Association between ultrasonographic parameters, clinical and biochemical indicators and results of surveys in patients with heart failure with moderately reduced left ventricle fraction

Abstract

The aim: to evaluate the probable impact of type 2 diabetes on quality of life, clinical, biochemical and ultrasonographic parameters in patients with HFwmrLVEF and associations between them. Materials and methods: the study included 68 patients with HFwmrLVEF, including 36 patients with concomitant DM type 2 and 32 patients without type 2 DM, and 18 healthy individuals. All study participants underwent anthropometric (height, weight, BMI), laboratory (clinical blood test, biochemical blood test to determine ACT, ALT, creatinine, glucose, lipid spectrum, potassium, sodium and magnesium, ELISA to determine glycated hemoglobin and NT-proBN ), instrumental (EchoC, ECG) surveys and surveys to assess quality of life (EQ-5D-5L). Statistical processing of the obtained results was performed using the statistical software package SPSS v.19.0. Results: between the group of patients with HFwmrLVEF with concomitant type 2 DM and the group with HFwmrLVEF without type 2 DM according to the results of the study there is a significant difference in quality of life in carbohydrate metabolism, NT-proBNP, BMI and echocardiographic data. Conclusions: patients with HFwmrLVEF with concomitant type 2 DM compared with patients with HFwmrLVEF without type 2 DM had significantly worse carbohydrate metabolism, significantly higher mean serum NT-proBNP concentration, higher LVMM and iLVMM in transthoracic E quality of life according to the results of the EQ-5D-5L questionnaire in the absence of a significant difference in age and LVEF between groups. In addition, there was a stronger correlation between NT-proBNP and iLVMM in patients without type 2 DM and no correlation between NT-proBNP and LVMM in patients with concomitant type 2 DM, which may be due to certain influence of type 2 DM on the process of pro-BNP conversion