in the prostate and are the firstline medical treatment option for men with BPH. 5ARIs block the conversion of testosterone to dihydrotestosterone and are approved for the treatment of BPH. The duration of treatment with finasteride in the study was 3 months. In the European Association of Urology Guidelines, which include benign prostatic obstruction, it
{"title":"Letter to the editor: Impact of metabolic syndrome on response to medical treatment of benign prostatic hyperplasia","authors":"M. Kadıhasanoğlu, E. Ozbek","doi":"10.4111/kju.2015.56.12.845","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.845","url":null,"abstract":"therapy with an α-blocker and 5α-reductase inhibitor (5ARI) after a 3-month period of therapy. Although the mean prostate volume of the patients with MetS was significantly higher than that that of the controls, significant differences in the International Prostate Symptom Score and its components were shown between patients with and without MetS. The authors suggested with this finding that MetS negatively affected the clinical response of BPH to medical treatment. Hyperinsulinemia in patients with BPH might have increased sympathetic nervous system activity, which contributes to an increase of prostate smooth muscle tone [2]. Selective α1-blockers reduce urethral closure resistance and inhibit smooth muscle tone in the prostate and are the firstline medical treatment option for men with BPH. 5ARIs block the conversion of testosterone to dihydrotestosterone and are approved for the treatment of BPH. The duration of treatment with finasteride in the study was 3 months. In the European Association of Urology Guidelines, which include benign prostatic obstruction, it","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"11 3","pages":"845 - 846"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72606705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-12-01DOI: 10.4111/kju.2015.56.12.811
F. Sharifiaghdas, A. Daneshpajooh, M. Mirzaei
Purpose To evaluate the medium-term efficacy and safety of transobturator four-arm polypropylene mesh in the treatment of high-stage anterior vaginal wall prolapse and concomitant stress urinary incontinence (SUI). Materials and Methods Between September 2010 and August 2013, a prospective single-center trial was performed to evaluate women with stage≥3 anterior vaginal wall prolapse with or without SUI who presented to Labbafinejad Hospital, Teheran, Iran, and underwent anterior vaginal wall repair with polypropylene mesh. Pre- and postoperative evaluation included history; physical examination using the Pelvic Organ Prolapse Quantification system and cough stress test, both before and after reduction of prolapsed structures; Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ); urinalysis and culture; and a postvoid residual assessment. Complications were reported at a mean of 2 years of follow-up. Results A total of 71 patients underwent cystocele repair with the transobturator four-arm polypropylene mesh. Seven of the patients were lost to follow-up. There were no perioperative complications. The anatomical success rate was 87.5%. The subjective success rate was 92.1%. The PFDI and PFIQ were significantly improved after surgery (p<0.001). Among those with the simultaneous complaint of SUI, 82% were cured without any additional procedure. Three patients (4.6%) experienced vaginal mesh extrusion. Two patients (3.1%) reported worsening of dyspareunia after surgery. Conclusions The four arms polypropylene mesh is an effective device for simultaneous correction of anterior vaginal wall prolapse and SUI with a low complication rate at a medium-term follow-up. The majority of the subgroup with concomitant SUI were cured without a second simultaneous procedure.
{"title":"Simultaneous treatment of anterior vaginal wall prolapse and stress urinary incontinence by using transobturator four arms polypropylene mesh","authors":"F. Sharifiaghdas, A. Daneshpajooh, M. Mirzaei","doi":"10.4111/kju.2015.56.12.811","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.811","url":null,"abstract":"Purpose To evaluate the medium-term efficacy and safety of transobturator four-arm polypropylene mesh in the treatment of high-stage anterior vaginal wall prolapse and concomitant stress urinary incontinence (SUI). Materials and Methods Between September 2010 and August 2013, a prospective single-center trial was performed to evaluate women with stage≥3 anterior vaginal wall prolapse with or without SUI who presented to Labbafinejad Hospital, Teheran, Iran, and underwent anterior vaginal wall repair with polypropylene mesh. Pre- and postoperative evaluation included history; physical examination using the Pelvic Organ Prolapse Quantification system and cough stress test, both before and after reduction of prolapsed structures; Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ); urinalysis and culture; and a postvoid residual assessment. Complications were reported at a mean of 2 years of follow-up. Results A total of 71 patients underwent cystocele repair with the transobturator four-arm polypropylene mesh. Seven of the patients were lost to follow-up. There were no perioperative complications. The anatomical success rate was 87.5%. The subjective success rate was 92.1%. The PFDI and PFIQ were significantly improved after surgery (p<0.001). Among those with the simultaneous complaint of SUI, 82% were cured without any additional procedure. Three patients (4.6%) experienced vaginal mesh extrusion. Two patients (3.1%) reported worsening of dyspareunia after surgery. Conclusions The four arms polypropylene mesh is an effective device for simultaneous correction of anterior vaginal wall prolapse and SUI with a low complication rate at a medium-term follow-up. The majority of the subgroup with concomitant SUI were cured without a second simultaneous procedure.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"136 1","pages":"811 - 816"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80499948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-26DOI: 10.4111/kju.2015.56.12.796
Tae Sun Kim, K. Ko, S. Shin, H. Ryoo, W. Song, H. Sung, D. Han, B. Jeong, S. Seo, S. Jeon, Kyu-Sung Lee, S. W. Lee, H. Lee, H. Choi, H. Jeon
Purpose To investigate the differences in the cancer detection rate and pathological findings on a second prostate biopsy according to benign diagnosis, high-grade prostatic intraepithelial neoplasia (HGPIN), and atypical small acinar proliferation (ASAP) on first biopsy. Materials and Methods We retrospectively reviewed the records of 1,323 patients who underwent a second prostate biopsy between March 1995 and November 2012. We divided the patients into three groups according to the pathologic findings on the first biopsy (benign diagnosis, HGPIN, and ASAP). We compared the cancer detection rate and Gleason scores on second biopsy and the unfavorable disease rate after radical prostatectomy among the three groups. Results A total of 214 patients (16.2%) were diagnosed with prostate cancer on a second biopsy. The rate of cancer detection was 14.6% in the benign diagnosis group, 22.1% in the HGPIN group, and 32.1% in the ASAP group, respectively (p<0.001). When patients were divided into subgroups according to the number of positive cores, the rate of cancer detection was 16.7%, 30.5%, 31.0%, and 36.4% in patients with a single core of HGPIN, more than one core of HGPIN, a single core of ASAP, and more than one core of ASAP, respectively. There were no significant differences in Gleason scores on second biopsy (p=0.324) or in the unfavorable disease rate after radical prostatectomy among the three groups (benign diagnosis vs. HGPIN, p=0.857, and benign diagnosis vs. ASAP, p=0.957, respectively). Conclusions Patients with multiple cores of HGPIN or any core number of ASAP on a first biopsy had a significantly higher cancer detection rate on a second biopsy. Repeat biopsy should be considered and not be delayed in those patients.
{"title":"Multiple cores of high grade prostatic intraepithelial neoplasia and any core of atypia on first biopsy are significant predictor for cancer detection at a repeat biopsy","authors":"Tae Sun Kim, K. Ko, S. Shin, H. Ryoo, W. Song, H. Sung, D. Han, B. Jeong, S. Seo, S. Jeon, Kyu-Sung Lee, S. W. Lee, H. Lee, H. Choi, H. Jeon","doi":"10.4111/kju.2015.56.12.796","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.796","url":null,"abstract":"Purpose To investigate the differences in the cancer detection rate and pathological findings on a second prostate biopsy according to benign diagnosis, high-grade prostatic intraepithelial neoplasia (HGPIN), and atypical small acinar proliferation (ASAP) on first biopsy. Materials and Methods We retrospectively reviewed the records of 1,323 patients who underwent a second prostate biopsy between March 1995 and November 2012. We divided the patients into three groups according to the pathologic findings on the first biopsy (benign diagnosis, HGPIN, and ASAP). We compared the cancer detection rate and Gleason scores on second biopsy and the unfavorable disease rate after radical prostatectomy among the three groups. Results A total of 214 patients (16.2%) were diagnosed with prostate cancer on a second biopsy. The rate of cancer detection was 14.6% in the benign diagnosis group, 22.1% in the HGPIN group, and 32.1% in the ASAP group, respectively (p<0.001). When patients were divided into subgroups according to the number of positive cores, the rate of cancer detection was 16.7%, 30.5%, 31.0%, and 36.4% in patients with a single core of HGPIN, more than one core of HGPIN, a single core of ASAP, and more than one core of ASAP, respectively. There were no significant differences in Gleason scores on second biopsy (p=0.324) or in the unfavorable disease rate after radical prostatectomy among the three groups (benign diagnosis vs. HGPIN, p=0.857, and benign diagnosis vs. ASAP, p=0.957, respectively). Conclusions Patients with multiple cores of HGPIN or any core number of ASAP on a first biopsy had a significantly higher cancer detection rate on a second biopsy. Repeat biopsy should be considered and not be delayed in those patients.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"1 1","pages":"796 - 802"},"PeriodicalIF":0.0,"publicationDate":"2015-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80152617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-26DOI: 10.4111/kju.2015.56.12.803
Hansol Lee, Ki Bom Kim, Sangchul Lee, Sang Wook Lee, Myong Kim, S. Cho, Seung-June Oh, S. Jeong
Purpose We compared bladder and urethral functions following radical prostatectomy (RP) between men with and without urinary incontinence (UI), using a large-scale database from SNU-experts-of-urodynamics-leading (SEOUL) Study Group. Materials and Methods Since July 2004, we have prospectively collected data on urodynamics from 303 patients with lower urinary tract symptoms (LUTS) following RP at three affiliated hospitals of SEOUL Study Group. After excluding 35 patients with neurogenic abnormality, pelvic irradiation after surgery, or a history of surgery on the lower urinary tract, 268 men were evaluated. We compared the urodynamic findings between men who had LUTS with UI (postprostatectomy incontinence [PPI] group) and those who had LUTS without UI (non-PPI group). Results The mean age at an urodynamic study was 68.2 years. Overall, a reduced bladder compliance (≤20 mL/cmH2O) was shown in 27.2% of patients; and 31.3% patients had idiopathic detrusor overactivity. The patients in the PPI group were older (p=0.001) at an urodynamic study and had a lower maximum urethral closure pressure (MUCP) (p<0.001), as compared with those in the non-PPI group. Bladder capacity and detrusor pressure during voiding were also significantly lower in the PPI group. In the logistic regression, only MUCP and maximum cystometric capacity were identified as the related factor with the presence of PPI. Conclusions In our study, significant number of patients with LUTS following RP showed a reduced bladder compliance and detrusor overactivity. PPI is associated with both impairment of the urethral closuring mechanism and bladder storage dysfunction.
{"title":"Urodynamic assessment of bladder and urethral function among men with lower urinary tract symptoms after radical prostatectomy: A comparison between men with and without urinary incontinence","authors":"Hansol Lee, Ki Bom Kim, Sangchul Lee, Sang Wook Lee, Myong Kim, S. Cho, Seung-June Oh, S. Jeong","doi":"10.4111/kju.2015.56.12.803","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.803","url":null,"abstract":"Purpose We compared bladder and urethral functions following radical prostatectomy (RP) between men with and without urinary incontinence (UI), using a large-scale database from SNU-experts-of-urodynamics-leading (SEOUL) Study Group. Materials and Methods Since July 2004, we have prospectively collected data on urodynamics from 303 patients with lower urinary tract symptoms (LUTS) following RP at three affiliated hospitals of SEOUL Study Group. After excluding 35 patients with neurogenic abnormality, pelvic irradiation after surgery, or a history of surgery on the lower urinary tract, 268 men were evaluated. We compared the urodynamic findings between men who had LUTS with UI (postprostatectomy incontinence [PPI] group) and those who had LUTS without UI (non-PPI group). Results The mean age at an urodynamic study was 68.2 years. Overall, a reduced bladder compliance (≤20 mL/cmH2O) was shown in 27.2% of patients; and 31.3% patients had idiopathic detrusor overactivity. The patients in the PPI group were older (p=0.001) at an urodynamic study and had a lower maximum urethral closure pressure (MUCP) (p<0.001), as compared with those in the non-PPI group. Bladder capacity and detrusor pressure during voiding were also significantly lower in the PPI group. In the logistic regression, only MUCP and maximum cystometric capacity were identified as the related factor with the presence of PPI. Conclusions In our study, significant number of patients with LUTS following RP showed a reduced bladder compliance and detrusor overactivity. PPI is associated with both impairment of the urethral closuring mechanism and bladder storage dysfunction.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"1 1","pages":"803 - 810"},"PeriodicalIF":0.0,"publicationDate":"2015-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86566806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-26DOI: 10.4111/kju.2015.56.12.817
Chang-Yong Lee, C. Kim, W. J. Cho
Purpose We aimed to analyze the characteristics of urinary retention (UR) in female inpatients managed with medical treatments. Materials and Methods We retrospectively analyzed the medical records of female inpatients referred to the department of urology for UR at our institution from January 2009, to December 2014. UR was defined as a difficulty in self-voiding despite a sufficient urine volume or >300-mL postvoid residual. The data included patients' age, body mass index (BMI), ambulatory status, medical and surgical history, classes of taking drugs, and urinary tract infection. Results A total of 182 women were included as retention group, mean age of 72.64±12.94 years and BMI of 22.94±3.10 kg/m2. In the chi-square analysis, cardiovascular disorders (p=0.000), diabetes mellitus (p=0.008), metastatic malignancy (p=0.008), chronic renal disorders (p=0.028) were found significantly. In the multiple logistic regression analysis, cardiovascular disorders (p=0.002; odds ratio [OR], 0.491), metastatic malignancy (p=0.013; OR, 2.616) were found to increase the risk of UR. The most common surgical history was anti-incontinence surgery (7.2%). In term of medication use, the most prescribed agents were nonsteroidal anti-inflammatory drugs (NSAIDs) (53.8%). The patients taking multiple drugs with antimuscarinic effects except of NSAIDs, narcotics and diuretics were 48 (26.4%). Urinary tract infection was identified in 43 patients (23.6%). Conclusions UR in females managed with medical treatments could be occurred occasionally. We think that thorough attentions are needed for UR to patients with cardiovascular disorders including diabetes mellitus, metastatic malignancy, chronic renal disorders urinary tract infection, and more careful interests when managing with drugs with antimuscarinic effects.
{"title":"Characteristics of urinary retention in female inpatients managed with medical treatments","authors":"Chang-Yong Lee, C. Kim, W. J. Cho","doi":"10.4111/kju.2015.56.12.817","DOIUrl":"https://doi.org/10.4111/kju.2015.56.12.817","url":null,"abstract":"Purpose We aimed to analyze the characteristics of urinary retention (UR) in female inpatients managed with medical treatments. Materials and Methods We retrospectively analyzed the medical records of female inpatients referred to the department of urology for UR at our institution from January 2009, to December 2014. UR was defined as a difficulty in self-voiding despite a sufficient urine volume or >300-mL postvoid residual. The data included patients' age, body mass index (BMI), ambulatory status, medical and surgical history, classes of taking drugs, and urinary tract infection. Results A total of 182 women were included as retention group, mean age of 72.64±12.94 years and BMI of 22.94±3.10 kg/m2. In the chi-square analysis, cardiovascular disorders (p=0.000), diabetes mellitus (p=0.008), metastatic malignancy (p=0.008), chronic renal disorders (p=0.028) were found significantly. In the multiple logistic regression analysis, cardiovascular disorders (p=0.002; odds ratio [OR], 0.491), metastatic malignancy (p=0.013; OR, 2.616) were found to increase the risk of UR. The most common surgical history was anti-incontinence surgery (7.2%). In term of medication use, the most prescribed agents were nonsteroidal anti-inflammatory drugs (NSAIDs) (53.8%). The patients taking multiple drugs with antimuscarinic effects except of NSAIDs, narcotics and diuretics were 48 (26.4%). Urinary tract infection was identified in 43 patients (23.6%). Conclusions UR in females managed with medical treatments could be occurred occasionally. We think that thorough attentions are needed for UR to patients with cardiovascular disorders including diabetes mellitus, metastatic malignancy, chronic renal disorders urinary tract infection, and more careful interests when managing with drugs with antimuscarinic effects.","PeriodicalId":17819,"journal":{"name":"Korean Journal of Urology","volume":"171 1","pages":"817 - 822"},"PeriodicalIF":0.0,"publicationDate":"2015-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90229441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}