Protective effect of aqueous extract of Xylopia aethiopica fruits on carbon tetrachloride-induced nephrotoxicity in rats

O. Adewale, N. Orhue
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引用次数: 2

Abstract

Objectives: The burden of renal diseases is growing every day, and there is need to speed up research toward realizing the goal of a safe, cheap, and readily available remedy against this scourge. The objective of the study was to investigate the protective effect of aqueous extract of the fruit of Xylopia aethiopica against carbon tetrachloride (CCl4 )-induced kidney damage in rats. Materials and Methods: Thirty-six rats divided into 6 groups were used for the investigation. Group I served as control, Groups II, III, and IV were pre-treated for 21 days with aqueous extract of the fruit of X. aethiopica at doses of 250, 500, and 1000 mg/kg body weight, respectively, prior to a single intraperitoneal administration of CCl4 . Animals in groups V received only the fruit extract at a dose of 1000 mg/kg body weight while animals in group VI were given only CCl4 . Animals were sacrificed 24 h after the administration of CCl4 . The kidney function tests were performed in addition to histopathological evaluations. Results: Significant increase in the plasma levels of creatinine and urea, and a significant decrease in plasma total protein and albumin following CCl4 administration were detected. CCl4 caused a significant elevation in malondialdehyde and a decrease in the activities of the antioxidant enzymes in the kidney. These deleterious effects were significantly prevented by pre-treatment with the X. aethiopica extract. Conclusion: These findings suggest that X. aethiopica protection of the kidney against CCl4 -induced damage may be connected with the rich antioxidant potential of the plant.
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木果水提物对四氯化碳所致大鼠肾毒性的保护作用
目标:肾脏疾病的负担每天都在增加,有必要加快研究,以实现安全、廉价和容易获得的治疗这一祸害的目标。本研究旨在探讨青木果水提物对四氯化碳(CCl4)所致大鼠肾损伤的保护作用。材料与方法:将36只大鼠分为6组进行研究。第1组作为对照组,第2、3、4组分别以250、500、1000 mg/kg体重的剂量用埃塞俄比亚锥虫果实水提取物预处理21天,然后单次腹腔注射CCl4。V组只给予1000mg /kg体重的水果提取物,而VI组只给予CCl4。给药24 h后处死动物。除组织病理学检查外,还进行了肾功能检查。结果:CCl4给药后血浆肌酐和尿素水平显著升高,血浆总蛋白和白蛋白水平显著降低。CCl4引起肾脏中丙二醛显著升高和抗氧化酶活性降低。这些有害的影响可以通过用埃塞俄比亚锥虫提取物进行预处理而得到明显的抑制。结论:这些研究结果提示,衣索匹对CCl4诱导的肾脏损伤的保护作用可能与其丰富的抗氧化潜能有关。
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