Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.

Rosa M. Canet-Avilés, M. Anderton, N. Hooper, A. Turner, P. Vaughan
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毒蕈碱通过依赖于蛋白激酶C(α)、src-酪氨酸激酶和细胞外信号调节激酶而不是磷脂酶C的途径促进人神经母细胞瘤SH-SY5Y中可溶性淀粉样蛋白前体蛋白的分泌。
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In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs. Increased expression of mRNAs for microtubule disassembly molecules during nerve regeneration. Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease. PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells.
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