Inhibitory effect of Sumu (Lignum Sappan) plus Fuzi (Radix Aconiti Lateralis Praeparata) on a lung carcinoma model

IF 2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-04-01 DOI:10.1016/j.jtcm.2018.03.007

Zhang Hewei, Ma Shuran, Tian Tian, Xu Ya, Zhao Dandan, Wang Tong, Hou Chunying, Zhang Shujing

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引用次数: 3

Abstract

OBJECTIVE

To investigate the inhibitory effect of Sumu (Lignum Sappan) plus Fuzi (Radix Aconiti Lateralis Praeparata) (SF) on the growth and metastasis of Lewis lung carcinoma.

METHODS

A lung carcinoma model was established by subcutaneously inoculating Lewis lung carcinoma cells into C57BL/6 mice. The mice were randomly divided into four groups of 13 mice (control, low-dose, moderate-dose, and high-dose), and gavaged once-daily for 21 consecutive days. The rates of tumor inhibition, metastasis, and metastasis inhibition were observed. The differential expressions of sP-selectin and vascular endothelial growth factor C (VEGFC) were compared between the treatment groups and the control group.

RESULTS

The tumor weights differed significantly between the treatment groups and the control group (P < 0.05). Administration of SF in the moderate-dosage and low-dose groups significantly inhibited the expression of sP-selectin and VEGFC (both P < 0.05), suggesting anti-tumor activity.

CONCLUSION

SF can inhibit the growth and metastasis of Lewis lung carcinoma.

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苏木加附子对肺癌模型的抑制作用

目的探讨苏木联合附子对Lewis肺癌生长和转移的抑制作用。方法采用Lewis肺癌细胞皮下接种C57BL/6小鼠建立sa肺癌模型。将小鼠随机分为对照组、低剂量组、中剂量组、高剂量组4组，每组13只，每天灌胃1次，连续灌胃21 d。观察肿瘤抑制率、转移率和转移抑制率。比较治疗组与对照组sp -选择素和血管内皮生长因子C (VEGFC)的表达差异。结果治疗组与对照组肿瘤重量差异有统计学意义(P <0.05)。中、低剂量组SF均显著抑制sp -选择素和VEGFC的表达(P <0.05)，提示具有抗肿瘤活性。结论sf具有抑制Lewis肺癌生长和转移的作用。

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来源期刊

Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

2.40

自引率

3.80%

发文量

32269

审稿时长

2 months

期刊介绍： Journal of Traditional Chinese Medicine（JTCM） is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.