Pharmacotherapy and efficacy of antihypoxants and antioxidants

D. A. Pasenko
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Abstract

In clinical practice, antihypoxants, «deproteinized calf blood hemoderivatives », and an antioxidant, «ethylmethylhydroxypyridine succinate», are used in the treatment of cerebral ischemic stroke and transient attacks. The use of these drugs is pathophysiologically justified as it prevents neuronal damage, which is confirmed by the clinical guidelines «Ischemic Stroke and Transient Ischemic Attack in Adults», 2021. However, these drugs have not been proven effective. The purpose of the work: to study the expected effect of these drugs, based on pharmacodynamics and pharmacokinetics, as well as biochemical and physiological (pathophysiological) capabilities of the body.
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抗氧剂和抗氧化剂的药物治疗和疗效
在临床实践中,抗氧剂“去蛋白化小牛血液衍生物”和抗氧化剂“乙基甲基羟吡啶琥珀酸酯”被用于脑缺血和短暂性发作的治疗。这些药物的使用在病理生理学上是合理的,因为它可以防止神经元损伤,这一点得到了临床指南《成人缺血性卒中和短暂性缺血性发作》(2021)的证实。然而,这些药物尚未被证明有效。工作的目的:研究这些药物的预期效果,基于药效学和药代动力学,以及身体的生化和生理(病理生理)能力。
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