Dietary interventions for autism spectrum disorder: An updated systematic review of human studies.

Q3 Medicine Psychiatrike = Psychiatriki Pub Date : 2022-04-27 DOI:10.22365/jpsych.2022.073
C. N. Amadi, C. Orish, C. Frazzoli, O. Orisakwe
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引用次数: 6

Abstract

Autism is a complex spectrum of disorders with genetic, epigenetic, autoimmune, oxidative stress, and environmental etiologies. Treatment of ASD using dietary approach is a promising strategy, especially owing to its safety and availability. Our study critically analysed the roles and efficacy of antioxidants, probiotics, prebiotics, camel milk and vitamin D. This systematic review provides an updated synopsis of human studies that investigated therapeutic benefits of these dietary interventions in autism. A total of 943 papers were identified out of which 21 articles were included in the systematic review. The selected studies investigated the impact of 5 different dietary supplementations in ASD symptom and behaviours. These agents include; antioxidants/polyphenolic compounds, probiotics, prebiotics, camel milk and vitamin D. From the results of the present review, antioxidants/polyphenolic compounds decreased the levels of inflammatory cytokines and improved behavioural symptoms. Probiotics improved behavioural and GI symptoms as well as restored gut microbiota equilibrium. Prebiotics decreased levels of inflammatory cytokines, improved behavioural and GI symptoms and improved gut microbiota. Vitamin D improved behavioural symptoms and offered protective effects against neurotoxicity. Camel milk reduced inflammatory responses and oxidative stress. Given the chronic nature as well as early onset of ASD, dietary supplements become useful to complement nutritional deficiencies in children with ASD. Key benefits of these agents stem from their ability to target multiple physiological areas via the gut brain-axis and are devoid of potential harmful or aggravating effects on ASD patients. The evidence collated in this review propose that dietary intervention may provide a new platform for the management of autism.
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自闭症谱系障碍的饮食干预:人类研究的最新系统综述。
自闭症是一种复杂的疾病谱系,具有遗传、表观遗传、自身免疫、氧化应激和环境病因。使用饮食方法治疗ASD是一种很有前途的策略,特别是由于它的安全性和可用性。我们的研究批判性地分析了抗氧化剂、益生菌、益生元、骆驼奶和维生素d的作用和功效。这一系统综述提供了研究这些饮食干预对自闭症治疗效果的人类研究的最新摘要。共筛选到943篇论文,其中21篇纳入系统评价。选定的研究调查了5种不同的膳食补充剂对ASD症状和行为的影响。这些代理包括;抗氧化剂/多酚化合物、益生菌、益生元、骆驼奶和维生素d。从本综述的结果来看,抗氧化剂/多酚化合物降低了炎症细胞因子的水平,改善了行为症状。益生菌改善行为和胃肠道症状,并恢复肠道菌群平衡。益生元降低了炎症细胞因子水平,改善了行为和胃肠道症状,改善了肠道微生物群。维生素D改善了行为症状,并对神经毒性有保护作用。骆驼奶可以减少炎症反应和氧化应激。考虑到自闭症谱系障碍的慢性和早发性,膳食补充剂对于补充自闭症谱系障碍儿童的营养不足是有用的。这些药物的主要好处在于它们能够通过肠道-脑轴靶向多个生理区域,并且对ASD患者没有潜在的有害或加重作用。本综述整理的证据表明,饮食干预可能为自闭症的管理提供一个新的平台。
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来源期刊
Psychiatrike = Psychiatriki
Psychiatrike = Psychiatriki Medicine-Medicine (all)
CiteScore
2.60
自引率
0.00%
发文量
37
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