The current state and potential direction of cannabis research

Fabián Hernández, Sathees B. C. Chandra
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引用次数: 1

Abstract

Abstract Cannabis sativa has long been linked as a medicinal treatment to many conditions such as cancer, epilepsy, bone fracture healing, anti-inflammatory response, neuro-degenerative disorders such as multiple sclerosis (MS), and rheumatoid arthritis. This article discusses the underlying conditions that are significantly controlled or modulated by cannabis. The primary components that have been isolated from cannabis are the psychoactive cannabinoid Δ (9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). Both cannabinoids bind directly to endocannabinoid receptors that are located abundantly in the nervous system and visceral organs. Cannabis has also been used as a treatment to manage pain for chemotherapy patients and induce hunger in HIV (Human Immunodeficiency Virus) positive patients. Cannabis has received vast amounts of attention because of its effect on treating epilepsy. Although the biochemical pathway for this is not yet known, the current evidence in favor of this treatment has opened the door for further research. Finally, the cannabis terpenoids that have been isolated from cannabis sativa are discussed as a future focal point for cannabis research. This review article sets to provide the medical community with a broad synopsis of recent research trials on Cannabis sativa that have indicated its medicinal benefits. The removal of the Public Health Service (PHS) Review, which has inhibited government funding and access to research samples, is an imperative step for obtaining further knowledge into the biochemical pathways and effects of medical cannabis.
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大麻研究的现状和潜在方向
长期以来,大麻一直被认为是一种治疗多种疾病的药物,如癌症、癫痫、骨折愈合、抗炎反应、多发性硬化症(MS)等神经退行性疾病和类风湿性关节炎。本文讨论了大麻显著控制或调节的潜在条件。从大麻中分离出来的主要成分是精神活性大麻素Δ(9)-四氢大麻酚(THC)和大麻二酚(CBD)。这两种大麻素都直接与内源性大麻素受体结合,内源性大麻素受体大量存在于神经系统和内脏器官中。大麻还被用来治疗化疗患者的疼痛,并诱导艾滋病毒(人类免疫缺陷病毒)阳性患者的饥饿。大麻因其治疗癫痫的效果而受到广泛关注。虽然其生化途径尚不清楚,但目前支持这种治疗的证据为进一步研究打开了大门。最后,讨论了从大麻中分离出的大麻萜类化合物作为未来大麻研究的重点。这篇评论文章旨在为医学界提供最近对大麻的研究试验的广泛概述,这些试验表明大麻具有药用价值。取消公共卫生服务审查是进一步了解医用大麻的生化途径和影响的必要步骤,因为它限制了政府的资助和获得研究样本。
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