The role of the complement system in dermatological disease

F. Ali, F. Al‐Niaimi
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引用次数: 1

Abstract

Complement bridges the innate and adaptive immune systems, recognizing and eliminating microorganisms and maintaining tissue homeostasis. Perturbations in the complement cascade can be of profound clinical consequence, with dermatological associations including impaired control of infectious agents, predisposition to autoimmune disease (notably systemic lupus erythematosus) and hereditary and acquired angioedema. In this review, the authors describe the fundamentals of the complement cascade and discuss the clinical manifestations of defects in signaling in order to contextualize the rational testing of complement components and functional assays in dermatological practice.
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补体系统在皮肤病中的作用
补体连接先天免疫系统和适应性免疫系统,识别和消除微生物,维持组织稳态。补体级联的扰动可能具有深远的临床后果,与皮肤病学相关的包括感染性病原体控制受损、自身免疫性疾病(特别是系统性红斑狼疮)易感性、遗传性和获得性血管性水肿。在这篇综述中,作者描述了补体级联的基本原理,并讨论了信号缺陷的临床表现,以便在皮肤病学实践中合理检测补体成分和功能分析。
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