Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats

C. Ekpenyong
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引用次数: 2

Abstract

Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratus decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratus decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats. Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): the control (group 1, G1), GV alone (G2), GV plus C. citratus decoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6). Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days. Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures. Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, Original Research Article Ekpenyong; BJPR, 15(6): 1-8, 2017; Article no.BJPR.32895 2 FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratus at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group. Conclusion: Thus, C. citratus decoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.
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香蒲煎剂对汽油蒸气致雌性大鼠生殖毒性的影响
目的:最近的研究表明,植物分子,特别是那些富含抗氧化、抗炎和免疫调节成分的植物分子,可以改变和防止汽油化合物对生殖终点的有害影响。然而,柑橘汤是否能缓解汽油蒸气(GV)诱导的女性生殖激素紊乱尚未见文献报道。本研究评价了柑桔汤对gv诱导的雌性大鼠生殖毒性的缓解作用。研究设计:将体重185±11.2 g的雌性Wistar白化大鼠72只分为6组,每组n = 12只:对照组(G1组)、GV单独治疗组(G2组)、GV加柠檬汤(500 mg/kg;G3), (1000mg /kg;G4), (1500mg /kg;G5)和GV加维生素C(200毫克/公斤;G6)。学习地点和时间:尼日利亚阿夸伊博姆州尤约大学生理学系。各组均治疗35 d。方法:血清中女性生殖激素黄体酮(P3)、雌二醇(E2)、黄体生成素(LH)、促卵泡激素(FSH)以及超氧化物歧化酶(SOD)和丙二醛(MDA)的水平;使用标准程序评估动物的氧化应激标志物。结果:GV显著(p < 0.05)降低血清P3、E2、LH水平;生物工程学报,15(6):1-8,2017;文章no.BJPR。与对照动物相比,FSH, SOD和血清MDA水平升高。然而,G3、G4和G5组动物同时服用不同剂量的柑橘,G6组动物同时服用维生素C, gv降低的生殖激素和抗氧化酶水平呈剂量依赖关系(p < 0.05), gv升高的氧化应激标志物水平下降至与对照组相似的水平。结论:枸橼水煎剂对gv诱导的生殖功能障碍和氧化应激具有改善作用。
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