Synthetic Approach to Diversified Imidazo[2,1-b][1,3]thiazines and Its Evaluation as Non-Steroidal Anti-Inflammatory Agents †

Abstract

: The present work is devoted to the synthesis of imidazo[2,1- b ][1,3]thiazine derivatives as possible anti-inflammatory agents. The synthetic approach to (2-pyridinyloxy)substituted imid-azo[2,1- b ][1,3]thiazines based on the interaction of the polysubstituted 2-chloropyridines with 3-hydroxy-imidazo[2,1- b ][1,3]thiazines was proposed. Selective nucleophilic substitution in position 2 of pyridine ring was observed in the mentioned reaction. The synthesized (2-pyridinyloxy)substi-tuted imidazo[2,1- b ][1,3]thiazines drug-like properties were studied in silico using SwissADME and anti-inflammatory activity in carrageenan test in vivo. Hit-compounds with satisfactory drug-like and pharmacological features were identified as promising objects for futhercoming structure opti-mization and in-depth studies.