{"title":"Chemical constituents from Glechoma longituba","authors":"Qu Haibin","doi":"10.4268/cjcmm20140428","DOIUrl":null,"url":null,"abstract":"Objective To study the chemical constituents from Glechoma longituba and their anti-oxidant activity in vitro.Methods The chemical constituents were isolated and purified by solvent extraction,repeated silica gel column chromatography,and reverse phase preparative HPLC.Their structures were identified on the basis of ESI-MS and NMR spectra.The anti-oxidant activities of these compounds were screened by DPPH free radical scavenging assay in vitro.Results Ten compounds were isolated and elucidated as cosmosiin(1),dihydrocaffeic acid(2),caffeic acid(3),isololiolide(4),vomifoliol(5),glecholone(6),apigenin(7),aurantiamide(8),(+)-lariciresinol(9),and()-syringaresinol(10).Conclusion Compounds 2,4,and 8—10 are isolated from the plants in Glechoma L.for the first time;Compounds 9 and 10 are lignans firstly obtained from this plant.DPPH free radical scavenging assays show that compounds 2,3,9,and 10 exhibit potential anti-oxidant activity.","PeriodicalId":10295,"journal":{"name":"中草药杂志","volume":"20 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中草药杂志","FirstCategoryId":"1095","ListUrlMain":"https://doi.org/10.4268/cjcmm20140428","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Objective To study the chemical constituents from Glechoma longituba and their anti-oxidant activity in vitro.Methods The chemical constituents were isolated and purified by solvent extraction,repeated silica gel column chromatography,and reverse phase preparative HPLC.Their structures were identified on the basis of ESI-MS and NMR spectra.The anti-oxidant activities of these compounds were screened by DPPH free radical scavenging assay in vitro.Results Ten compounds were isolated and elucidated as cosmosiin(1),dihydrocaffeic acid(2),caffeic acid(3),isololiolide(4),vomifoliol(5),glecholone(6),apigenin(7),aurantiamide(8),(+)-lariciresinol(9),and()-syringaresinol(10).Conclusion Compounds 2,4,and 8—10 are isolated from the plants in Glechoma L.for the first time;Compounds 9 and 10 are lignans firstly obtained from this plant.DPPH free radical scavenging assays show that compounds 2,3,9,and 10 exhibit potential anti-oxidant activity.
中草药杂志Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
1.10
自引率
0.00%
发文量
23538
期刊介绍：
hinese Traditional and Herbal Drugs, a monthly journal with “zhongcaoyao” as Chinese name, the initial issue was distributed in January, 1970 and its ISSN is 0253-2670. The journal is an academic and technical journal sponsored by Chinese Pharmaceutical Association and Tianjin Institute of Pharmaceutical Research (TIPR). The journal, which has a long history of 41 years, offers the columns of research papers, brief reports, reviews, dissertation, and special treatises to report the recent achievements of our basic study, production, quality control, and clinic application on traditional Chinese medicine and Chinese materia medica. The editorial committee consists of over one hundred of specialists with a great academic attainment in pharmaceutical research, education, production, quality control, and clinic application.
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