Edema reducing potentials of some emerging Schiff’s bases of murrayanine

Abstract

Murrayanine is the most active and popular phytoconstituent present in the Indian curry plant, also known as Murraya koenigii L. (family: Rutaceae).1 Till date, the ethnopharmacological importance of the root, stem bark, and leaves are known successfully such as purgative, anthelminthic, febrifuge, carminative, astringent, and stomachic.2 In our previous research done so far, benzothiazepine,3 oxadiazole,4 3,4-methylenedioxy,5 thiazole,6 benzoxazepine,7 thiadiazole,8 isoxazole,9 hydantoin,10 phthalimide,11 pyrimidine,12 benzodiazepine,13 pyrazole,14 chalcone,15 and methylsulfone16 derivatives of murryanine have been rationally synthesized as hybrids in our laboratory, characterized comprehensively, and biologically screened in various animal models to explore their pharmacological potentials such as anti-convulsant, anti-inflammatory, anti-anxiety, anti-diabetic, anti-oxidant, anti-fungal, and anti-bacterial.