Pub Date : 2024-03-27DOI: 10.15587/2519-4798.2024.298207
Dmytro Dubenko
The aim. To analyze the clinical case of surgical treatment of a patient with a pilonidal cyst (PC) of the sacrococcygeal area, which manifested as an anterior perianal abscess, and to justify the need for an in-depth differential and diagnostic search in patients with corresponding clinical manifestations of perianal pathology. Description of a clinical case. The article describes a clinical case of successful treatment of a 24-year-old patient with a pilonidal cyst of the sacrococcygeal area and a purulent secondary fistula that mimicked a perianal abscess with an incomplete external fistula of the rectum. Data are given on the step-by-step performance of the diagnostic process and the choice of optimal surgical treatment tactics. Results and discussion. The described clinical case is interesting for specialists and its detailed coverage due to: a) the presented atypical course of PC; b) selected diagnostic tactics; c) the selected method of operative treatment of the patient. The points mentioned above are described in detail in the section, with coverage and visualization of possible alternative options for the patient's diagnosis and the use of various tactics for surgical treatment. Conclusions. Conducting an extended differential diagnostic search using additional instrumental imaging methods is justified in patients with pilonidal disease with an atypical or blurred course. Performing a complete perioperative set of examinations allows for choosing the correct surgical tactics for treating such patients. The use of a full-fledged invasive examination of the perianal area using methods of regional or general anesthesia is reasonably justified in case of suspicion of insufficient informativeness of clinical-instrumental, laboratory, and imaging methods of examination
目的分析对一名骶尾部皮样囊肿（PC）患者进行手术治疗的临床病例，该病例表现为肛周前部脓肿，并说明对有相应肛周病变临床表现的患者进行深入鉴别诊断的必要性。文章描述了一例成功治疗 24 岁患者的临床病例，该患者患有骶尾部朝天鼻囊肿，继发化脓性瘘管，模仿肛周脓肿并伴有直肠不完全外瘘。文中提供了有关诊断过程的步骤和最佳手术治疗策略选择的数据。所描述的临床病例对专家来说非常有趣，其详细内容包括：a) PC 的非典型病程；b) 所选择的诊断策略；c) 所选择的患者手术治疗方法。本节对上述各点进行了详细描述，并对患者诊断的可能替代方案以及手术治疗的各种策略的使用进行了覆盖和可视化。对于病程不典型或模糊的念珠菌病患者，使用其他仪器成像方法进行扩展鉴别诊断搜索是合理的。进行一整套围手术期检查，可以为这类患者选择正确的手术治疗策略。如果怀疑临床-仪器、实验室和成像检查方法的信息量不足，则有理由使用区域或全身麻醉方法对肛周进行全面的侵入性检查。
{"title":"Sacrococcygeal pilonidal cyst with the disease onset as an anterior perianal abscess: a clinical case","authors":"Dmytro Dubenko","doi":"10.15587/2519-4798.2024.298207","DOIUrl":"https://doi.org/10.15587/2519-4798.2024.298207","url":null,"abstract":"The aim. To analyze the clinical case of surgical treatment of a patient with a pilonidal cyst (PC) of the sacrococcygeal area, which manifested as an anterior perianal abscess, and to justify the need for an in-depth differential and diagnostic search in patients with corresponding clinical manifestations of perianal pathology.\u0000Description of a clinical case. The article describes a clinical case of successful treatment of a 24-year-old patient with a pilonidal cyst of the sacrococcygeal area and a purulent secondary fistula that mimicked a perianal abscess with an incomplete external fistula of the rectum. Data are given on the step-by-step performance of the diagnostic process and the choice of optimal surgical treatment tactics.\u0000Results and discussion. The described clinical case is interesting for specialists and its detailed coverage due to: a) the presented atypical course of PC; b) selected diagnostic tactics; c) the selected method of operative treatment of the patient. The points mentioned above are described in detail in the section, with coverage and visualization of possible alternative options for the patient's diagnosis and the use of various tactics for surgical treatment.\u0000Conclusions. Conducting an extended differential diagnostic search using additional instrumental imaging methods is justified in patients with pilonidal disease with an atypical or blurred course. Performing a complete perioperative set of examinations allows for choosing the correct surgical tactics for treating such patients. The use of a full-fledged invasive examination of the perianal area using methods of regional or general anesthesia is reasonably justified in case of suspicion of insufficient informativeness of clinical-instrumental, laboratory, and imaging methods of examination","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"16 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.15587/2519-4798.2024.298556
V.O. Kolisnyk, Y. Odynets
Wheezing is the most common clinical symptom of bronchial obstructive syndrome. The functions of pulmonary surfactant (PS) depend directly on the level of total phospholipids (TP). This can be used to assess the integrity of the cell membrane structure. Objective. To determine the level of total phospholipids and calcium in exhaled breath condensate in young children with recurrent wheezing and asthma. Materials and methods. The study included 77 patients divided into 3 groups. Group 1 included 30 patients (20 girls and 10 boys) with no more than 2 episodes of recurrent wheezing in their lifetime; Group 2 -10 patients (6 boys and 4 girls) with more than 3 episodes of recurrent wheezing, and 37 patients (15 girls, 22 boys) with asthma. The control group consisted of 20 conditionally healthy children (11 girls, 9 boys). All patients were aged from 3 months to 6 years. The determination of phospholipid levels and calcium (Ca) in the exhaled breath condensate was performed in dynamics - during the period of clinical manifestations and remission. Results. The level of phospholipids in the exhaled breath condensate was the highest in patients of all groups at the stage of clinical manifestations compared with the period of remission, while its lowest level was noted in the control group. During the peak of the disease, the level of Ca in the exhaled breath condensate was significantly lower compared to the period of remission. The control group had the highest level. Conclusions. The exhaled breath condensate's high level of phospholipids in the first days of the disease confirms cell damage in the presence of inflammation. Additionally, the exhaled breath condensate's Ca level is lowest during this period, possibly indicating its involvement in cell damage
{"title":"Analysis of exhaled breath condensate in patients with asthma and recurrent wheezing","authors":"V.O. Kolisnyk, Y. Odynets","doi":"10.15587/2519-4798.2024.298556","DOIUrl":"https://doi.org/10.15587/2519-4798.2024.298556","url":null,"abstract":"Wheezing is the most common clinical symptom of bronchial obstructive syndrome. The functions of pulmonary surfactant (PS) depend directly on the level of total phospholipids (TP). This can be used to assess the integrity of the cell membrane structure. \u0000Objective. To determine the level of total phospholipids and calcium in exhaled breath condensate in young children with recurrent wheezing and asthma. \u0000Materials and methods. The study included 77 patients divided into 3 groups. Group 1 included 30 patients (20 girls and 10 boys) with no more than 2 episodes of recurrent wheezing in their lifetime; Group 2 -10 patients (6 boys and 4 girls) with more than 3 episodes of recurrent wheezing, and 37 patients (15 girls, 22 boys) with asthma. The control group consisted of 20 conditionally healthy children (11 girls, 9 boys). All patients were aged from 3 months to 6 years. The determination of phospholipid levels and calcium (Ca) in the exhaled breath condensate was performed in dynamics - during the period of clinical manifestations and remission. \u0000Results. The level of phospholipids in the exhaled breath condensate was the highest in patients of all groups at the stage of clinical manifestations compared with the period of remission, while its lowest level was noted in the control group. During the peak of the disease, the level of Ca in the exhaled breath condensate was significantly lower compared to the period of remission. The control group had the highest level. \u0000Conclusions. The exhaled breath condensate's high level of phospholipids in the first days of the disease confirms cell damage in the presence of inflammation. Additionally, the exhaled breath condensate's Ca level is lowest during this period, possibly indicating its involvement in cell damage","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"30 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.15587/2519-4798.2024.298563
T. Loskutova, A. Petulko, Yuliya Donskaya
The aim: to investigate and analyze clinical parameters, laboratory biomarkers of lipid metabolism and endothelial dysfunction gene polymorphisms in early-onset and late-onset preeclampsia and to identify potential risk factor(s) for the development of early-onset preeclampsia. Materials and methods: a prospective case-control study included 133 women in the second half of pregnancy, including 46 with early-onset (EOP) and 87 with late-onset preeclampsia (LOP) and 34 conditionally healthy pregnant women with an uncomplicated obstetric history and no risk factors for preeclampsia. Concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides in blood plasma were determined. Genetic polymorphisms of endothelial dysfunction (192 Q→R PON-1, 677 C→ T MTHFR) were studied using allele-specific polymerase chain reaction. Results: Early-onset preeclampsia is associated with an increased relative risk: preterm delivery by 2.08 times (95 % CI 1.48-2.93), operative delivery by 2.2 times (95 % CI 1.46-3.33), early operative delivery by 2.9 times (95 % CI 1.5-5.5), fetal distress during delivery by 3.78 times (95 % CI 1.2-11.9), a low score on the Apgar scale on the 1st minute, less than 6 points, by 2.59 times (95 % CI 1.84-3.66), on the 5th minute – 5.04 times (95 % CI 1.41-18.11), Grade III prematurity – 13.24 times (95 % CI 3.14-55.78) compared to women with late-onset preeclampsia. The study found that overweight was more often observed in patients with EOP (34.8 %) than in those with normal pregnancy (15.9 %) (p=0.02; OR=2.8; 95 % CI 1.03-7.7), obesity (BMI > 30 kg/m2) was more often recorded in those with LOP (33.33 %) than in the control group (3 (6.8 %)) (p=0.02; OR=6.8; 95 % CI 1.9-23.9). Patients in both groups with preeclampsia showed signs of dyslipidemia, but its significance in the development of early-onset or late-onset preeclampsia has not been separately proven. The study found that the number of carriers of MTHFR 677 TT in the group with EOP prevailed over the indicator of C group where there were no carriers of the pathological homozygote 677TT (p<0.05, OR= 20.73 95 % CI 1.16-371.28), and the T allele in the EOP group occurs 1.78 times more often than in the LOP group (p<0.05, OR=2.22; 95 % CI 1.26-3.88) and 2.43 times more often than in the C group (P<0.05, or= 3.15; 95 % CI 1.54-6.45). Conclusions: Factors of early onset of PE include pre-pregnancy, overweight, first pregnancy, a history of preeclampsia, and carrier of the 677T allele of the MTHFR gene
目的：调查和分析早发型和晚发型子痫前期的临床参数、脂质代谢的实验室生物标志物和内皮功能障碍基因多态性，并确定早发型子痫前期发生的潜在风险因素。材料和方法：该前瞻性病例对照研究纳入了 133 名怀孕后半期的妇女，包括 46 名早发型子痫前期（EOP）和 87 名晚发型子痫前期（LOP）患者，以及 34 名无产科并发症史且无子痫前期风险因素的条件健康孕妇。测定了血浆中总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯的浓度。使用等位基因特异性聚合酶链反应研究了内皮功能障碍的基因多态性（192 Q→R PON-1、677 C→T MTHFR）。结果显示早发子痫前期与相对风险增加有关：早产增加 2.08 倍（95 % CI 1.48-2.93），手术分娩增加 2.2 倍（95 % CI 1.46-3.33），早期手术分娩增加 2.9 倍（95 % CI 1.5-5.5），分娩时胎儿窘迫增加 3.78 倍（95 % CI 1.与晚发型子痫前期的产妇相比，第 1 分钟阿普加评分表得分低（低于 6 分）的产妇是后者的 2.59 倍（95 % CI 1.84-3.66），第 5 分钟的产妇是后者的 5.04 倍（95 % CI 1.41-18.11），III 级早产的产妇是后者的 13.24 倍（95 % CI 3.14-55.78）。研究发现，子痫前期患者（34.8%）的超重率高于正常妊娠患者（15.9%）（P=0.02；OR=2.8；95 % CI 1.03-7.7），子痫后期患者（33.33%）的肥胖率（BMI > 30 kg/m2）高于对照组（3（6.8%））（P=0.02；OR=6.8；95 % CI 1.9-23.9）。两组先兆子痫患者都有血脂异常的迹象，但血脂异常在早发或晚发先兆子痫发病中的重要性尚未得到单独证实。研究发现，在 EOP 组中，MTHFR 677 TT 的携带者数量超过了没有病理同型 677TT 携带者的 C 组指标（P<0.05，OR= 20.73 95 % CI 1.P<0.05，OR=2.22；95 % CI 1.26-3.88），是C组的2.43倍（P<0.05，or=3.15；95 % CI 1.54-6.45）。结论导致早发性子痫的因素包括孕前、超重、首次妊娠、子痫前期病史以及 MTHFR 基因 677T 等位基因携带者。
{"title":"Body mass index, lipid profile, and endothelial dysfunction gene polymorphism in women with early-onset and late-onset preeclampsia","authors":"T. Loskutova, A. Petulko, Yuliya Donskaya","doi":"10.15587/2519-4798.2024.298563","DOIUrl":"https://doi.org/10.15587/2519-4798.2024.298563","url":null,"abstract":"The aim: to investigate and analyze clinical parameters, laboratory biomarkers of lipid metabolism and endothelial dysfunction gene polymorphisms in early-onset and late-onset preeclampsia and to identify potential risk factor(s) for the development of early-onset preeclampsia. \u0000Materials and methods: a prospective case-control study included 133 women in the second half of pregnancy, including 46 with early-onset (EOP) and 87 with late-onset preeclampsia (LOP) and 34 conditionally healthy pregnant women with an uncomplicated obstetric history and no risk factors for preeclampsia. Concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides in blood plasma were determined. Genetic polymorphisms of endothelial dysfunction (192 Q→R PON-1, 677 C→ T MTHFR) were studied using allele-specific polymerase chain reaction. \u0000Results: Early-onset preeclampsia is associated with an increased relative risk: preterm delivery by 2.08 times (95 % CI 1.48-2.93), operative delivery by 2.2 times (95 % CI 1.46-3.33), early operative delivery by 2.9 times (95 % CI 1.5-5.5), fetal distress during delivery by 3.78 times (95 % CI 1.2-11.9), a low score on the Apgar scale on the 1st minute, less than 6 points, by 2.59 times (95 % CI 1.84-3.66), on the 5th minute – 5.04 times (95 % CI 1.41-18.11), Grade III prematurity – 13.24 times (95 % CI 3.14-55.78) compared to women with late-onset preeclampsia. The study found that overweight was more often observed in patients with EOP (34.8 %) than in those with normal pregnancy (15.9 %) (p=0.02; OR=2.8; 95 % CI 1.03-7.7), obesity (BMI > 30 kg/m2) was more often recorded in those with LOP (33.33 %) than in the control group (3 (6.8 %)) (p=0.02; OR=6.8; 95 % CI 1.9-23.9). Patients in both groups with preeclampsia showed signs of dyslipidemia, but its significance in the development of early-onset or late-onset preeclampsia has not been separately proven. The study found that the number of carriers of MTHFR 677 TT in the group with EOP prevailed over the indicator of C group where there were no carriers of the pathological homozygote 677TT (p<0.05, OR= 20.73 95 % CI 1.16-371.28), and the T allele in the EOP group occurs 1.78 times more often than in the LOP group (p<0.05, OR=2.22; 95 % CI 1.26-3.88) and 2.43 times more often than in the C group (P<0.05, or= 3.15; 95 % CI 1.54-6.45). \u0000Conclusions: Factors of early onset of PE include pre-pregnancy, overweight, first pregnancy, a history of preeclampsia, and carrier of the 677T allele of the MTHFR gene","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"5 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.15587/2519-4798.2024.296672
Oleksandra Kozyra, Mykhailo G. Medvediev
The aim: to study of the prognostic value of endometrial receptivity and preimplantation genetic diagnosis of embryos, and their influence on the effectiveness of in vitro fertilization (IVF) programs. We also evaluate the importance of this factor in comparison with other potential causes of infertility. Materials and methods: This prospective cohort study included 123 infertile women who underwent in vitro fertilization (IVF) treatment. 93 patients had repeated unsuccessful implantation attempts and were divided into three groups: group 1 - patients who were treated using genetically untested embryos according to a standard fixed stimulation protocol, group 2 - patients who were treated using euploid embryos after preimplantation genetic screening according to standard fixed protocol; group 3 - patients who underwent treatment using euploid embryos after pre-implantation genetic screening and determination of the implantation window with subsequent modification of the stimulation protocol, according to the endometrial examination result. 30 patients had a first attempt at IVF, which was carried out using genetically untested embryos, according to a standard fixed protocol, and made up the control group (CG). Determination of the window of implantation was carried out by triple aspiration biopsy of the endometrium during the luteal phase of the menstrual cycle since the endometrium is most susceptible to implantation during this period. Samples were analyzed using scanning electron microscopy. Based on the results obtained, the endometrial preparation protocol was individualized for the next attempt. preimplantation genetic testing (PGT) of embryos was carried out by the next generation (NGS) method. Statistical analysis was performed using IBM SPSS V25.0 for Windows software. Results: According to the obtained results, patient characteristics, screening rates, IVF cycle characteristics, and the number, quality, and stage of transferred embryos were compared between groups. The rate of clinical pregnancy was 46.7 % among patients of group 1.70 % among patients of group 2, 82.8 % among patients of group 3 and 50.0 % of the control group and statistically significantly different between groups (χ2=10.955, p= 0.012). The rate of live birth was 43.3 % among patients of group 1, 53.3 % among patients of group 2, 72.4 % among patients of group 3 and 43.3 % - of the control group, however, it did not differ statistically significantly between groups (χ2=6,639, р=0,084) Conclusions: The unique window of implantation and the embryonic factor are among the main reasons for multiple failed implantation attempts. Personalization of the endometrial preparation protocol and preimplantation embryo diagnosis are effective methods to improve IVF outcomes
{"title":"Assessment of the implantation window and embryonic factor impact to the treatment of recurrent implantation failure (RIF). A prospective study","authors":"Oleksandra Kozyra, Mykhailo G. Medvediev","doi":"10.15587/2519-4798.2024.296672","DOIUrl":"https://doi.org/10.15587/2519-4798.2024.296672","url":null,"abstract":"The aim: to study of the prognostic value of endometrial receptivity and preimplantation genetic diagnosis of embryos, and their influence on the effectiveness of in vitro fertilization (IVF) programs. We also evaluate the importance of this factor in comparison with other potential causes of infertility.\u0000Materials and methods: This prospective cohort study included 123 infertile women who underwent in vitro fertilization (IVF) treatment. 93 patients had repeated unsuccessful implantation attempts and were divided into three groups: group 1 - patients who were treated using genetically untested embryos according to a standard fixed stimulation protocol, group 2 - patients who were treated using euploid embryos after preimplantation genetic screening according to standard fixed protocol; group 3 - patients who underwent treatment using euploid embryos after pre-implantation genetic screening and determination of the implantation window with subsequent modification of the stimulation protocol, according to the endometrial examination result. 30 patients had a first attempt at IVF, which was carried out using genetically untested embryos, according to a standard fixed protocol, and made up the control group (CG).\u0000Determination of the window of implantation was carried out by triple aspiration biopsy of the endometrium during the luteal phase of the menstrual cycle since the endometrium is most susceptible to implantation during this period. Samples were analyzed using scanning electron microscopy. Based on the results obtained, the endometrial preparation protocol was individualized for the next attempt. preimplantation genetic testing (PGT) of embryos was carried out by the next generation (NGS) method.\u0000Statistical analysis was performed using IBM SPSS V25.0 for Windows software.\u0000Results: According to the obtained results, patient characteristics, screening rates, IVF cycle characteristics, and the number, quality, and stage of transferred embryos were compared between groups. The rate of clinical pregnancy was 46.7 % among patients of group 1.70 % among patients of group 2, 82.8 % among patients of group 3 and 50.0 % of the control group and statistically significantly different between groups (χ2=10.955, p= 0.012). The rate of live birth was 43.3 % among patients of group 1, 53.3 % among patients of group 2, 72.4 % among patients of group 3 and 43.3 % - of the control group, however, it did not differ statistically significantly between groups (χ2=6,639, р=0,084)\u0000Conclusions: The unique window of implantation and the embryonic factor are among the main reasons for multiple failed implantation attempts. Personalization of the endometrial preparation protocol and preimplantation embryo diagnosis are effective methods to improve IVF outcomes","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"30 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.283806
T. Priyadarshini, Kokku Pradheep Kumar, S. Ch, Ravula Chaitanya Jyothi
Seizure disorders are a major public health problem in a developing country like India. Epilepsy characterized by recurrent unprovoked seizures is a common heterogeneous neurological problem in children that exerts a significant medical, physical, psychological, social, and economic challenge. This study evaluated the importance of the available diagnostic modalities, EEG and MRI, which could influence the management, prognosis and recurrence of unprovoked seizures. The aims and objectives: To determine the role of Electroencephalography and MRI BRAIN in evaluating children presenting with unprovoked seizures. Methodology: The present study was a hospital-based observational study carried out during the period of January 2021 to December 2021 of 70 children who presented with unprovoked seizures to the Department of Paediatrics, Niloufer Hospital, Hyderabad. Results: Among the 70 children who were investigated, EEG showed abnormal findings in 45 (64.29 %) cases. Out of these, the majority of 32 (45.71 %) cases had generalized seizures, and 13 (18.57 %) cases were focal seizures. MRI showed abnormal findings in 30 (42.86 %) cases, and an equal percentage of cases, 15 (21.43 %) of generalized seizures and focal seizures, were having abnormal MRI findings out of the 30 cases with abnormal MRI findings. But, when studied among the individual seizure subtype, a major proportion of focal seizure (68.18 %) cases out of 22 focal seizures had abnormal MRI findings when compared to 31.25 % of generalized seizure cases out of 48 generalized seizure cases with abnormal MRI findings. Conclusion: MRI can identify most of the structural brain abnormalities, and EEG is useful to clearly identify the region of the epileptogenic foci. Therefore, EEG and MRI were useful in identifying a possible cause for unprovoked seizures in children
{"title":"Role of EEG and MRI brain in the diagnosis of unprovoked seizures in children in a tertiary care centre","authors":"T. Priyadarshini, Kokku Pradheep Kumar, S. Ch, Ravula Chaitanya Jyothi","doi":"10.15587/2519-4798.2023.283806","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.283806","url":null,"abstract":"Seizure disorders are a major public health problem in a developing country like India. Epilepsy characterized by recurrent unprovoked seizures is a common heterogeneous neurological problem in children that exerts a significant medical, physical, psychological, social, and economic challenge. This study evaluated the importance of the available diagnostic modalities, EEG and MRI, which could influence the management, prognosis and recurrence of unprovoked seizures. \u0000The aims and objectives: To determine the role of Electroencephalography and MRI BRAIN in evaluating children presenting with unprovoked seizures. \u0000Methodology: The present study was a hospital-based observational study carried out during the period of January 2021 to December 2021 of 70 children who presented with unprovoked seizures to the Department of Paediatrics, Niloufer Hospital, Hyderabad. \u0000Results: Among the 70 children who were investigated, EEG showed abnormal findings in 45 (64.29 %) cases. Out of these, the majority of 32 (45.71 %) cases had generalized seizures, and 13 (18.57 %) cases were focal seizures. MRI showed abnormal findings in 30 (42.86 %) cases, and an equal percentage of cases, 15 (21.43 %) of generalized seizures and focal seizures, were having abnormal MRI findings out of the 30 cases with abnormal MRI findings. But, when studied among the individual seizure subtype, a major proportion of focal seizure (68.18 %) cases out of 22 focal seizures had abnormal MRI findings when compared to 31.25 % of generalized seizure cases out of 48 generalized seizure cases with abnormal MRI findings. \u0000Conclusion: MRI can identify most of the structural brain abnormalities, and EEG is useful to clearly identify the region of the epileptogenic foci. Therefore, EEG and MRI were useful in identifying a possible cause for unprovoked seizures in children","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91345830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.278978
N. Moyseyenko
Випадки синусогенних пошкоджень зорового нерву складно піддаються статистичній обробці в силу різноманітності проявів в початковий період та відмінностей перебігу, що не дає можливості своєчасно встановити діагноз, а також стандартизувати лікування. Мета дослідження полягала у вивченні ознак атрофії зорового нерву, спричиненої вторинними невритами, що поєднані з синуситами за допомогою оптико-когерентної томографії (ОКТ). Методи дослідження. В амбулаторних умовах, на базі Івано-Франківського національного медичного університету обстежено 8 пацієнтів (16 очей) віком 18-32 роки, які звернулися на консультацію у зв’язку із прогресуючою атрофією зорового нерву спричиненою вторинним невритом, поєднаною з синуситами. Проведено візометрію, офтальмоскопію і аналіз даних комп’ютерної периметрії та ОКТ. Результат. Дослідження 8 пацієнтів, із атрофією зорового нерву викликаною вторинним невритом поєднаним із синуситами, за даними ОКТ, показали пошкодження зорового нерву, які у ранній термін (до півроку) з моменту появи симптомів, характеризувались появою на стороні ураження в шару нервових волокон (ШНВ) білих секторів, які в подальшому поєднувались із червоно-жовтими, що може бути свідченням набряково-дегенеративних процесів. В більш пізній термін (понад рік) на цій стороні виявлялись жовто-червоні сектори та на протилежній – білі. Знайдене характеризує розвиток атрофії зорового нерву та залучення протилежної сторони. Висновок. Для покращення діагностики атрофії зорового нерву, викликаної вторинними невритами поєднаними із синуситами, використання параметрів ОКТ допоможе отримати більш повну картину стану зорового нерву та визначити оптимальний план лікування.
{"title":"Secondary sinusogenic neuritis and optic nerve atrophy","authors":"N. Moyseyenko","doi":"10.15587/2519-4798.2023.278978","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.278978","url":null,"abstract":"Випадки синусогенних пошкоджень зорового нерву складно піддаються статистичній обробці в силу різноманітності проявів в початковий період та відмінностей перебігу, що не дає можливості своєчасно встановити діагноз, а також стандартизувати лікування. \u0000Мета дослідження полягала у вивченні ознак атрофії зорового нерву, спричиненої вторинними невритами, що поєднані з синуситами за допомогою оптико-когерентної томографії (ОКТ). \u0000Методи дослідження. В амбулаторних умовах, на базі Івано-Франківського національного медичного університету обстежено 8 пацієнтів (16 очей) віком 18-32 роки, які звернулися на консультацію у зв’язку із прогресуючою атрофією зорового нерву спричиненою вторинним невритом, поєднаною з синуситами. Проведено візометрію, офтальмоскопію і аналіз даних комп’ютерної периметрії та ОКТ. \u0000Результат. Дослідження 8 пацієнтів, із атрофією зорового нерву викликаною вторинним невритом поєднаним із синуситами, за даними ОКТ, показали пошкодження зорового нерву, які у ранній термін (до півроку) з моменту появи симптомів, характеризувались появою на стороні ураження в шару нервових волокон (ШНВ) білих секторів, які в подальшому поєднувались із червоно-жовтими, що може бути свідченням набряково-дегенеративних процесів. \u0000В більш пізній термін (понад рік) на цій стороні виявлялись жовто-червоні сектори та на протилежній – білі. Знайдене характеризує розвиток атрофії зорового нерву та залучення протилежної сторони. \u0000Висновок. Для покращення діагностики атрофії зорового нерву, викликаної вторинними невритами поєднаними із синуситами, використання параметрів ОКТ допоможе отримати більш повну картину стану зорового нерву та визначити оптимальний план лікування.","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87600859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.281739
Hryhorii Garyuk, N. Bychkova
The aim of the research. Comparative study of the effectiveness of various methods of stopping epistaxis in patients under antithrombotic therapy. Materials and methods. The study of the effectiveness of various methods of stopping bleeding in 156 patients with epistaxis, which developed against the background of antithrombotic therapy, was conducted. All patients were divided into two groups: the main group (104 patients), in which the stoppage of nosebleeds was carried out by a combined method, which includes the use of a two-chamber hydrotampon of our own design in combination with "Nosochem" gel and thermal exposure, and a control group (52 patients), where classic gauze tamponade of the nasal cavity was used. Results. The method proposed by us showed its effectiveness in stopping nosebleeds in 100 (96.1 %) patients of the main group. In the control group of patients with gauze tamponade of the nasal cavity, tamponade ensured stable hemostasis in 44 (84.6 %) patients. Conclusions. The combined method of stopping epistaxis, which includes the use of a two-chamber hydrotampon of our own design in combination with "Nosochem" gel and thermal exposure, is more effective and safer compared to traditional gauze tamponade and can be recommended as the method of choice for stopping epistaxis against the background of antithrombotic therapy. The proposed method is easy to use, provides a reliable hemostatic effect, preserves the function of nasal breathing, reduces the trauma of tamponade and the risk of recurrent bleeding. One of the advantages of the hydrotampon is the absence of the tampon sticking to the mucous membrane and its impregnation with blood and wound exudate, which allows you to extend the period of tamponade if necessary, and the tampon removal procedure is less painful with a lower risk of bleeding recurrence
{"title":"Improvement of the methods of stopping nose bleeds in patients under antithrombotic therapy","authors":"Hryhorii Garyuk, N. Bychkova","doi":"10.15587/2519-4798.2023.281739","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.281739","url":null,"abstract":"The aim of the research. Comparative study of the effectiveness of various methods of stopping epistaxis in patients under antithrombotic therapy. \u0000Materials and methods. The study of the effectiveness of various methods of stopping bleeding in 156 patients with epistaxis, which developed against the background of antithrombotic therapy, was conducted. All patients were divided into two groups: the main group (104 patients), in which the stoppage of nosebleeds was carried out by a combined method, which includes the use of a two-chamber hydrotampon of our own design in combination with \"Nosochem\" gel and thermal exposure, and a control group (52 patients), where classic gauze tamponade of the nasal cavity was used. \u0000Results. The method proposed by us showed its effectiveness in stopping nosebleeds in 100 (96.1 %) patients of the main group. In the control group of patients with gauze tamponade of the nasal cavity, tamponade ensured stable hemostasis in 44 (84.6 %) patients. \u0000Conclusions. The combined method of stopping epistaxis, which includes the use of a two-chamber hydrotampon of our own design in combination with \"Nosochem\" gel and thermal exposure, is more effective and safer compared to traditional gauze tamponade and can be recommended as the method of choice for stopping epistaxis against the background of antithrombotic therapy. The proposed method is easy to use, provides a reliable hemostatic effect, preserves the function of nasal breathing, reduces the trauma of tamponade and the risk of recurrent bleeding. One of the advantages of the hydrotampon is the absence of the tampon sticking to the mucous membrane and its impregnation with blood and wound exudate, which allows you to extend the period of tamponade if necessary, and the tampon removal procedure is less painful with a lower risk of bleeding recurrence","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84485781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.281268
Beenish Mushtaq, Yasmeen Jan, A. A. Bhat, Farah Deeba
COVID-19 infection is a potentially traumatic experience in terms of the risk of running a Severe Acute Respiratory Syndrome in addition to the social implications of the disease in terms of being isolated and follow up of strict quarantine measures of close contact. The purpose of this study was to assess the prevalence of psychological distress and its risk factors in patients who develop COVID-19 infection. There is scanty evidence regarding the magnitude of COVID-19-related psychological distress (PD) among the general population of India, and Post Traumatic Stress Disorder (PTSD) is a Mental Disorder that develops after a traumatic event that has a life-threatening impact. The aim of this study was to assess COVID-19 infection. Material and methods: This study was conducted among 672 COVID-19 survivors of district Budgam from (March to August 2020). They were contacted by telephone, and psychological distress in the post-COVID recovery period was assessed using the IES-R scale. This is a 22-item scale, and each item is rated on a scale ranging from 0-4. Suitable Statistical Analysis was done to analyze risk factors for the development of any psychological distress. Methods: Descriptive cross-sectional study. Study design: Cross-sectional study from District Budgam of Kashmir Division. Study tool: using the IES-R scale for PTSD. Result: In our study prevalence of psychological distress using IES –R was mild in (7.08 %) of the study participants and moderate in (1.06 %) of the study participants. Psychological distress in study participants was examined by age, sex, employment status, family history, COVID-19 disease status and history of hospitalization. No statistical significance between age, gender, days of hospitalization and PTSD was seen. However, statistical significance with the IES–R score was seen between family history and the presence and absence of symptoms in the study subjects. Conclusion: As the pandemic crisis seems to be ebbing, the current findings help us to identify risk factors and devise pragmatic strategies to curtail the burden of mental issues and successfully meet the challenges that follow the pandemic
{"title":"A community-based cross-sectional study of COVID-19 and psychological distress using the impact of event scale revised among recovered patients of COVID-19","authors":"Beenish Mushtaq, Yasmeen Jan, A. A. Bhat, Farah Deeba","doi":"10.15587/2519-4798.2023.281268","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.281268","url":null,"abstract":"COVID-19 infection is a potentially traumatic experience in terms of the risk of running a Severe Acute Respiratory Syndrome in addition to the social implications of the disease in terms of being isolated and follow up of strict quarantine measures of close contact. The purpose of this study was to assess the prevalence of psychological distress and its risk factors in patients who develop COVID-19 infection. There is scanty evidence regarding the magnitude of COVID-19-related psychological distress (PD) among the general population of India, and Post Traumatic Stress Disorder (PTSD) is a Mental Disorder that develops after a traumatic event that has a life-threatening impact. \u0000The aim of this study was to assess COVID-19 infection. \u0000Material and methods: This study was conducted among 672 COVID-19 survivors of district Budgam from (March to August 2020). They were contacted by telephone, and psychological distress in the post-COVID recovery period was assessed using the IES-R scale. This is a 22-item scale, and each item is rated on a scale ranging from 0-4. Suitable Statistical Analysis was done to analyze risk factors for the development of any psychological distress. \u0000Methods: Descriptive cross-sectional study. \u0000Study design: Cross-sectional study from District Budgam of Kashmir Division. \u0000Study tool: using the IES-R scale for PTSD. \u0000Result: In our study prevalence of psychological distress using IES –R was mild in (7.08 %) of the study participants and moderate in (1.06 %) of the study participants. Psychological distress in study participants was examined by age, sex, employment status, family history, COVID-19 disease status and history of hospitalization. No statistical significance between age, gender, days of hospitalization and PTSD was seen. However, statistical significance with the IES–R score was seen between family history and the presence and absence of symptoms in the study subjects. \u0000Conclusion: As the pandemic crisis seems to be ebbing, the current findings help us to identify risk factors and devise pragmatic strategies to curtail the burden of mental issues and successfully meet the challenges that follow the pandemic","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87983624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.283687
O. Khomych, Y. Marushko
Early diagnosing pneumonia caused by the SARS-CoV-2 virus is an urgent problem today. The diagnosis of pneumonia caused by the SARS-CoV-2 virus is difficult, which is why it is promising to use acoustic monitoring to speed up the diagnosis and start of therapy. Aim: to determine the features of acoustic diagnostics of children with pneumonia caused by the SARS-CoV-2 virus using the "Trembita-Corona" acoustic monitoring device to correct and supplement traditional diagnostic methods. That is why respiratory acoustics is currently a promising scientific direction. We, pediatric specialists from Ukraine and leading specialists of the National Aviation University (Ukraine), have developed an experimental sample of the "Trembita-Corona" acoustic monitoring device. This device is used to diagnose breathing sounds. A patent protects the main constructive technical solutions of this device. Methods. We studied 230 patients aged 1 month to 18 years. The children were divided into 3 groups: 1 group – 100 patients with САР (the PCR test for the determination of the SARS-CoV-2 virus is negative), 2 group -100 healthy children(the PCR test for the determination of the SARS-CoV-2 virus is negative), 3 group - 30 children with pneumonia caused by the SARS-CoV-2 virus the PCR test for the determination of the SARS-CoV-2 virus is positive). The study complied with the international principles of GCP, GLP for clinical research. The protocol was approved at the meeting of the Commission on Bioethical Expertise at the National Medical University, named after O.O. Bogomolets. Mathematical processing was performed on specialized software developed in the Python language in the Google Codelabs environment. Further statistical processing of the obtained results was performed in specialized programs Medstart, EZR (R-Statistics) and "Matlab". Results. We use the "Trembita-Corona" acoustic monitoring device to analyze sounds at different octaves. In each of the 11 octaves using the "Trembita-Corona" acoustic monitoring device, we investigated the following indicators: the average signal power, frequency of the acoustic signal and amplitude. Using the аcoustic monitoring device "Trembita-Corona", were found differences between children with САP and healthy ones in average signal power in 0,1,2,3,4,5,6 octaves, in the frequency of the acoustic signal in 0 and 5 octaves, and in the amplitude of the acoustic signal in 0,2,3,4,5,6 octaves. Differences between children with САP and children with pneumonia caused by the SARS-CoV-2 virus in terms of average signal power in 0,1,2,3,4,5,6,7,9 octaves, frequency of the acoustic signal in 0 and 5 octaves, and amplitude of the acoustic signal in 0,1,4,5,6 octaves were also analyzed. Differences in average signal power and amplitude of the acoustic signal between pneumonia caused by the SARS-CoV-2 virus and healthy children were determined in the 2nd octave (p<0.01). Also, differences between these groups were found in the amplitu
{"title":"Evaluation of acoustic signal features in children with community-acquired pneumonia and pneumonia caused by the SARS-CoV-2 virus using the new acoustic monitoring device \"Trembita-Corona\"","authors":"O. Khomych, Y. Marushko","doi":"10.15587/2519-4798.2023.283687","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.283687","url":null,"abstract":"Early diagnosing pneumonia caused by the SARS-CoV-2 virus is an urgent problem today. The diagnosis of pneumonia caused by the SARS-CoV-2 virus is difficult, which is why it is promising to use acoustic monitoring to speed up the diagnosis and start of therapy. \u0000Aim: to determine the features of acoustic diagnostics of children with pneumonia caused by the SARS-CoV-2 virus using the \"Trembita-Corona\" acoustic monitoring device to correct and supplement traditional diagnostic methods. That is why respiratory acoustics is currently a promising scientific direction. We, pediatric specialists from Ukraine and leading specialists of the National Aviation University (Ukraine), have developed an experimental sample of the \"Trembita-Corona\" acoustic monitoring device. This device is used to diagnose breathing sounds. A patent protects the main constructive technical solutions of this device. \u0000Methods. We studied 230 patients aged 1 month to 18 years. The children were divided into 3 groups: 1 group – 100 patients with САР (the PCR test for the determination of the SARS-CoV-2 virus is negative), 2 group -100 healthy children(the PCR test for the determination of the SARS-CoV-2 virus is negative), 3 group - 30 children with pneumonia caused by the SARS-CoV-2 virus the PCR test for the determination of the SARS-CoV-2 virus is positive). \u0000The study complied with the international principles of GCP, GLP for clinical research. The protocol was approved at the meeting of the Commission on Bioethical Expertise at the National Medical University, named after O.O. Bogomolets. Mathematical processing was performed on specialized software developed in the Python language in the Google Codelabs environment. Further statistical processing of the obtained results was performed in specialized programs Medstart, EZR (R-Statistics) and \"Matlab\". \u0000Results. We use the \"Trembita-Corona\" acoustic monitoring device to analyze sounds at different octaves. In each of the 11 octaves using the \"Trembita-Corona\" acoustic monitoring device, we investigated the following indicators: the average signal power, frequency of the acoustic signal and amplitude. \u0000Using the аcoustic monitoring device \"Trembita-Corona\", were found differences between children with САP and healthy ones in average signal power in 0,1,2,3,4,5,6 octaves, in the frequency of the acoustic signal in 0 and 5 octaves, and in the amplitude of the acoustic signal in 0,2,3,4,5,6 octaves. Differences between children with САP and children with pneumonia caused by the SARS-CoV-2 virus in terms of average signal power in 0,1,2,3,4,5,6,7,9 octaves, frequency of the acoustic signal in 0 and 5 octaves, and amplitude of the acoustic signal in 0,1,4,5,6 octaves were also analyzed. \u0000Differences in average signal power and amplitude of the acoustic signal between pneumonia caused by the SARS-CoV-2 virus and healthy children were determined in the 2nd octave (p<0.01). Also, differences between these groups were found in the amplitu","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88257185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.15587/2519-4798.2023.281226
E. Satvaldieva, G. Ashurova, F. Kurbanov
The aim. This review provides a meta-analysis of current guidelines on nutrition in critically ill patients, including SCCM–ASPEN (2017), SSC (2012, 2021), ESPNIC (2020), and SSC (2020) pediatric sepsis guidelines. While the ESPNIC (2020) guidance complements the existing ASPEN (2017) guidelines for critical paediatrics, the Children's SSC (2020) did not find sufficient direct evidence to develop strong nutritional recommendations for children with sepsis/septic shock. Materials and methods. Looking for publications on nutritional assessment and nutritional support in children with sepsis have been keywords sepsis in children, nutrition, and critical conditions. Literature searched and analyzed from PubMed, Google Scholar and ScienceDirect databases. Revealed under-a sufficient amount of work on pediatric sepsis (an exception is neonatal sepsis), there are no protocols for assessing nutritional status and its correction in children diagnosed with sepsis/SS. Results. Despite ongoing research in this area, many questions remain unresolved and require systematic study. While some small and large pediatric studies have recommended nutritional therapy, the heterogeneity of children's ICUs in terms of age, pathology, disease severity, comorbidities, and nutritional status precludes a one-size-fits-all approach to nutrition in critically ill children. Therefore, an individualized approach to nutrition is necessary, considering the patient's unique circumstances and the risk/benefit ratio of different nutritional therapies. Conclusions. An extensive literature review did not reveal strong nutritional recommendations for children with sepsis/SS, underscoring the need for future research on the assessment and correction of protein-energy malnutrition in this population. Overall, this review highlights the importance of tailoring nutritional therapy to the individual needs of critically ill children with sepsis/ septic shock to optimize outcomes
{"title":"Nutritional therapy in children with sepsis and septic shock: unresolved questions and the need for an individualized approach","authors":"E. Satvaldieva, G. Ashurova, F. Kurbanov","doi":"10.15587/2519-4798.2023.281226","DOIUrl":"https://doi.org/10.15587/2519-4798.2023.281226","url":null,"abstract":"The aim. This review provides a meta-analysis of current guidelines on nutrition in critically ill patients, including SCCM–ASPEN (2017), SSC (2012, 2021), ESPNIC (2020), and SSC (2020) pediatric sepsis guidelines. While the ESPNIC (2020) guidance complements the existing ASPEN (2017) guidelines for critical paediatrics, the Children's SSC (2020) did not find sufficient direct evidence to develop strong nutritional recommendations for children with sepsis/septic shock. \u0000Materials and methods. Looking for publications on nutritional assessment and nutritional support in children with sepsis have been keywords sepsis in children, nutrition, and critical conditions. Literature searched and analyzed from PubMed, Google Scholar and ScienceDirect databases. Revealed under-a sufficient amount of work on pediatric sepsis (an exception is neonatal sepsis), there are no protocols for assessing nutritional status and its correction in children diagnosed with sepsis/SS. \u0000Results. Despite ongoing research in this area, many questions remain unresolved and require systematic study. While some small and large pediatric studies have recommended nutritional therapy, the heterogeneity of children's ICUs in terms of age, pathology, disease severity, comorbidities, and nutritional status precludes a one-size-fits-all approach to nutrition in critically ill children. Therefore, an individualized approach to nutrition is necessary, considering the patient's unique circumstances and the risk/benefit ratio of different nutritional therapies. \u0000Conclusions. An extensive literature review did not reveal strong nutritional recommendations for children with sepsis/SS, underscoring the need for future research on the assessment and correction of protein-energy malnutrition in this population. Overall, this review highlights the importance of tailoring nutritional therapy to the individual needs of critically ill children with sepsis/ septic shock to optimize outcomes","PeriodicalId":21672,"journal":{"name":"ScienceRise: Medical Science","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86977257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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