Evaluation of Momordica charantia, Boerhaavia diffusa and Cotreatment on Streptozotocin induced Diabetes in Male Wistar Rats

Abstract

The aim of this study is to evaluate the co-administration of aqueous leaf extracts of Momordica charantia and Boerhaavia diffusa on Streptozotocin induced Diabetes in Male Wistar Rats. A total of 36 male wistar rats between the weights of 100-120g were divided into six (6) groups (n=6), five (5) groups received I.P. Streptozotocin (60mg/kg) and the remaining group served as the normal control. Rats body weights, blood sugar levels, glucose 6 phosphate dehydrogenase, key liver enzymes, enzymatic antioxidant and liver tissue histology were examined using standard procedures and the results demonstrated that, administration of leaf extract of M.charantia, B.diffusa and particularly co-administration of M.charantia+B.diffusa significantly p<0.05 aided weight reduction, lowered blood sugar levels, enhanced the levels of liver enzymes and antioxidant parameters. Thus, M.charantia and B.diffusa are excellent therapeutic candidates for the management of diabetes mellitus and its related complication.