Preface/Front Matter

O. Pourquié
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Abstract

Our understanding of skeletal biology has taken tremendous strides during the past few years. On the one hand, the spectacular recent breakthroughs in developmental biology have led to an understanding of the global rules shaping and positioning the cartilage and bone primordia in the vertebrate embryo. On the other hand, the discovery of key master regulators of the chondrocyte and bone lineage, such as Sox9 and Runx2, as well as the signaling pathways involved in the regulation of the differentiation of these lineages, has provided a much better understanding of these processes. This knowledge led to the elucidation of the molecular etiology of a majority of bone and cartilage genetic diseases. The goal of this book is to provide a comprehensive and up-to-date summary of the field of skeletal biology. This is a large field and due to space limitations, some areas might be covered more extensively than others. However, an attempt was made to cover all stages of skeletal development and patterning, as well as differentiation of cartilage and bone cells. The complex area of bone physiology is discussed in some of the chapters, but is not addressed extensively. This book covers essentially three major themes. The first theme relates to the development and patterning of bone in vertebrates. Several chapters deal with classical model systems that have been used to study bone and cartilage patterning in the vertebrate embryo. Specifically, the limb bud and the rules governing the formation of bone primordia are addressed, as well as the
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前言/前页
在过去的几年里,我们对骨骼生物学的理解取得了巨大的进步。一方面,最近在发育生物学方面取得的重大突破使我们了解了脊椎动物胚胎中软骨和骨原基形成和定位的整体规则。另一方面,发现软骨细胞和骨谱系的关键主调控因子,如Sox9和Runx2,以及参与这些谱系分化调控的信号通路,为这些过程提供了更好的理解。这一知识导致了大多数骨和软骨遗传疾病的分子病因学的阐明。这本书的目标是提供一个全面的和最新的骨骼生物学领域的总结。这是一个很大的领域,由于篇幅限制,有些领域可能比其他领域涵盖得更广泛。然而,试图涵盖骨骼发育和模式的所有阶段,以及软骨和骨细胞的分化。在一些章节中讨论了骨生理学的复杂领域,但没有广泛地解决。这本书主要包括三个主题。第一个主题与脊椎动物骨骼的发育和模式有关。几章处理经典模型系统,已用于研究骨和软骨模式在脊椎动物胚胎。具体地说,肢芽和控制骨原基形成的规则被处理,以及
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