Community assessment of incidence of quantitative microalbuminuria at the time of first diagnosis of type 2 diabetes mellitus – kumbakonam urban–rural epidemiological study – kures 9

Abstract

Background: Diabetic nephropathy (DN) is a condition defined by persistent albuminuria and progressive loss of kidney function, with the term implying the occurrence of a typical described pattern of glomerular disorder. The early marker of the disease is detecting microalbuminuria in the urine. Methods: The patients who consented for the sampling was considered when they were diagnosed with diabetes mellitus (DM) for the first time. The first hundred adult patients who consented to participate were included. Established methods were used to estimate quantitative microalbumin in the urine from the first sample of the morning. All the positive reports were counter-checked. The initiation of drugs was left to the physician's choice. Any other events were recorded. On arrival, random blood sugar and blood pressures were recorded. Descriptive analyses and Pearson correlation analyses were used. Results: A total of 101 patients were analyzed. There were 58 males and 43 females. The microalbuminuria was positive in 44.6% of newly diagnosed cases. There was no relationship between the random sugar values, age, or sex with the incidence of microalbuminuria. The mean ages of both the positive and negative cases were similar. Conclusion: There was a high incidence of microalbuminuria in our study among newly diagnosed DM. With such a high incidence of early renal damage on diagnosis, we suggest that the initial management should switch from other drugs to inhibitors of the sodium-glucose cotransporter 2 (SGLT2). We theorize that the high incidence may be due to a delayed diagnosis of diabetes in our area and a poor control of the disease. With such a high incidence of early renal damage on diagnosis, we suggest that the initial management should switch from other drugs to inhibitors of the SGLT2. This is the first such study on the incidence of early nephropathy on first diagnosis of DM.