State of cellular and humoral systemic immunity in women of reproductive age under the development of proliferative processes in the endometry of the uterus and breast glands

Abstract

The immune system plays an important role in the pathogenesis of endometrial hyperplasia (EH) and benign breast tumors, as in the body of women this system interacts closely with the reproductive system. Due to the fact that the transformation of endometrial cells and mammary glands is controlled by the immune system, it is important to study the redistribution of components of cellular and humoral immune components in women with combined pathology. The aim of the study was to study the state of cellular and humoral parts of the immune system in women of reproductive age, patients with endometrial hyperplasia and benign breast tumors. Materials and methods. Studies of the state of the immune cell were performed in peripheral blood to determine the subpopulation composition of blood lymphocytes using monoclonal antibodies to antigens CD3 + (total number of T lymphocytes), CD4 + (T-helpers), CD8 + (T-suppressors), CD16 + (NK cells), CD19 + (B-lymphocytes). Indicators of humoral immunity - immunoglobulins (Ig) of classes A, M and G were determined using monospecific sera against these immunoglobulins. Results of the research. There was a decrease in the mean values of T-lymphocytes, T-suppressors, T-helpers and B-lymphocytes with a simultaneous increase in NK cells in the peripheral blood in patients with GE and mastopathy compared with the control group. There was a decrease in the immunoregulatory index - the ratio of CD4 + / CD8 +. An increase in the content of Ig G and a decrease in the levels of Ig M and Ig A in the groups of patients with GE and in the combination of GE and mastopathy in comparison with healthy women is shown. Conclusions. Immunological homeostasis, which is characterized by changes in cellular and humoral immunity at the systemic level, is involved in the violation of reproductive function in women with hormonal imbalance, which leads to the development of GE and mastopathy