Synthesis and In vitro Testing of Novel Quinoline Derivatives and for Cancer Cells

Abstract

Quinoline and its derivatives represent an important class of nitrogen containing heterocycles because they are useful intermediates in organic synthesis and biological activities such as antiasthmatic, anti-inflammatory, anti- cancer, and antimalarial activity. A quinoline containing eight compounds was successfully synthesized and characterized by FT-IR, 1H NMR, 13C NMR and mass spectral analysis. Therefore, the synthesis of new quinoline derivatives with strong pharmacological activity is important in medicine. There is significant research focused on the development of new quinoline-based structures and new methods of synthesis. In this research study, new quinoline derivatives were synthesized and the synthesized compounds were characterized by several spectroscopic techniques, the biological activity of these compounds was evaluated using lung cancer cell lines and molecular modeling in an enzymatic system. The synthesized eight new compounds were tested for their potential activity in lung cancer cell lines. Eight synthesized compounds (K1- K8) were evaluated for their cytotoxic activities. The anticancer test showed that the quinoline compounds K2, K3 and K4 show good anticancer activity. Among them, K2 and K4 were shown to be dose-dependent, with K4 having the highest toxicity at 250 µM and K8 having the highest toxicity at 125, 250, and 500 µM, while K1, K2, K5, K6, and K7 were not cytotoxic.