Pub Date : 2024-07-26DOI: 10.26452/ijrps.v15i3.4681
Soaib Ahmed, Souvik Kundu, Rahul Patra, Jaydip Ray
Change control plays a role in cGMP, just as all aspects of quality management should continually strive for enhancement. It works with a prior mechanism that empowers designated personnel across fields to assess, as well as having permission to authorize proposing or doing modifications that would impact the status that was prevalidated for the process system, including facilities, systems, and equipment. Change management involves overseeing changes in staff, protocols, operations, and product standards. These changes can occur in areas such as manufacturing, quality control, quality assurance, engineering, research and development (R&D), and marketing. Depending on their significance, changes may be categorized as critical, major, or minor; they may also be classified as emergency, planned, or unplanned based on their nature. Effective change management encompasses the coordination of personnel resources along with protocols to ensure consistency in operations and product excellence. It is a component of GMP compliance, as regulatory bodies mandate companies to demonstrate proficiency in managing changes. The process entails initiating a change request, followed by evaluating its impact on the product before devising an action plan for implementation, ultimately culminating with the Change Control Board (CCB) making decisions regarding the proposed changes.
{"title":"Change Control from Initiation to Implementation in the Pharmaceutical Industry: A Comprehensive Review","authors":"Soaib Ahmed, Souvik Kundu, Rahul Patra, Jaydip Ray","doi":"10.26452/ijrps.v15i3.4681","DOIUrl":"https://doi.org/10.26452/ijrps.v15i3.4681","url":null,"abstract":"Change control plays a role in cGMP, just as all aspects of quality management should continually strive for enhancement. It works with a prior mechanism that empowers designated personnel across fields to assess, as well as having permission to authorize proposing or doing modifications that would impact the status that was prevalidated for the process system, including facilities, systems, and equipment. Change management involves overseeing changes in staff, protocols, operations, and product standards. These changes can occur in areas such as manufacturing, quality control, quality assurance, engineering, research and development (R&D), and marketing. Depending on their significance, changes may be categorized as critical, major, or minor; they may also be classified as emergency, planned, or unplanned based on their nature. Effective change management encompasses the coordination of personnel resources along with protocols to ensure consistency in operations and product excellence. It is a component of GMP compliance, as regulatory bodies mandate companies to demonstrate proficiency in managing changes. The process entails initiating a change request, followed by evaluating its impact on the product before devising an action plan for implementation, ultimately culminating with the Change Control Board (CCB) making decisions regarding the proposed changes.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"22 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.26452/ijrps.v15i2.4680
Subashree Ilangovan, Selvi A
Effective and safe induction of labour is crucial in modern obstetric practice. This study aims to compare the efficacy and safety of sublingual misoprostol versus dinoprostone gel in inducing labour. A prospective, randomized controlled trial was conducted at a tertiary care hospital. A total of 828 pregnant women requiring labour induction were randomly assigned to receive either sublingual misoprostol (n=414) or dinoprostone gel (n=414). The primary outcome was the success rate of labour induction, defined as vaginal delivery within 24 hours. Secondary outcomes included the time interval from induction to delivery, incidence of hyperstimulation syndrome, mode of delivery, and maternal and neonatal outcomes. Data were analyzed using SPSS, with statistical significance set at p
有效而安全的引产在现代产科实践中至关重要。本研究旨在比较舌下含服米索前列醇和地诺前列酮凝胶引产的有效性和安全性。一项前瞻性随机对照试验在一家三级医院进行。共有828名需要引产的孕妇被随机分配接受舌下含服米索前列醇（414人）或地诺前列酮凝胶（414人）。主要结果是引产成功率，即在24小时内经阴道分娩。次要结果包括从引产到分娩的时间间隔、过度刺激综合征的发生率、分娩方式以及产妇和新生儿的预后。数据采用 SPSS 进行分析，统计显著性设定为 p
{"title":"Comparative Study of Sublingual Misoprostol and Dinoprostone Gel in Labour Induction and Its Implication on Maternal and Neonatal Outcome","authors":"Subashree Ilangovan, Selvi A","doi":"10.26452/ijrps.v15i2.4680","DOIUrl":"https://doi.org/10.26452/ijrps.v15i2.4680","url":null,"abstract":"Effective and safe induction of labour is crucial in modern obstetric practice. This study aims to compare the efficacy and safety of sublingual misoprostol versus dinoprostone gel in inducing labour. A prospective, randomized controlled trial was conducted at a tertiary care hospital. A total of 828 pregnant women requiring labour induction were randomly assigned to receive either sublingual misoprostol (n=414) or dinoprostone gel (n=414). The primary outcome was the success rate of labour induction, defined as vaginal delivery within 24 hours. Secondary outcomes included the time interval from induction to delivery, incidence of hyperstimulation syndrome, mode of delivery, and maternal and neonatal outcomes. Data were analyzed using SPSS, with statistical significance set at p","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Health professionals and consumers are increasingly urging food corporations to produce healthier options, leading to a rise in the popularity of gluten-free flours like millet, sweet potatoes, and mung bean flour. Nutraceutical muffins offer a novel approach by combining the enjoyment of a tasty snack with the health benefits of bioactive compounds. These muffins are formulated with ingredients such as mung bean flour, spinach powder, guava powder, jaggery, and ghee to provide dietary fiber, vitamins, minerals, and antioxidants. Gluten-free and suitable for diabetics, they also address health concerns such as energy enhancement, vitamin deficiency, constipation, and bone health. In conclusion, nutraceutical muffins present an exciting way to merge health and flavor, making functional ingredients easily accessible in daily diets. However, further research is needed to optimize their formulation and validate their health benefits.
{"title":"Nutraceutical Muffins: Development and Sensory Evaluation","authors":"Bhatt Mehul K, Goswami Dhruvi, Rajgor Hiral, Patel Devanshi, Vora Jahanavee, Talaviya Priti, Shah Nehal","doi":"10.26452/ijrps.v15i3.4679","DOIUrl":"https://doi.org/10.26452/ijrps.v15i3.4679","url":null,"abstract":"Health professionals and consumers are increasingly urging food corporations to produce healthier options, leading to a rise in the popularity of gluten-free flours like millet, sweet potatoes, and mung bean flour. Nutraceutical muffins offer a novel approach by combining the enjoyment of a tasty snack with the health benefits of bioactive compounds. These muffins are formulated with ingredients such as mung bean flour, spinach powder, guava powder, jaggery, and ghee to provide dietary fiber, vitamins, minerals, and antioxidants. Gluten-free and suitable for diabetics, they also address health concerns such as energy enhancement, vitamin deficiency, constipation, and bone health. In conclusion, nutraceutical muffins present an exciting way to merge health and flavor, making functional ingredients easily accessible in daily diets. However, further research is needed to optimize their formulation and validate their health benefits.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141829068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-29DOI: 10.26452/ijrps.v15i1.4664
Govindarajan A, Swetha Ns, Govind Shaji, P. S
This systematic review comprehensively analyzes the literature on hypotensive anesthesia in Functional Endoscopic Sinus Surgeries (FESS), crucial for treating sinonasal disorders. The anesthesia technique choice significantly influences FESS outcomes. Hypotensive anesthesia, involving controlled blood pressure reduction during surgery, garners attention for potential benefits. A database search identified relevant studies examining its efficacy, safety, and impact on intraoperative visibility, surgical time, blood loss, and postoperative outcomes. Various drugs, including inhalational agents, hypocapnia, hypercapnia, local adrenaline, fentanyl, remifentanil, esmolol, dexmedetomidine, and nitroglycerine, have been employed to minimize bleeding and enhance operative conditions. Sevoflurane is a common inhalation agent. Dexmedetomidine, with lower bolus doses, proves advantageous for visibility and achieving a MAP of 60 mm Hg swiftly. Opioids have a lower hypotensive potential, nitroglycerine lacks analgesic effects, and beta-blockers provide favorable conditions. Dexmedetomidine's prolonged analgesia correlates with improved postoperative outcomes. Limited studies explore combined drugs' efficacy or side effects. Cognitive dysfunction is a concern, with hypotension approved up to a MAP of 60 mm Hg. The technique's application extends to children, but careful patient selection is crucial, considering contraindications and comorbidities.
这篇系统性综述全面分析了功能性内窥镜鼻窦手术（FESS）中的低血压麻醉文献，FESS 是治疗鼻窦疾病的关键。麻醉技术的选择在很大程度上影响着 FESS 的效果。低血压麻醉是指在手术过程中控制血压的降低，因其潜在的益处而备受关注。通过数据库搜索发现了相关研究，这些研究探讨了低血压麻醉的有效性、安全性以及对术中可见度、手术时间、失血量和术后效果的影响。各种药物，包括吸入剂、低碳酸血症、高碳酸血症、局部肾上腺素、芬太尼、瑞芬太尼、艾司洛尔、右美托咪定和硝酸甘油，都被用来减少出血和改善手术条件。七氟醚是一种常用的吸入剂。右美托咪定的栓剂剂量较低，在能见度和迅速达到 MAP 60 mm Hg 方面具有优势。阿片类药物的降压潜能较低，硝酸甘油缺乏镇痛作用，而β-受体阻滞剂则提供了有利条件。右美托咪定可延长镇痛时间，从而改善术后效果。有关联合用药的疗效或副作用的研究有限。认知功能障碍是一个令人担忧的问题，血压最高可达 60 mm Hg。该技术适用于儿童，但考虑到禁忌症和合并症，谨慎选择患者至关重要。
{"title":"Hypotensive Anaesthesia in Functional Endoscopic Sinus Surgeries: A Systematic Review","authors":"Govindarajan A, Swetha Ns, Govind Shaji, P. S","doi":"10.26452/ijrps.v15i1.4664","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4664","url":null,"abstract":"This systematic review comprehensively analyzes the literature on hypotensive anesthesia in Functional Endoscopic Sinus Surgeries (FESS), crucial for treating sinonasal disorders. The anesthesia technique choice significantly influences FESS outcomes. Hypotensive anesthesia, involving controlled blood pressure reduction during surgery, garners attention for potential benefits. A database search identified relevant studies examining its efficacy, safety, and impact on intraoperative visibility, surgical time, blood loss, and postoperative outcomes. Various drugs, including inhalational agents, hypocapnia, hypercapnia, local adrenaline, fentanyl, remifentanil, esmolol, dexmedetomidine, and nitroglycerine, have been employed to minimize bleeding and enhance operative conditions. Sevoflurane is a common inhalation agent. Dexmedetomidine, with lower bolus doses, proves advantageous for visibility and achieving a MAP of 60 mm Hg swiftly. Opioids have a lower hypotensive potential, nitroglycerine lacks analgesic effects, and beta-blockers provide favorable conditions. Dexmedetomidine's prolonged analgesia correlates with improved postoperative outcomes. Limited studies explore combined drugs' efficacy or side effects. Cognitive dysfunction is a concern, with hypotension approved up to a MAP of 60 mm Hg. The technique's application extends to children, but careful patient selection is crucial, considering contraindications and comorbidities.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4663
Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M
Our study focused on comparing the efficacy of Rubber Band Ligation (banding), a day-care and cost-effective procedure, with conventional haemorrhoidectomy in the treatment of haemorrhoids. The study included 120 patients diagnosed through proctoscopic examination, with 60 assigned to each group. Patients were randomly selected through simple alternation for banding or haemorrhoidectomy after receiving procedural explanations and providing consent. Banding, utilizing Barron's band applicator and Hemoband suction device under local anaesthesia, demonstrated notable advantages. Comparison parameters included bleeding, pain, prolapse, and overall relief during follow-ups. Banding showed significantly lower bleeding persistence at 4 weeks compared to haemorrhoidectomy (p < 0.001). Prolapse rates were comparable between the two groups (10%). Complete relief was observed in 1.66% of patients in both groups at the first follow-up (p = 0.929). Banding resulted in moderate pain levels compared to haemorrhoidectomy. Hospital stay duration favoured banding, with 71.66% discharged in 1-3 days, while haemorrhoidectomy had longer stays (3-6 days: 26.66%, >6 days: 1.66%). In conclusion, Rubber Band Ligation emerged as a more effective and preferable method for second-degree haemorrhoids, providing better outcomes, reduced bleeding, and shorter hospital stays compared to conventional haemorrhoidectomy.
{"title":"Comparative study of rubber band ligation versus surgical excision in the treatment of second-degree haemorrhoids","authors":"Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4663","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4663","url":null,"abstract":"Our study focused on comparing the efficacy of Rubber Band Ligation (banding), a day-care and cost-effective procedure, with conventional haemorrhoidectomy in the treatment of haemorrhoids. The study included 120 patients diagnosed through proctoscopic examination, with 60 assigned to each group. Patients were randomly selected through simple alternation for banding or haemorrhoidectomy after receiving procedural explanations and providing consent. Banding, utilizing Barron's band applicator and Hemoband suction device under local anaesthesia, demonstrated notable advantages. Comparison parameters included bleeding, pain, prolapse, and overall relief during follow-ups. Banding showed significantly lower bleeding persistence at 4 weeks compared to haemorrhoidectomy (p < 0.001). Prolapse rates were comparable between the two groups (10%). Complete relief was observed in 1.66% of patients in both groups at the first follow-up (p = 0.929). Banding resulted in moderate pain levels compared to haemorrhoidectomy. Hospital stay duration favoured banding, with 71.66% discharged in 1-3 days, while haemorrhoidectomy had longer stays (3-6 days: 26.66%, >6 days: 1.66%). In conclusion, Rubber Band Ligation emerged as a more effective and preferable method for second-degree haemorrhoids, providing better outcomes, reduced bleeding, and shorter hospital stays compared to conventional haemorrhoidectomy.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"12 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4660
Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M
This prospective observational study, conducted at the Department of General Surgery, SRM Medical College and Hospital, aimed to assess the effectiveness of tissue culture and sensitivity compared to swab culture and sensitivity in the healing of diabetic foot ulcers through antibiotic sensitivity of microorganisms. Between May 2016 and August 2017, 160 subjects with diabetic foot ulcers were randomly assigned treatment based on either swab or tissue culture findings. Patients were followed at 15-day intervals for up to 60 days. Results showed positive swab cultures in 76.88% and positive tissue cultures in 92.50% of the study population. The most prevalent organism in swab cultures was Proteus (14.38%), while Pseudomonas (16.88%) dominated in tissue cultures. The cumulative proportion of subjects developing granulation tissue was faster in the tissue culture group, reaching 57.50% at 15 to 30 days and 99% at 31 to 45 days. The swab culture group exhibited proportions of 48.80%, 75%, and 93.80% at the same intervals. In conclusion, diabetic foot ulcer treatment based on tissue culture showed slightly faster healing rates compared to swab culture. However, both groups achieved good ulcer healing within the 60-day follow-up period. These findings emphasize the importance of choosing an appropriate culture method for effective management of diabetic foot ulcers.
{"title":"Comparative study of tissue culture and sensitivity versus swab culture and sensitivity of microorganisms in the healing of diabetic foot ulcers","authors":"Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4660","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4660","url":null,"abstract":"This prospective observational study, conducted at the Department of General Surgery, SRM Medical College and Hospital, aimed to assess the effectiveness of tissue culture and sensitivity compared to swab culture and sensitivity in the healing of diabetic foot ulcers through antibiotic sensitivity of microorganisms. Between May 2016 and August 2017, 160 subjects with diabetic foot ulcers were randomly assigned treatment based on either swab or tissue culture findings. Patients were followed at 15-day intervals for up to 60 days. Results showed positive swab cultures in 76.88% and positive tissue cultures in 92.50% of the study population. The most prevalent organism in swab cultures was Proteus (14.38%), while Pseudomonas (16.88%) dominated in tissue cultures. The cumulative proportion of subjects developing granulation tissue was faster in the tissue culture group, reaching 57.50% at 15 to 30 days and 99% at 31 to 45 days. The swab culture group exhibited proportions of 48.80%, 75%, and 93.80% at the same intervals. In conclusion, diabetic foot ulcer treatment based on tissue culture showed slightly faster healing rates compared to swab culture. However, both groups achieved good ulcer healing within the 60-day follow-up period. These findings emphasize the importance of choosing an appropriate culture method for effective management of diabetic foot ulcers.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"100 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4661
Suman Lata, Sonia Dhiman, Mamta Rana
Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.
{"title":"Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation","authors":"Suman Lata, Sonia Dhiman, Mamta Rana","doi":"10.26452/ijrps.v15i1.4661","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4661","url":null,"abstract":"Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"20 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4661
Suman Lata, Sonia Dhiman, Mamta Rana
Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.
{"title":"Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation","authors":"Suman Lata, Sonia Dhiman, Mamta Rana","doi":"10.26452/ijrps.v15i1.4661","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4661","url":null,"abstract":"Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"139 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4662
T. Seal, B. Pillai, K. Chaudhuri
Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.
{"title":"Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants","authors":"T. Seal, B. Pillai, K. Chaudhuri","doi":"10.26452/ijrps.v15i1.4662","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4662","url":null,"abstract":"Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.26452/ijrps.v15i1.4662
T. Seal, B. Pillai, K. Chaudhuri
Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.
{"title":"Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants","authors":"T. Seal, B. Pillai, K. Chaudhuri","doi":"10.26452/ijrps.v15i1.4662","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4662","url":null,"abstract":"Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"68 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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