The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Japanese Dental Science Review Pub Date : 2022-11-01 DOI:10.1016/j.jdsr.2022.02.003

Nima Farshidfar DDS , Dana Jafarpour DDS , Parsa Firoozi DDS , Sarina Sahmeddini DDS , Shahram Hamedani DDS, MSc , Raphael Freitas de Souza DDS, MSc, PhD , Lobat Tayebi PhD

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引用次数: 21

Abstract

Background

Ongoing research in the dental field has begun to focus on the use of injectable platelet-rich fibrin (I-PRF) as a regenerative tool with the potential to prompt tissue regeneration. In this regard, this systematic scoping review aimed to collect, map, and appraise the in vitro and in vivo studies regarding the role of I-PRF in or soft and hard tissue regeneration in relation to oral and maxillofacial structures.

Methods

A systematic electronic search of Medline, Scopus, Web of Science, and Embase databases was performed from 2000 to December 2021 using a combination of keywords. All in vitro and in vivo studies, written in English and concerning the potential role of I-PRF in regenerative dentistry were considered.

Results

In total, 18 in vitro studies, 5 animal studies, 6 case reports, and 31 clinical studies have evaluated the effect of I-PRF on oral and maxillofacial soft and hard tissue regeneration. The investigated studies verified the anti-inflammatory, anti-microbial efficacy and the positive effects of I-PRF application for wound, periodontal, bone, cartilage, and pulp regeneration, as well as acceleration in tooth movement during orthodontic treatment.

Conclusions

Current literature approves the feasibility of I-PRF application as a promising regenerative adjunct to dental procedures.

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可注射富血小板纤维蛋白在再生牙科中的应用:体外和体内研究的系统综述

背景牙科领域正在进行的研究已经开始关注可注射的富血小板纤维蛋白(I-PRF)作为一种具有促进组织再生潜力的再生工具。在这方面，本系统的范围综述旨在收集、绘制和评估关于I-PRF在口腔和颌面结构的软硬组织再生中的作用的体外和体内研究。方法从2000年至2021年12月对Medline、Scopus、Web of Science和Embase数据库进行系统的电子检索。所有关于I-PRF在再生牙科中的潜在作用的体外和体内研究均以英文撰写。结果共有18项体外实验、5项动物实验、6例病例报告和31项临床研究评价了I-PRF对口腔颌面部软硬组织再生的影响。调查研究证实了I-PRF在正畸治疗过程中对伤口、牙周、骨、软骨和牙髓再生的抗炎、抗菌作用和积极作用，以及加速牙齿移动的作用。结论目前的文献证实了I-PRF作为一种有前景的牙科再生辅助材料的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.