Nanoparticles reshape the biomedical industry

P. Hassanzadeh, F. Atyabi, R. Dinarvand
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引用次数: 1

Abstract

Over the last decades, increasing interest has been attracted towards the nanotechnology which provide a set of promising research tools and theranostic approaches. Tremendous research efforts in nanofabrication technology have led to the production of biocompatible nanostructures and advanced carriers with various configurations for protection of the loaded biomolecules or drugs against the metabolism or excretion. Furthermore, controlled delivery and targeted therapy may result in the improved therapeutic effects against a variety of diseases and reduced adverse effects of drugs. The efficiency of protein drugs may be negatively affected by their limited transportation within the body and short half-lives. Application of nanoparticles may significantly improve the pharmacological profiles of protein drugs. In neurology, high-resolution imaging techniques, nanoengineered materials capable of interaction with the nervous systems, and nanopharmaceuticals with minimal toxicity and improved bioavailability may be of great theranostic significance. This may provide remarkable breakthroughs in the pharmaceutical industry and health-care system. In the present review, the significance of nanotechnology and modeling approaches in health-care system has been highlighted.
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纳米粒子重塑了生物医学产业
在过去的几十年里,越来越多的兴趣被纳米技术所吸引,它提供了一套有前途的研究工具和治疗方法。在纳米制造技术方面的巨大研究努力导致了生物相容性纳米结构和各种构型的先进载体的生产,以保护负载的生物分子或药物免受代谢或排泄的影响。此外,控制给药和靶向治疗可以改善对多种疾病的治疗效果,减少药物的不良反应。蛋白质药物在体内的运输有限和半衰期短,可能会对其效率产生负面影响。纳米颗粒的应用可以显著改善蛋白质药物的药理学特征。在神经病学领域,高分辨率成像技术、能够与神经系统相互作用的纳米工程材料以及毒性最小、生物利用度更高的纳米药物可能具有重要的治疗意义。这可能会给制药工业和卫生保健系统带来显著的突破。在本综述中,强调了纳米技术和建模方法在卫生保健系统中的重要性。
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