OP23 Associations between lifetime hazardous drinking and associations between lifetime hazardous drinking and biomarkers of cardiometabolic health and liver function among older adults: findings from the whitehall II prospective cohort study

Abstract

Background Hazardous drinking among older adults is a growing concern, however there is limited research on the effect of chronic versus acute hazardous drinking among older people, and how the effects vary across life. This study among older adults, explores the association of positive AUDIT-C scores across life with objective biomarkers of cardio-metabolic health. Methods Analyses were undertaken among 4820 civil servants aged 59–83 years, within the prospective Whitehall II study, who answered the life-grid AUDIT-C inventory during the 2011–2012 survey and provided biological measurements (264 non-drinkers were excluded). Lifetime hazardous drinking groups were defined using a threshold of ≥5, at each decade of life from age 16 to 80+. These groups were as follows; never hazardous-drinker (reference), former hazardous-drinker1 (before age 50), former hazardous-drinker2 (after age 50), current hazardous-drinker (past hazardous-drinker sporadically), stable hazardous-drinker (hazardous-drinker in every decade). Similar groups were created for lifetime binge-drinking categories; never/former/current/stable binge-drinker (AUDIT-3 ≥2). Fully-adjusted linear regression was carried out on cardio-metabolic biomarkers including: waist circumference (WC, measured in cm), body mass index (BMI, kg/m2), total cholesterol (TC, mmol/L), systolic (SBP, mmHg) and diastolic (DBP, mmHg) blood pressure, gamma-glutamyl transferase (GGT), fatty-liver index scores (FLI) and lifetime hazardous/binge drinking as exposure, using STATA15. Covariates included sex, age, socio-economic position, ethnicity, smoking status, physical activity, BMI and fruit and vegetable consumption. Results Over half of the sample had been a hazardous-drinker at some point; Current hazardous-drinkers (21%), former hazardous-drinkers1 (

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老年人终生危险饮酒和终生危险饮酒与心脏代谢健康和肝功能生物标志物之间的关联:来自whitehall II前瞻性队列研究的发现

背景:老年人危险饮酒日益受到关注，然而，关于老年人慢性和急性危险饮酒的影响以及影响在一生中如何变化的研究有限。这项针对老年人的研究，探讨了终生审计- c阳性评分与心脏代谢健康的客观生物标志物之间的关系。方法对4820名年龄在59-83岁之间的公务员进行分析，这些人在2011-2012年调查期间回答了life-grid AUDIT-C清单并提供了生物学测量(264名不饮酒者被排除在外)。从16岁到80岁以上的每十年，使用≥5的阈值来定义终生危险饮酒组。这些群体如下:从未危险饮酒者(参考)，曾经危险饮酒者1(50岁以前)，曾经危险饮酒者2(50岁以后)，现在危险饮酒者(过去偶尔)，稳定的危险饮酒者(每十年一次)。对终身酗酒者也建立了类似的小组;从未/曾经/现在/稳定的酗酒者(AUDIT-3≥2)。使用STATA15对心脏代谢生物标志物进行全校正线性回归，包括:腰围(WC，以cm计)、体重指数(BMI, kg/m2)、总胆固醇(TC, mmol/L)、收缩压(SBP, mmHg)和舒张压(DBP, mmHg)、γ -谷氨酰转移酶(GGT)、脂肪肝指数评分(FLI)和终身危险/酗酒暴露。协变量包括性别、年龄、社会经济地位、种族、吸烟状况、身体活动、身体质量指数和水果和蔬菜消费。结果超过一半的样本在某些时候是危险饮酒者;目前危险饮酒者(21%)、曾经危险饮酒者1(< 50岁)(19%)、曾经危险饮酒者2(≥50岁)(11%)、稳定危险饮酒者(5%)。在调整协变量后，危险饮酒者的腰围比从不危险饮酒者大(前危险饮酒者1 (&bgr;=1.17 [95% CI 0.25, 2.08]);前危险饮酒者2(1.88[95%可信区间0.77,2.98]);当前危险饮酒者(2.44[1.55,3.34])和稳定危险饮酒者(3.85[2.23,5.47]))。BMI也与当前和频繁的危险饮酒有类似的线性关系。当前危险饮酒者的SBP(2.44[1.19, 3.68])、log(GGT)(22.64[18.27,27.02])和FLI评分(4.05[2.92,5.18])高于从不危险饮酒者，稳定的危险饮酒者(SBP(2.78[0.53, 5.04])、log(GGT)(17.94[10.12, 25.75])、FLI(3.76，[1.75, 5.77])也是如此。终生酗酒者与腰围、血压、GGT和FLI结果也有类似的关联。结论:危险饮酒在老年人中很常见，并可能增加心脏代谢危险因素，这可能与终生持续危险饮酒相结合。人口中危险饮酒的减少可能会对老年人产生立竿见影的改善，但如果在生命过程中进行早期干预，尤其是在体重增加方面，也会产生长期的改善。未来的分析将评估终生危险饮酒、心血管事件和死亡率的风险。

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