A Study of Comparative Efficacy of Local and Foreign Antibiotic Discs used in Southeast Nigeria

Abstract

The aim of this study is to evaluate the most effective antibiotic disc on three chosen bacteria organisms. There are Staphylococcus aureus, Salmonella gallinarium and Esherichia coli. Three antibiotic discs made of one foreign produced from Oxoid, Bakingsloke, U.K and two locally produced antibiotic disc from Optun laboratories and Unique laboratories both in Nigeria of the twelve different antibiotics used, only six was of particularly important for the purpose of this study. These are gentamycin (10ug), ceftriazone (30ug), ampicillin (10ug) pericillin (10ug), Kanamycin (30ug), and amoxicillin (10ug). Antibiotic disc of same Mean Inhibitory Concentration (MIC) was used for the three types. The study showed that the antibiotic disc produced from foreign and local companies are effective, however, the foreign has an edge in being more sensitive. The zones of inhibition for antibiotic disc from Oxoid possess greater and clearer inhibition zones in mm/ diameter for Staphylococcus aureus , Salmonella gallinarium and E . coli : The mean zone of inhibition of various antibiotics against these three bacteria showed that there is a statistical significance (p< 0.05) between the product from Oxoid and the two others.