Low Antimullerian Hormone Levels Improve Fertility Outcome in Patients with Polycystic Ovary Syndrome

Abstract

Background: It was known that polycystic ovary syndrome (PCOS) patients have high AMH levels. The aim of this study is to show whether low AMH levels are associated with better clinical pregnancy rates in patients with PCOS. Methods: This retrospective study was performed on 443 patients with PCOS referred to BAU MedicalparkGoztepe Hospital IVF Clinic from January 2015 to October 2020. Participants ranged in age from 18 to 40, had their first two IVF trials, had performed frozen-thawed embryo transfer (FET) cycle at day 5. The diagnosis of PCOS was made using the Rotterdam criteria. Data related to patients' AMH were compared with each other, and based on the value, participants were divided into two groups: the first group was AMH≥7 (N = 49); The second group was AMH <7 (N = 394). Results: The pregnancy test was positive for 288 (65%) participants. Of these participants, 214 had livebirth, 71 had miscarriages, and 3 had stillbirths. There was no significant difference in age and BMI between the two groups. There were no significant differences between the two groups in the number of stimulation days, the total number of oocytes, and MII oocytes. The numbers of frozen embryos were higher in the AMH≥7 group (p = 0.005). The positive pregnancy results were significantly higher in the AMH<7 group than in the AMH≥ 7 group (P= 0.02). There was no significant difference in live birth, stillbirth, and miscarriage rates between the two groups. Conclusion: Low levels of circulating AMH are associated with better clinical pregnancy rates in patients with PCOS.