Pregnancy Outcomes in COVID-19 Vaccination During Pregnancy

Abstract

Objective: To evaluate the pregnancy outcomes in COVID-19 vaccination during pregnancy Materials and Methods: The present study was a retrospective cohort study. The data were collected from pregnant women attending antenatal care (ANC) and delivery at Makarak Hospital, Kanchanaburi Province, between September 2021 and April 2022. The studied subjects were categorized into three groups, antepartum factor, intrapartum factor, and postpartum and newborn factor. The relationship of each factor was brought for comparative study in COVID-19 vaccination status as vaccinated or unvaccinated, during pregnancy. Then, multivariable analysis was used to adjust the relationship of the variables in each group. Results: Five hundred sixteen pregnant women attended ANC and delivered. They were aged 27.5 years on the average. Most of them were gravida 2. The proportion of vaccines received was 19.2%. When comparing between the vaccinated and the unvaccinated groups, it was found that the vaccinated group was significantly increased in diabetes disorder (adjusted OR 3.54, 95% CI 1.67 to 7.50) and significantly decreased in neonatal intensive care unit (NICU) admission (adjusted OR 0.43, 95% CI 0.24 to 0.76). Other adverse outcomes between the two groups were not significantly different. In addition, COVID-19 infection rate during intrapartum period was not different (adjusted OR 2.13, 95% CI 0.87 to 5.22, p=0.09). Conclusion: Diabetes disorder during pregnancy was significantly higher and risk of NICU admission was significantly lower in the COVID-19 vaccinated group compared with the unvaccinated group. Adverse obstetric outcomes between the vaccinated and unvaccinated groups were not different. Keywords: Pregnancy outcomes; COVID-19 vaccination; Pregnant women