Excellent Response of Infantile Hemangioma with Oral Propranolol: A Case Report

Armyta Denissafitri, Riezky Januar Pramitha, Yuri Widia, I. Citrashanty, I. Zulkarnain, S. Sawitri
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Abstract

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy. Most IHs resolve spontaneously and do not require treatment. Therapeutic intervention is necessary for life-threatening IH, tumors posing functional risks, ulceration, and severe anatomic distortion, especially on the face. Beta-blockers, most specifically propranolol, have been shown to induce involution of IH, which should be administered as early as possible to avoid potential complications. Purpose: To report a case of IH with visual impairment treated successfully using oral propranolol. Case: A 4-month-old girl weighing, 6.3 kg, with redness plaques on the right face since 3 weeks after birth. The lesions rapidly increased in size within 2 months, and the lesions on her right eyelid made it difficult to open her right eye. Dermatological examination showed erythematous plaques, compressible and varying in size and ptosis. The patient was diagnosed with periocular infantile hemangioma and was given oral propranolol therapy with an initiated dose 3x1 mg. The dose was increased gradually. The lesions were significantly decreased and she could open her right eye normally after 5 months of propranolol therapy. Discussion: Some cases of IH require early treatment. Early treatment is indicated for IH causing functional impairment. The use of propranolol in the management of IH is very effective in the reduction of the lesions and Has minimal side effects. Conclusion: Early diagnosis and intervention with propranolol for IH play an important role in determining the optimal outcomes.
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口服心得安治疗婴幼儿血管瘤疗效显著1例
背景:婴幼儿血管瘤是婴幼儿最常见的良性肿瘤。大多数IHs自行消退,不需要治疗。治疗干预对于危及生命的IH、构成功能风险的肿瘤、溃疡和严重的解剖扭曲(特别是面部)是必要的。β受体阻滞剂,特别是心得安,已被证明可诱发IH复发,应尽早给予,以避免潜在的并发症。目的:报告1例IH伴视力障碍患者口服心得安治疗成功。病例:4个月大的女婴,体重6.3公斤,出生后3周右侧面部出现红斑。病变在2个月内迅速增大,右眼睑病变使右眼难以睁眼。皮肤检查显示红斑斑块,可压缩,大小不一,上睑下垂。诊断为婴幼儿眼周血管瘤,给予口服心得安,起始剂量3x1 mg。剂量逐渐增加。经5个月普萘洛尔治疗,病变明显减少,右眼可正常睁眼。讨论:一些IH病例需要早期治疗。早期治疗是指IH引起的功能损害。在IH治疗中使用心得安是非常有效的,在减少病变和最小的副作用。结论:早期诊断和普萘洛尔干预对IH的预后至关重要。
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