A comprehensive and flexible approach to the automated-dissolution testing of pharmaceutical drug products incorporating direct UV–vis fiber-optic analysis, on-line fluorescence analysis, and off-line storage options

Laboratory Robotics and Automation Pub Date : 2000-02-25 DOI:10.1002/(SICI)1098-2728(2000)12:1<12::AID-LRA3>3.0.CO;2-F

P. Rogers, P. A. Hailey, G. A. Johnson, V. A. Dight, C. Read, A. Shingler, P. Savage, T. Roche, J. Mondry

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引用次数: 8

Abstract

An automated system for on-line determination of the dissolution rates of drug-delivery formulations to USP Methods I and II is described. The system employs UV–vis spectroscopy utilizing either a fiber-optic probe for direct determination or the option of on-line flow through analysis with prior filtration. The system is also capable of on-line flow through analysis utilizing both UV–vis and fluorescence detection and an off-line storage option for further sample processing. The system also comprises a complete IT solution including a simple user interface, data archival to an NT server, remote client server interrogation of the database, and automatic report generation. © 2000 John Wiley & Sons, Inc. Lab Robotics and Automation 12:12–22, 2000

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一种全面灵活的药物产品自动溶出测试方法，包括直接紫外-可见光纤分析、在线荧光分析和离线存储选项

描述了一种用于在线测定美国药典方法I和II的给药制剂溶出率的自动化系统。该系统采用紫外可见光谱，利用光纤探头直接测定，或选择在线流动，通过预先过滤的分析。该系统还能够利用紫外-可见和荧光检测进行在线流动分析，并提供离线存储选项，以便进一步处理样品。该系统还包括一个完整的IT解决方案，包括一个简单的用户界面、到NT服务器的数据存档、远程客户机服务器查询数据库和自动生成报告。©2000 John Wiley &儿子,Inc。实验室机器人与自动化，2000

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Laboratory Robotics and Automation

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