Synthesis of 4-amino-2arylamino-5-(3-arylsydnon-4-oyl) thiazoles.

Abstract

Marine natural products have attracted the attention of biologists and chemists the world over for the past five decades. As a result of the potential for new drug discovery, scientists from different disciplines, such as organic chemistry, bioorganic chemistry, pharmacology, biology and ecology have become interested in marine natural products. This interest has led to the discovery of almost 8,500 marine natural products to date and many of the compounds have shown very promising biological activity. The ocean is considered to be a great source of potential drugs. The chemical compounds, which are isolated from marine sources usually consists of nitrogen containing heterocyclic rings. Several sydnone derivatives show a broad range of physiological activities, including antimicrobial, anti-inflammatory, analgesic and antipyretic properties. Hence, chemists have been enthusiastically pursuing the synthesis of such derivatives.