Wan Norizzati Wan Mohamad Zamri, N. M. Z. Mat Zin, N. A. Mohd Nawi, Aziati Aswari Anuar, Nazihah Mohd Yunus, S. Sulong, Z. Alwi, R. Ankathil
Sex chromosome aneuploidies are the most common chromosome abnormalities associated with infertility in adult men. 47, XYY syndrome also known as Jacob Syndrome (JS) is one sex chromosome aneuploidy. Majority of 47, XYY men show normal spermatogenesis while minority may have varying degrees of impairment in spermatogenesis. This case report discusses about a 32 year old Malay gentleman who was diagnosed to have azoospermia for which cytogenetic analysis revealed an abnormal mosaic 47,XYY/45,X karyotype pattern as the underlying genetic cause. Abnormal mosaic 47,XYY/45,X karyotype associated with infertility is extremely rare in human population and hence reported for its rarity.
{"title":"Mosaic 47,XYY/45,X Presenting With Male Infertility: A Rare Case Report","authors":"Wan Norizzati Wan Mohamad Zamri, N. M. Z. Mat Zin, N. A. Mohd Nawi, Aziati Aswari Anuar, Nazihah Mohd Yunus, S. Sulong, Z. Alwi, R. Ankathil","doi":"10.33425/2639-9342.1171","DOIUrl":"https://doi.org/10.33425/2639-9342.1171","url":null,"abstract":"Sex chromosome aneuploidies are the most common chromosome abnormalities associated with infertility in adult men. 47, XYY syndrome also known as Jacob Syndrome (JS) is one sex chromosome aneuploidy. Majority of 47, XYY men show normal spermatogenesis while minority may have varying degrees of impairment in spermatogenesis. This case report discusses about a 32 year old Malay gentleman who was diagnosed to have azoospermia for which cytogenetic analysis revealed an abnormal mosaic 47,XYY/45,X karyotype pattern as the underlying genetic cause. Abnormal mosaic 47,XYY/45,X karyotype associated with infertility is extremely rare in human population and hence reported for its rarity.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"224 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77498029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Basu Jayasri, O. Sara, Wu Yingyi, Encalada M Diana, Molina Lara, Mikhail Magdy
Introduction: In human placenta, two different branching patterns of chorionic blood vessels exist. In the dispersal type, the chorionic blood vessels undergo successive divisions with gradually diminishing caliber as the blood vessels traverse towards the placental margins. In the magistral type, the blood vessels traverse without appreciable decrease in diameter. We hypothesize, that matrix-degrading enzymes secreted by cytotrophoblasts may influence the branching patterns of these chorionic blood vessels. We, therefore, determined if placental expression of matrix metalloproteinase-9 (MMP-9) protein differed between the two vascular patterns of chorionic blood vessels of human placenta. Methods: 26 full-term delivered placentas were collected from normotensive women. Chorionic villi (CV) were isolated. CV MMP-9 protein was analyzed using human MMP-9 monoclonal antibody based ELISA kits. A novel method was used to determine the vascular patterns of the placentas from placental photographs. Independent t test was used for statistical analysis. P< 0.05 was considered significant. Results: The branching pattern of the chorionic blood vessels was 54% dispersal and 46% of the magistral types. In placentas with dispersal type of branching pattern, MMP-9 protein expression was significantly higher (p=0.035). Women who delivered placentas with magistral type of branching pattern, the mean newborn weight was found to be significantly higher (p=0.039). Conclusion: The study introduces a novel method to investigate chorionic vascular network of human placenta. Our findings underscore the importance of CV MMP-9 protein in affecting the placental branching architecture of chorionic blood vessels in humans. In the magistral type, the calibers of the chorionic blood vessels from the point of insertion of the umbilical cord to the placental margins remained more or less unchanged. We suggest, that this unchanged caliber of blood vessels in the magistral type, may have allowed better nourishment and oxygen to be catered to the fetus; resulting in fetal weight gain.
{"title":"Influence of Placental Metalloproteinase-9 Protein on the Branching Architecture of Chorionic Blood Vessels of Human Placenta","authors":"Basu Jayasri, O. Sara, Wu Yingyi, Encalada M Diana, Molina Lara, Mikhail Magdy","doi":"10.33425/2639-9342.1169","DOIUrl":"https://doi.org/10.33425/2639-9342.1169","url":null,"abstract":"Introduction: In human placenta, two different branching patterns of chorionic blood vessels exist. In the dispersal type, the chorionic blood vessels undergo successive divisions with gradually diminishing caliber as the blood vessels traverse towards the placental margins. In the magistral type, the blood vessels traverse without appreciable decrease in diameter. We hypothesize, that matrix-degrading enzymes secreted by cytotrophoblasts may influence the branching patterns of these chorionic blood vessels. We, therefore, determined if placental expression of matrix metalloproteinase-9 (MMP-9) protein differed between the two vascular patterns of chorionic blood vessels of human placenta. Methods: 26 full-term delivered placentas were collected from normotensive women. Chorionic villi (CV) were isolated. CV MMP-9 protein was analyzed using human MMP-9 monoclonal antibody based ELISA kits. A novel method was used to determine the vascular patterns of the placentas from placental photographs. Independent t test was used for statistical analysis. P< 0.05 was considered significant. Results: The branching pattern of the chorionic blood vessels was 54% dispersal and 46% of the magistral types. In placentas with dispersal type of branching pattern, MMP-9 protein expression was significantly higher (p=0.035). Women who delivered placentas with magistral type of branching pattern, the mean newborn weight was found to be significantly higher (p=0.039). Conclusion: The study introduces a novel method to investigate chorionic vascular network of human placenta. Our findings underscore the importance of CV MMP-9 protein in affecting the placental branching architecture of chorionic blood vessels in humans. In the magistral type, the calibers of the chorionic blood vessels from the point of insertion of the umbilical cord to the placental margins remained more or less unchanged. We suggest, that this unchanged caliber of blood vessels in the magistral type, may have allowed better nourishment and oxygen to be catered to the fetus; resulting in fetal weight gain.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80131193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uterine fibroid is the most common pelvic tumour in women of reproductive age. It has an incidence of 0.05 – 5%. Its prevalence peaks between 30 – 39 years. It is seven times (7x) more common among blacks than Caucasians [1]. Here, we present a 30-year-old primigarvid woman who had caesarean myomectomy in which 42 number of variously sized fibroid masses were enucleated in a private specialist hospital. This case report suggests that caesarean myomectomy does not appear to increase the risk of immediate or short term post-partum morbidity. It also shows that it is feasible to remove all the visible and palpable fibroid nodules during caesarean myomectomy with relative safety.
{"title":"Successful Removal of Forty- Two Number Fibroid Masses during Caesarean Section in A Primigravid Woman in a Private Facility in a Low Resource Area: A Case Report","authors":"Mbamara Su, Ajoku S C","doi":"10.33425/2639-9342.1167","DOIUrl":"https://doi.org/10.33425/2639-9342.1167","url":null,"abstract":"Uterine fibroid is the most common pelvic tumour in women of reproductive age. It has an incidence of 0.05 – 5%. Its prevalence peaks between 30 – 39 years. It is seven times (7x) more common among blacks than Caucasians [1]. Here, we present a 30-year-old primigarvid woman who had caesarean myomectomy in which 42 number of variously sized fibroid masses were enucleated in a private specialist hospital. This case report suggests that caesarean myomectomy does not appear to increase the risk of immediate or short term post-partum morbidity. It also shows that it is feasible to remove all the visible and palpable fibroid nodules during caesarean myomectomy with relative safety.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86626830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Farid, A. Chamsi, M. Swaraldahab, Hassan Swaraldahab
Background: Benign ovarian tumours are a very common clinically encountered condition and rarely become malignant. The outcome is generally good, varying from asymptomatic big cysts to symptomatic ones with different sizes. Objective: To know the demography of patients, the types of cyst, presentation and management options. Thereafter, comparison of data with other national and international studies was done. Results: This retrospective cohort study was carried out in Security Forces Hospital, Riyadh in Saudi Arabia between January 1st, 2015 to January 31st, 2018. There were 67 cases of histologically diagnosed benign ovarian neoplasms in that period. The age range of 20-49 made up 72.1% of cases and a mean of 37 years, with a BMI of 20-36.9 Kg/m². 67.2% of cases were electively admitted and 88% of cases had ovarian cyst more than 5cm in size. The affected side was almost similar being 35.8% on right side and 32.8% on the left, 28.3% were bilateral and 2.99% were paraovarian cysts. 31.3% of patients were single and 10.4% multiparous. A parity of up to 6 constituted 41.8% of cases, 58.2% were managed by laparotomy and 41.8% had laparoscopic approach. 56.7% of cases were of epithelial origin, 17.9% functional cyst and 16.4% were Germ cell tumours. Sex cord variety were seen in 5.96% of cases and a combination of epithelial and stromal components made up 2.98% of cases. During the 2-D ultrasound studies done for all patients, 10.4% did not have concomitant Doppler studies done. Of those that had doppler, 8.9% were abnormal. Blood group O positive was seen in 52.2% of cases and 23.9% were ‘A’ rhesus positive and 11.94% were ‘B’ rhesus positive. 4.48% of cases were pregnant at the time of diagnosis. 13.4% had recurrence of cyst, abdominal pain was the main presentation in 59.7% of cases, palpable mass in 4.48%, 22.4% had previous Cesarean Section. Conclusion: To determine the incidence of histologically diagnosed types of benign ovarian neoplasm in a Tertiary hospital in Central part of Saudi Arabia and compare it with other regional areas, in same country, neighboring countries and international figures.Suggestions on certain aspects that were made includes improvements, and that could possibly be a future recommendation, on diagnosis and prognosis of ovarian neoplasm, such as different combinations of tumour markers (CA125 + HE4), surgical management, recurrence rate and blood groups.
{"title":"The Demographic Characteristics of Patients with Benign Ovarian Cyst and Histological Pattern in a Tertiary Center in Riyadh, Saudi Arabia","authors":"G. Farid, A. Chamsi, M. Swaraldahab, Hassan Swaraldahab","doi":"10.33425/2639-9342.1168","DOIUrl":"https://doi.org/10.33425/2639-9342.1168","url":null,"abstract":"Background: Benign ovarian tumours are a very common clinically encountered condition and rarely become malignant. The outcome is generally good, varying from asymptomatic big cysts to symptomatic ones with different sizes. Objective: To know the demography of patients, the types of cyst, presentation and management options. Thereafter, comparison of data with other national and international studies was done. Results: This retrospective cohort study was carried out in Security Forces Hospital, Riyadh in Saudi Arabia between January 1st, 2015 to January 31st, 2018. There were 67 cases of histologically diagnosed benign ovarian neoplasms in that period. The age range of 20-49 made up 72.1% of cases and a mean of 37 years, with a BMI of 20-36.9 Kg/m². 67.2% of cases were electively admitted and 88% of cases had ovarian cyst more than 5cm in size. The affected side was almost similar being 35.8% on right side and 32.8% on the left, 28.3% were bilateral and 2.99% were paraovarian cysts. 31.3% of patients were single and 10.4% multiparous. A parity of up to 6 constituted 41.8% of cases, 58.2% were managed by laparotomy and 41.8% had laparoscopic approach. 56.7% of cases were of epithelial origin, 17.9% functional cyst and 16.4% were Germ cell tumours. Sex cord variety were seen in 5.96% of cases and a combination of epithelial and stromal components made up 2.98% of cases. During the 2-D ultrasound studies done for all patients, 10.4% did not have concomitant Doppler studies done. Of those that had doppler, 8.9% were abnormal. Blood group O positive was seen in 52.2% of cases and 23.9% were ‘A’ rhesus positive and 11.94% were ‘B’ rhesus positive. 4.48% of cases were pregnant at the time of diagnosis. 13.4% had recurrence of cyst, abdominal pain was the main presentation in 59.7% of cases, palpable mass in 4.48%, 22.4% had previous Cesarean Section. Conclusion: To determine the incidence of histologically diagnosed types of benign ovarian neoplasm in a Tertiary hospital in Central part of Saudi Arabia and compare it with other regional areas, in same country, neighboring countries and international figures.Suggestions on certain aspects that were made includes improvements, and that could possibly be a future recommendation, on diagnosis and prognosis of ovarian neoplasm, such as different combinations of tumour markers (CA125 + HE4), surgical management, recurrence rate and blood groups.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"171 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85420983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 43-year-old multigravida patient, 12 days postpartum and with a history of cholecystectomy, presented to our institution with markedly elevated blood pressure, nausea, vomiting, epigastric pain, and headache. She met the criteria for preeclampsia with severe features and was placed on magnesium sulfate. Further investigation was required when the laboratory values and abdominal pain were unresponsive to the medications. A magnetic resonance cholangiopancreatography was done and the patient was diagnosed with choledocholithiasis.
{"title":"Choledocholithiasis Masquerading as Preeclampsia with Severe Features in a Patient with a History of a Cholecystectomy Case Report","authors":"S. Nahidi, S. Dave, Brittany N Robles, Amr Shayeb","doi":"10.33425/2639-9342.1170","DOIUrl":"https://doi.org/10.33425/2639-9342.1170","url":null,"abstract":"A 43-year-old multigravida patient, 12 days postpartum and with a history of cholecystectomy, presented to our institution with markedly elevated blood pressure, nausea, vomiting, epigastric pain, and headache. She met the criteria for preeclampsia with severe features and was placed on magnesium sulfate. Further investigation was required when the laboratory values and abdominal pain were unresponsive to the medications. A magnetic resonance cholangiopancreatography was done and the patient was diagnosed with choledocholithiasis.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"204 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83665934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Shigeta, R. Asano, Yuka Oi, Kayo Katayama, Yumi Ishidera
Background: Uterine leiomyomas appear after menarche, typically grow during the reproductive years, and then stabilize or regress after menopause. However, there have been several reports of a considerable number of patients who have undergone surgery for uterine leiomyomas during the postmenopausal period. In this paper, we discuss two issues: the possible reasons for the growth of uterine leiomyomas and the differential diagnoses of presumed leiomyomas in postmenopausal women. Methods: PubMed was searched for studies about uterine leiomyomas and sarcomas with a focus on postmenopausal women. Main findings: Several hypotheses exist for the growth of postmenopausal leiomyomas. Among these, we propose the following as an important candidate: estrogen and progesterone do not necessarily work in a positive way. In addition, in postmenopausal patients, the incidence of malignant tumors is very high, and it is generally difficult to diagnose uterine sarcoma prior to surgery. Conclusion: We propose that in cases in which uterine sarcomas cannot be ruled out, physicians should proactively consider surgery, particularly for postmenopausal patients.
{"title":"Uterine Leiomyoma in Postmenopausal Women: Possible Reasons for Growth and Differential Diagnosis","authors":"H. Shigeta, R. Asano, Yuka Oi, Kayo Katayama, Yumi Ishidera","doi":"10.33425/2639-9342.1173","DOIUrl":"https://doi.org/10.33425/2639-9342.1173","url":null,"abstract":"Background: Uterine leiomyomas appear after menarche, typically grow during the reproductive years, and then stabilize or regress after menopause. However, there have been several reports of a considerable number of patients who have undergone surgery for uterine leiomyomas during the postmenopausal period. In this paper, we discuss two issues: the possible reasons for the growth of uterine leiomyomas and the differential diagnoses of presumed leiomyomas in postmenopausal women. Methods: PubMed was searched for studies about uterine leiomyomas and sarcomas with a focus on postmenopausal women. Main findings: Several hypotheses exist for the growth of postmenopausal leiomyomas. Among these, we propose the following as an important candidate: estrogen and progesterone do not necessarily work in a positive way. In addition, in postmenopausal patients, the incidence of malignant tumors is very high, and it is generally difficult to diagnose uterine sarcoma prior to surgery. Conclusion: We propose that in cases in which uterine sarcomas cannot be ruled out, physicians should proactively consider surgery, particularly for postmenopausal patients.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83014718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatma S. Abad, B. Birch, B. V. van Rijn, B. Lwaleed
Background: Pre-eclampsia (P-EC) is a pregnancy-specific disorder, characterised by placental insufficiency and endothelial dysfunction. It is a significant cause of maternal and fetal morbidity. Women with a history of P-EC have heightened risks of future cardiovascular and thromboembolic disease. In addition, pre- clamptic patients have elevated levels of clotting and angiogenic factors; however it is unclear whether these changes persist postpartum. Aims: The aim of this study was to investigate the relationship between haemostatic as well as angiogenic and anti-angiogenic factors in women with a past-history of P-EC, including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), in combination with tissue factor (TF) and TF pathway inhibitor (TFPI), also whether these factors were altered postpartum in women with a history of P-EC. Methods: The study followed a case-control design. Blood samples were obtained at 6-12 months postpartum from 21 primiparous women after a pregnancy affected by P-EC, and 21 women with a previously unaffected pregnancy. Plasma concentrations of each of the factors were determined using enzyme-linked immunosorbent assay. Results: Significant differences were not observed in levels of VEGF (p=0.068), PlGF (p=0.333), sFlt-1 (p=0.910), sEng (p=0.612), TF (p=0.260) or TFPI (p=0.786) between women with and without a history of pre-eclampsia. Additionally, no significant difference was found in the TF: TFPI ratio between case and control groups (p=0.734). Conclusion: This study does not support the hypothesis that levels of VEGF, PlGF, sFlt-1, sEng, TF or TFPI are altered in women with a history of P-EC compared to controls. However, we observed a weak positive association between all parameters measured. While we acknowledge that this is a pilot study and that the sample sizes is relatively small, our results suggest that circulating haemostatic, angiogenic and anti-angiogenic factors are not significantly altered in women with a past-history of P-EC.
{"title":"Do Patients with A History of Pre-Eclampsia Have Elevated Levels of Coagulation and Angiogenic Markers Postpartum?","authors":"Fatma S. Abad, B. Birch, B. V. van Rijn, B. Lwaleed","doi":"10.33425/2639-9342.1163","DOIUrl":"https://doi.org/10.33425/2639-9342.1163","url":null,"abstract":"Background: Pre-eclampsia (P-EC) is a pregnancy-specific disorder, characterised by placental insufficiency and endothelial dysfunction. It is a significant cause of maternal and fetal morbidity. Women with a history of P-EC have heightened risks of future cardiovascular and thromboembolic disease. In addition, pre- clamptic patients have elevated levels of clotting and angiogenic factors; however it is unclear whether these changes persist postpartum. Aims: The aim of this study was to investigate the relationship between haemostatic as well as angiogenic and anti-angiogenic factors in women with a past-history of P-EC, including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), in combination with tissue factor (TF) and TF pathway inhibitor (TFPI), also whether these factors were altered postpartum in women with a history of P-EC. Methods: The study followed a case-control design. Blood samples were obtained at 6-12 months postpartum from 21 primiparous women after a pregnancy affected by P-EC, and 21 women with a previously unaffected pregnancy. Plasma concentrations of each of the factors were determined using enzyme-linked immunosorbent assay. Results: Significant differences were not observed in levels of VEGF (p=0.068), PlGF (p=0.333), sFlt-1 (p=0.910), sEng (p=0.612), TF (p=0.260) or TFPI (p=0.786) between women with and without a history of pre-eclampsia. Additionally, no significant difference was found in the TF: TFPI ratio between case and control groups (p=0.734). Conclusion: This study does not support the hypothesis that levels of VEGF, PlGF, sFlt-1, sEng, TF or TFPI are altered in women with a history of P-EC compared to controls. However, we observed a weak positive association between all parameters measured. While we acknowledge that this is a pilot study and that the sample sizes is relatively small, our results suggest that circulating haemostatic, angiogenic and anti-angiogenic factors are not significantly altered in women with a past-history of P-EC.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90215864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pancieri Bárbara Gobetti, Ozório Carla Nassur, Gomes Carolina Viana Bueno, Ribeiro Ana Paula Alves, Vasconcellos Vitor Fiorin, Musiello Rubens Bermudes, Chambô Filho Antönio
Background: A complete hydatidiform mole (CHM) coexistent with a live fetus is rare; however, in a triplet pregnancy it is even rarer. In such cases, diagnosis is complex and often delayed, since unlike cases of a hydatidiform mole alone, the coexisting CHM often fails to be detected at ultrasound, while Β-hCG, a marker of the disease, is already elevated because of the multiple pregnancy. The risk of maternal complications and of progression to malignant gestational trophoblastic disease is significantly greater in cases of a complete mole. Case: The case reported here refers to a triplet pregnancy consisting of two viable fetuses and a CHM. Conclusion: Outcome was favorable for the two live fetuses; however, the hydatidiform mole progressed to an invasive mole, requiring chemotherapy. Remission was achieved successfully.
{"title":"Triplet Pregnancy with a Complete Hydatidiform Mole and Two Live Fetuses: A Case Report","authors":"Pancieri Bárbara Gobetti, Ozório Carla Nassur, Gomes Carolina Viana Bueno, Ribeiro Ana Paula Alves, Vasconcellos Vitor Fiorin, Musiello Rubens Bermudes, Chambô Filho Antönio","doi":"10.33425/2639-9342.1166","DOIUrl":"https://doi.org/10.33425/2639-9342.1166","url":null,"abstract":"Background: A complete hydatidiform mole (CHM) coexistent with a live fetus is rare; however, in a triplet pregnancy it is even rarer. In such cases, diagnosis is complex and often delayed, since unlike cases of a hydatidiform mole alone, the coexisting CHM often fails to be detected at ultrasound, while Β-hCG, a marker of the disease, is already elevated because of the multiple pregnancy. The risk of maternal complications and of progression to malignant gestational trophoblastic disease is significantly greater in cases of a complete mole. Case: The case reported here refers to a triplet pregnancy consisting of two viable fetuses and a CHM. Conclusion: Outcome was favorable for the two live fetuses; however, the hydatidiform mole progressed to an invasive mole, requiring chemotherapy. Remission was achieved successfully.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84753233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Do, S. Nahidi, S. Dave, Sean Borden, D. Faustin
HELLP syndrome is part of the preeclampsia-eclampsia spectrum, and it typically presents after 20 weeks of gestation. In this case report, we review the hypotheses for the pathophysiology of HELLP and report one of the few cases of the syndrome presenting prior to 20 weeks of gestation.
{"title":"A Case of Fatal Maternal-Fetal Conflict: HELLP Syndrome Diagnosed in a Second Trimester Pregnancy","authors":"N. Do, S. Nahidi, S. Dave, Sean Borden, D. Faustin","doi":"10.33425/2639-9342.1165","DOIUrl":"https://doi.org/10.33425/2639-9342.1165","url":null,"abstract":"HELLP syndrome is part of the preeclampsia-eclampsia spectrum, and it typically presents after 20 weeks of gestation. In this case report, we review the hypotheses for the pathophysiology of HELLP and report one of the few cases of the syndrome presenting prior to 20 weeks of gestation.","PeriodicalId":12828,"journal":{"name":"Gynecology & reproductive health","volume":"255 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76166556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adekemi E. Olowokere RM, Ademidun O. Adedeji RM, Aanuoluwapo O. Olajubu RM, Mercy K. Aladegboye RM, Omolola O Irinoye RM
Background: Menopause has been associated with decline in sexual well-being among women. The quality of sexual interactions in heterosexual relationship are increasingly being considered as an important indicator of positive health and quality of life. Objectives: This article describes the sexual health status of menopausal women and the challenges preventing them from having a fulfilling sexual life. Method: This was an exploratory qualitative interview. Seventeen (17) menopausal women were interviewed individually and face-to-face using semi-structured interview guide. The interviews were analyzed using content and thematic analysis. Results: The analysis yielded two themes for sexual health status; (a) good sexual health status and (b) poor sexual health status. Majority of the study participants claimed to have poor sexual health status. The challenges to having a fulfilling sexual life yielded four themes; (a) fear (b) lack of sexual partner (c) ageing process and (c) being breadwinner of the family. Conclusion: The study concludes that majority of the women in the study have poor sexual health status and diverse challenges to having a fulfilling sexual life. This article offers a premise for healthcare providers to see the necessity to inquire about sexual health from post-reproductive age women and to provide necessary support that can help improve their sexual health.
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